Detalhe da pesquisa
1.
A clinical population pharmacokinetic/pharmacodynamic model for BIIB059, a monoclonal antibody for the treatment of systemic and cutaneous lupus erythematosus.
J Pharmacokinet Pharmacodyn
; 47(3): 255-266, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32335844
2.
A pre-clinical quantitative model predicts the pharmacokinetics/pharmacodynamics of an anti-BDCA2 monoclonal antibody in humans.
J Pharmacokinet Pharmacodyn
; 45(6): 817-827, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30377889
3.
Preemptive Panel-Based Pharmacogenetic Testing: The Time is Now.
Pharm Res
; 34(8): 1551-1555, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28466392
4.
Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.
Ther Drug Monit
; 37(4): 428-36, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26186657
5.
Clinical implementation of genetic testing in medicine: a US regulatory science perspective.
Br J Clin Pharmacol
; 77(4): 606-11, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24286486
6.
Exploring the impact of CYP2D6 and UGT2B7 gene-drug interactions, and CYP-mediated DDI on oxycodone and oxymorphone pharmacokinetics using physiologically-based pharmacokinetic modeling and simulation.
Eur J Pharm Sci
; 194: 106689, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38171419
7.
Medical applications of microarray technologies: a regulatory science perspective.
Nat Genet
; 32 Suppl: 474-9, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12454641
8.
Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.
Biopharm Drug Dispos
; 33(2): 99-110, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22270945
9.
Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin.
Cells
; 12(1)2022 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36611850
10.
Advancing drug safety science by integrating molecular knowledge with post-marketing adverse event reports.
CPT Pharmacometrics Syst Pharmacol
; 11(5): 540-555, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35143713
11.
Application of a patient-centered reverse translational systems-based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors.
Clin Transl Sci
; 15(6): 1430-1438, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35191192
12.
Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations.
J Clin Pharmacol
; 62(1): 66-75, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34328221
13.
A case study of a patient-centered reverse translational systems-based approach to understand adverse event profiles in drug development.
Clin Transl Sci
; 15(4): 1003-1013, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35014203
14.
Dosing Regimen Prediction and Confirmation With Rivaroxaban for Thromboprophylaxis in Children After the Fontan Procedure: Insights From the Phase III UNIVERSE Study.
J Clin Pharmacol
; 62(2): 220-231, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34524700
15.
Perspective on model-informed drug development.
CPT Pharmacometrics Syst Pharmacol
; 10(10): 1127-1129, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34404115
16.
Physiologically-based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate.
CPT Pharmacometrics Syst Pharmacol
; 10(3): 199-210, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33449439
17.
Quantitative Systems Pharmacology Model-Based Predictions of Clinical Endpoints to Optimize Warfarin and Rivaroxaban Anti-Thrombosis Therapy.
Front Pharmacol
; 11: 1041, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32765265
18.
Semi-mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities.
Br J Pharmacol
; 177(15): 3568-3590, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32335903
19.
A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity.
J Clin Pharmacol
; 49(2): 138-46, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179293
20.
Is Bioequivalence Established Based on the Reference-Scaled Average Bioequivalence Approach Relevant to Chronic Administration of Phenytoin? Perspectives Based on Population Pharmacokinetic Modeling and Simulations.
J Clin Pharmacol
; 59(8): 1061-1069, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30716169