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1.
BMC Anesthesiol ; 20(1): 76, 2020 04 04.
Artigo em Inglês | MEDLINE | ID: mdl-32247309

RESUMO

BACKGROUND: Arm conicity is associated with non-invasive blood pressure (NIBP) measurement error and may be avoided by using finger cuffs. Predicting arm conicity may help decisions regarding NIBP measurement techniques. METHODS: We obtained upper limb measurements of adults presenting to the Pre-Anesthetic Clinic to determine: the suitability of arm and finger cuff sizes; the best anthropometric predictor of arm conicity based on the right arm slant angle; the incidence of a right arm slant angle < 83 degrees. Right mid-arm circumference (MAC) was compared to recommended cuff sizes and finger circumference compared to available cuffs. Slant angle was calculated from the measurements obtained. Linear regression was used to determine the better predictor of right arm slant angle. Correlation coefficients were calculated and R2 values compared. RESULTS: Four hundred fifty-four patients participated and 453 had cone-shaped arms. One participant (0.2, 95% CI 0.0-1.2) had a MAC outside the recommended cuff range. Twenty-five participants (5.5, 95% CI 3.6-8.0) had a middle finger circumference greater than the largest ClearSight™ cuff. Body mass index (BMI), weight and right MAC all had low to moderate correlation with right arm slant angle (r = - 0.49, - 0.39, - 0.48, all p < 0.001) and regression revealed R2 values of 0.24, 0.15 and 0.23. Six participants (1.3, 95% CI 0.5-2.9) had a slant angle < 83 degrees. CONCLUSION: Current NIBP equipment caters for most patients, based on the traditional measure of MAC. The utility of finger cuffs is limited by cuff size. BMI and right MAC showed the most promise in predicting arm conicity.


Assuntos
Braço/anatomia & histologia , Determinação da Pressão Arterial/métodos , Pressão Sanguínea/fisiologia , Dedos/anatomia & histologia , Adulto , Idoso , Determinação da Pressão Arterial/instrumentação , Índice de Massa Corporal , Peso Corporal , Procedimentos Cirúrgicos Eletivos , Desenho de Equipamento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
2.
J Cutan Pathol ; 46(8): 599-602, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30989672

RESUMO

Capicua transcriptional repressor (CIC)-rearranged sarcomas are part of the group of Ewing-like sarcomas or atypical Ewing sarcomas which, thanks to the progress in molecular diagnosis, are being defined by particular genetic abnormalities separating this group into distinct entities with their own particular histological and immunohistochemical features, as well as different survival outcomes. We report the case of a healthy 28-year-old female presenting with a tender lesion on her forearm which after ultrasound examination was clinically favored to represent an infected sebaceous cyst. Hematoxylin-eosin staining showed a lobulated neoplasm within the subcutis composed of poorly differentiated epithelioid to round cells with a small amount of amphophilic cytoplasm. Frequent mitotic figures and tumor necrosis were present. Immunohistochemical studies showed patchy focal CD99 membranous positivity, negative WT1 and TLE1 staining and diffuse nuclear positivity for ETV4 (performed at outside laboratory). FISH analysis showed significant CIC rearrangement enabling a final diagnosis of an undifferentiated small round cell sarcoma harboring the t(4;19)(q35;q13.1) and CIC-DUX4 fusion. This case shows the importance of awareness of this entity as, unlike Ewing sarcoma, these lesions present in the soft tissues rather than bone and may, as in this case, arise in the superficial soft tissues and be submitted to a dermatopathology practice.


Assuntos
Cisto Epidérmico , Antebraço , Rearranjo Gênico , Proteínas de Homeodomínio , Proteínas de Fusão Oncogênica , Proteínas Repressoras , Sarcoma de Células Pequenas , Neoplasias Cutâneas , Adulto , Cromossomos Humanos Par 19/genética , Cromossomos Humanos Par 19/metabolismo , Cromossomos Humanos Par 4/genética , Cromossomos Humanos Par 4/metabolismo , Proteínas Correpressoras/genética , Proteínas Correpressoras/metabolismo , Cisto Epidérmico/genética , Cisto Epidérmico/metabolismo , Cisto Epidérmico/patologia , Feminino , Proteínas de Homeodomínio/genética , Proteínas de Homeodomínio/metabolismo , Humanos , Hibridização in Situ Fluorescente , Proteínas de Fusão Oncogênica/genética , Proteínas de Fusão Oncogênica/metabolismo , Proteínas Proto-Oncogênicas c-ets/genética , Proteínas Proto-Oncogênicas c-ets/metabolismo , Proteínas Repressoras/genética , Proteínas Repressoras/metabolismo , Sarcoma de Células Pequenas/genética , Sarcoma de Células Pequenas/metabolismo , Sarcoma de Células Pequenas/patologia , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia , Translocação Genética , Proteínas WT1/genética , Proteínas WT1/metabolismo
3.
J Surg Case Rep ; 2024(7): rjae437, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38966686

RESUMO

Atraumatic splenic rupture is a complex surgical pathology owing to its rarity, non-specificity of symptoms and gravity of possible outcomes. This case outlines the investigation and management of a patient with atraumatic splenic rupture secondary to undiagnosed hairy cell leukaemia. While the patient was initially managed conservatively, they went on to have a splenectomy owing to ongoing transfusion requirements. A review of the literature has also been performed and presented to highlight the potential causes of atraumatic splenic rupture and the various options for confirming diagnosis and definitive management.

4.
Obesity (Silver Spring) ; 28(4): 718-723, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32096341

RESUMO

OBJECTIVE: In patients with obesity, it was determined what proportion had an arm slant angle (SA) < 83° and which measure best predicted arm conicity. Patient experience with noninvasive blood pressure measurement was evaluated. METHODS: Arm SA was calculated from arm measurements. Linear regression determined whether BMI, weight, or right midarm circumference (MAC) best predicted conicity. Patient experiences were evaluated by survey and conventional content analysis of free-text comments. RESULTS: One hundred participants had a median (interquartile range; range) BMI of 44.1 (39.1-53.1; 31.1-80.8). Thirty-three (33%) had a right arm SA < 83°. Seven (7%) had a right MAC outside the recommended range. BMI, weight, and the right MAC showed low correlation with and explained little of the variation (with age and sex adjustment) in right arm SA (r = -0.29, -0.27, -0.31; P = 0.003, 0.007, 0.002; R2 = 0.09, 0.08, 0.10). Forty-two (42%) reported noninvasive blood pressure measurement caused severe pain, and 30 (30%) reported skin damage. Themes identified in free-text responses were "problems with equipment," "feelings and experiences," and "concerns about accuracy." CONCLUSIONS: Current equipment is inadequate for patients with obesity based on MAC and conicity. Pain and skin damage contributed to negative experiences of these patients.


Assuntos
Braço/anatomia & histologia , Determinação da Pressão Arterial/instrumentação , Pressão Sanguínea/fisiologia , Obesidade/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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