Detalhe da pesquisa
1.
Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii.
PLoS Biol
; 16(9): e2005642, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30208022
2.
Characterization of the ATP4 ion pump in Toxoplasma gondii.
J Biol Chem
; 294(14): 5720-5734, 2019 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30723156
3.
Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes.
J Biol Chem
; 293(34): 13327-13337, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29986883
4.
The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens.
PLoS Pathog
; 13(2): e1006180, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28178359
5.
A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.
J Biol Chem
; 292(18): 7662-7674, 2017 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28258212
6.
Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555632
7.
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.
PLoS Pathog
; 12(7): e1005725, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27441371
8.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Proc Natl Acad Sci U S A
; 111(50): E5455-62, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453091
9.
Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.
J Infect Dis
; 213(5): 800-10, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503982
10.
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Mol Microbiol
; 97(2): 381-95, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25898991
11.
Diverse chemotypes disrupt ion homeostasis in the Malaria parasite.
Mol Microbiol
; 94(2): 327-39, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25145582
12.
Membrane transport in the malaria parasite and its host erythrocyte.
Biochem J
; 457(1): 1-18, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24325549
13.
A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets.
ACS Infect Dis
; 10(4): 1185-1200, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38499199
14.
Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides.
Int J Parasitol Drugs Drug Resist
; 25: 100536, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38663046
15.
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
J Med Chem
; 66(5): 3540-3565, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812492
16.
Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.
Eur J Med Chem
; 236: 114324, 2022 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35390711
17.
A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Nat Commun
; 13(1): 5746, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36180431
18.
An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum.
J Biol Chem
; 285(24): 18615-26, 2010 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20332090
19.
Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.
Mol Microbiol
; 77(4): 1039-51, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598081
20.
Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.
Antimicrob Agents Chemother
; 55(5): 2310-8, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21343459