Detalhe da pesquisa
1.
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
Cell
; 159(7): 1549-62, 2014 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25525874
2.
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.
PLoS Biol
; 22(5): e3002617, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38696533
3.
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Nat Rev Mol Cell Biol
; 15(1): 49-63, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24355989
4.
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Blood
; 141(6): 634-644, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36219880
5.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol Cell
; 68(4): 659-672.e9, 2017 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29149594
6.
Improved drug target deconvolution with PISA-DIA using an extended, overlapping temperature gradient.
Proteomics
; : e2300644, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38766901
7.
BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage.
EMBO J
; 39(24): e105561, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33236795
8.
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
EMBO J
; 39(18): e106275, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32845033
9.
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Biochem J
; 480(9): 665-684, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37115711
10.
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Nat Chem Biol
; 15(11): 1057-1066, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591564
11.
Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use.
Blood
; 132(15): 1573-1583, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30139826
12.
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.
Blood
; 128(14): 1834-1844, 2016 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27465916
13.
Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.
Cell Microbiol
; 19(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27781359
14.
Strategies, Setbacks, and Successes in the Synthesis of (-)-Spiroleucettadine.
J Org Chem
; 83(17): 10120-10133, 2018 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30003773
15.
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Proc Natl Acad Sci U S A
; 111(42): 15072-7, 2014 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288762
16.
Total Synthesis of (-)-Spiroleucettadine.
Angew Chem Int Ed Engl
; 56(46): 14663-14666, 2017 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28960638
17.
Structure-guided design of a selective BCL-X(L) inhibitor.
Nat Chem Biol
; 9(6): 390-7, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23603658
18.
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Biochem J
; 457(3): 369-77, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24219132
19.
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
J Med Chem
; 66(4): 2361-2385, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36781172
20.
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Cell Death Differ
; 30(4): 1033-1046, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36739334