Detalhe da pesquisa
1.
Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/ß-catenin signaling pathway inhibitor.
Bioorg Chem
; 145: 107178, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359708
2.
Repurposing of conformationally-restricted cyclopentane-based AKT-inhibitors leads to discovery of potential and more selective antileishmanial agents than miltefosine.
Bioorg Chem
; 141: 106890, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783099
3.
Mepirapim, a novel synthetic cannabinoid, induces Parkinson's disease-related behaviors by causing maladaptation of the dopamine system in the brain.
Arch Toxicol
; 97(2): 581-591, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355181
4.
Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase.
J Enzyme Inhib Med Chem
; 38(1): 2217695, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37246947
5.
Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani.
J Enzyme Inhib Med Chem
; 38(1): 2229071, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37381756
6.
Positional scanning of natural product hispidol's ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases.
J Enzyme Inhib Med Chem
; 37(1): 768-780, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35196956
7.
The dopaminergic alterations induced by 4-F-PCP and 4-Keto-PCP may enhance their drug-induced rewarding and reinforcing effects: Implications for abuse.
Addict Biol
; 26(4): e12981, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33135332
8.
Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani.
J Enzyme Inhib Med Chem
; 36(1): 1922-1930, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425714
9.
Fluorinated CRA13 analogues: Synthesis, in vitro evaluation, radiosynthesis, in silico and in vivo PET study.
Bioorg Chem
; 99: 103834, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32334193
10.
25C-NBF, a new psychoactive substance, has addictive and neurotoxic potential in rodents.
Arch Toxicol
; 94(7): 2505-2516, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32296860
11.
25B-NBOMe, a novel N-2-methoxybenzyl-phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: Evidence of abuse potential.
Addict Biol
; 25(6): e12850, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749223
12.
The potent psychomotor, rewarding and reinforcing properties of 3-fluoromethamphetamine in rodents.
Addict Biol
; 25(6): e12846, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31797481
13.
The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4'-F-PCP) in Rodents.
Int J Mol Sci
; 21(13)2020 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32610694
14.
QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic Cannabinoids.
Molecules
; 25(24)2020 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33371501
15.
Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot ß-Arylation of Chromanones with Arylboronic Acids.
J Org Chem
; 84(16): 10012-10023, 2019 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31322349
16.
Antiproliferative 3-deoxysphingomyelin analogs: Design, synthesis, biological evaluation and molecular docking of pyrrolidine-based 3-deoxysphingomyelin analogs as anticancer agents.
Bioorg Chem
; 84: 444-455, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30576908
17.
Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids.
Bioorg Chem
; 84: 51-62, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30481646
18.
Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB2R affinity.
Bioorg Med Chem
; 26(18): 5069-5078, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217464
19.
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.
Bioorg Med Chem
; 26(1): 232-244, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29198609
20.
Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library.
Bioorg Chem
; 75: 393-405, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29102722