Detalhe da pesquisa
1.
Necrostatin-1 Analog DIMO Exerts Cardioprotective Effect against Ischemia Reperfusion Injury by Suppressing Necroptosis via Autophagic Pathway in Rats.
Pharmacology
; 106(3-4): 189-201, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33621976
2.
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat Chem Biol
; 13(4): 389-395, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28135237
3.
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
Bioorg Med Chem Lett
; 27(7): 1576-1583, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254486
4.
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.
Bioorg Med Chem
; 25(1): 166-174, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28340987
5.
Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors.
Bioorg Med Chem
; 23(13): 3221-7, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26003342
6.
Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat Chem Biol
; 13(8): 922, 2017 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853738
7.
Recent advances in the development of P2Y14R inhibitors: a patent and literature review (2018-present).
Expert Opin Ther Pat
; : 1-15, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38889204
8.
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
J Med Chem
; 67(8): 6456-6494, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574366
9.
Design, synthesis and molecular docking of α,ß-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.
Bioorg Med Chem
; 21(2): 388-94, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23245570
10.
Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity.
Bioorg Med Chem
; 21(19): 6084-91, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23962660
11.
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein.
Bioorg Med Chem
; 20(14): 4194-200, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22739087
12.
Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity.
Bioorg Med Chem
; 20(1): 317-23, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22112541
13.
Synthesis and biological evaluation of novel N, N'-disubstituted urea and thiourea derivatives as potential anti-melanoma agents.
J Enzyme Inhib Med Chem
; 27(5): 708-14, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21985377
14.
LSD1 inhibitors for anticancer therapy: a patent review (2017-present).
Expert Opin Ther Pat
; 32(9): 1027-1042, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35914778
15.
Synthesis of potent and orally efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016.
J Org Chem
; 76(17): 7048-55, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21736359
16.
Discovery of vinylogous carbamates as a novel class of ß-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.
Bioorg Med Chem
; 19(15): 4454-9, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742506
17.
Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase.
J Enzyme Inhib Med Chem
; 26(1): 37-45, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20583855
18.
Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors.
Bioorg Med Chem Lett
; 20(22): 6653-6, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20943391
19.
Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents.
Bioorg Med Chem Lett
; 20(6): 2025-8, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153183
20.
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents.
Bioorg Med Chem
; 18(13): 4606-14, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20627597