Chronic viral hepatitis C micro-elimination program using telemedicine in Guigang city.

Hepatitis C virus (HCV) represents a formidable menace to human health, necessitating urgent attention. The objective of this study was to assess the efficacy and safety of HCV health management in the city of Guigang which consists of five districts, employing a comprehensive multi-modal approach. The study systematically carried out HCV screening in Guigang city which consists of five districts, such as Gangbei District, Gangnan District, Guiping District, Qintang District, and Pingnan District from 1 January 2016 to 30 December 2022. The target population consisted of individuals residing in these aforementioned districts, falling within the age range of 30-75 years. A multidisciplinary HCV management team was established to deliver anti-HCV screening, diagnosis, and direct-acting antiviral (DAA) therapy. The primary outcome of interest was the achievement of sustained virologic response (SVR). A total of 2489 individuals were included as the target population, with 1694 individuals residing in Gangbei District, 202 in Gangnan District, 111 in Qintang District, 167 in Pingnan District, and 315 in Guiping District. Out of these individuals, 2478 were subjected to anti-HCV screening. The screening rates varied across the districts, ranging from a peak of 99.55% in Guigang City to a nadir of 98.41% in Guiping District. Remarkably, within Guigang City, a noteworthy enhancement was observed in the HCV-RNA diagnosis rate from 23.4% prior to program implementation to a remarkable 100% following 7 years of intervention and management. Furthermore, the diagnosis and treatment coordination rate experienced a substantial improvement, rising from 26.8% before program inception to 80%. Importantly, a total of 1180 individuals affected by hepatitis C were successfully cured, equating to a 100% cure rate. Logistic regression analysis revealed a significant association between serological status and factors such as Aging, bilirubin, and glutamic oxalacetic transaminase. The findings from our investigation unveil a pioneering HCV management model, exemplified by the Guigang model, which has contributed crucially to HCV microclearance efforts and serves as an invaluable reference for future initiatives.

MB38(M=Be and Zn): A Quasi-Planar Structure Rather Than A Core-Shell Octahedral Borospherene Structure.

In a recent paper (ChemPhysChem, 2023, 24, e202200947), based on the results computed using DFT method, the perfect core-shell octahedral configuration Be@B38 and Zn@B38 was reported to be the global minima of the MB38(M=Be and Zn) clusters. However, this paper presents the lower energy structures of MB38(M=Be and Zn) clusters as a quasi-planar configuration, the Be atom is found to reside on the convex surface of the quasi-planar B38 isomer, while the Zn atom tends to be attached to the top three B atoms of the quasi-planar B38 isomer. Our results show that quasi-planar MB38(M=Be and Zn) at DFT method have lower energy than core-shell octahedral configuration M@B38(M=Be and Zn). Natural atomic charges, valence electron density, electron localization function (ELF) analyses identify the MB38(M=Be and Zn) to be charge transfer complexes (Be2+B382-and Be1+B381-) and suggest primarily the electrostatic interactions between doped atom and B38 fragment. The photoelectron spectra of the corresponding anionic structures were simulated, providing theoretical basis for future structural identification.

Metal-Organic Framework Supported Low-Nuclearity Cluster Catalysts for Highly Selective Carbon Dioxide Electroreduction to Ethanol.

It is still a great challenge to achieve high selectivity of ethanol in CO2 electroreduction reactions (CO2RR) because of the similar reduction potentials and lower energy barrier of possible other C2+ products. Here, we report a MOF-based supported low-nuclearity cluster catalysts (LNCCs), synthesized by electrochemical reduction of three-dimensional (3D) microporous Cu-based MOF, that achieves a single-product Faradaic efficiency (FE) of 82.5% at -1.0 V (versus the reversible hydrogen electrode) corresponding to the effective current density is 8.66 mA cm-2. By investigating the relationship between the species of reduction products and the types of catalytic sites, it is confirmed that the multi-site synergism of Cu LNCCs can increase the C-C coupling effect, and thus achieve high FE of CO2-to-ethanol. In addition, density functional theory (DFT) calculation and operando attenuated total reflectance surface-enhanced infrared absorption spectroscopy further confirmed the reaction path and mechanism of CO2-to-EtOH.

Application of oncolytic virus in tumor therapy.

Oncolytic viruses (OVs) can selectively kill tumor cells without affecting normal cells, as well as activate the innate and adaptive immune systems in patients. Thus, they have been considered as a promising measure for safe and effective cancer treatment. Recently, a few genetically engineered OVs have been developed to further improve the effect of tumor elimination by expressing specific immune regulatory factors and thus enhance the body's antitumor immunity. In addition, the combined therapies of OVs and other immunotherapies have been applied in clinical. Although there are many studies on this hot topic, a comprehensive review is missing on illustrating the mechanisms of tumor clearance by OVs and how to modify engineered OVs to further enhance their antitumor effects. In this study, we provided a review on the mechanisms of immune regulatory factors in OVs. In addition, we reviewed the combined therapies of OVs with other therapies including radiotherapy and CAR-T or TCR-T cell therapy. The review is useful in further generalize the usage of OV in cancer treatment.

Fiber liquid-pressure sensor with high sensitivity and a wide measurement range using photopolymer.

This paper presents a novel fiber liquid-pressure sensor that uses photopolymer glue to generate Fabry-Perot (F-P) interference, resulting in high sensitivity and a wide measurement range. The sensor comprises a single-mode fiber and photopolymer glue; the latter adheres to the fiber's end face and is decomposed by a 405-nm laser to create an air channel with a diameter of 5.9 µm and a length of 50 µm. When the air channel is placed underwater, a 17.5-µm air cavity forms between the fiber core and the air-liquid boundary due to the pressure balance, creating an F-P interferometer. Based on experimental results, the sensor has an average pressure sensitivity of 5.68 nm/kPa over 0.49-2.94 kPa. The sensitivity can be maintained at this level across different pressure measurement ranges (up to about 500 kPa) by using a 980-nm laser's radiation pressure to reset the air-liquid boundary. Besides its high sensitivity and wide measurement range, the sensor's straightforward structure, durability, affordability, compactness, and simple construction make it an appealing choice for liquid pressure measurement applications in various fields.

Luminescence Enhancement of K2LiAlF6:Mn4+ Phosphors by Zn2+-Mediated Charge Compensation for Fast-Response Backlighting Applications.

Wide-spectrum displays require narrow-band red phosphors activated by Mn4+, but most of them, such as K2SiF6:Mn4+, have long fluorescence decay lifetimes (>7 ms) that hinder their use in fast-response backlights. Interestingly, K2LiAlF6:0.05Mn4+ has a shorter fluorescence lifetime (3.43 ms), but its disadvantage is that its luminescence intensity is relatively weak. So, in this study, the luminescence intensity of K2LiAlF6:0.05Mn4+ is improved by doping with Zn2+. The experimental results show that enhancement of the luminous intensity is as high as 39%, the fluorescence lifetime is only increased by 13% (3.89 ms), and it is still less than 4 ms. Through experiments and differential charge density calculations, it has been revealed that the luminescence intensity improvement is due to an increased crystalline quality during the synthesis process. Specifically, the co-doping of Zn2+ reduces the formation of impurity ions Mn2+ and Mn3+ and the generation of K+ vacancies caused by nonequivalent doping. We demonstrate the advantage of this phosphor over K2SiF6:Mn4+ in terms of response speed by using a camera. It emits only weak red light after the blue chip stops working for 5 ms, indicating its potential application in next-generation fast-response displays.

Structural Evolution and Electronic Properties of Selenium-Doped Boron Clusters SeBn0/- (n = 3-16).

A theoretical research of structural evolution, electronic properties, and photoelectron spectra of selenium-doped boron clusters SeBn0/- (n = 3-16) is performed using particle swarm optimization (CALYPSO) software in combination with density functional theory calculations. The lowest energy structures of SeBn0/- (n = 3-16) clusters tend to form quasi-planar or planar structures. Some selenium-doped boron clusters keep a skeleton of the corresponding pure boron clusters; however, the addition of a Se atom modified and improved some of the pure boron cluster structures. In particular, the Se atoms of SeB7-, SeB8-, SeB10-, and SeB12- are connected to the pure quasi-planar B7-, B8-, B10-, and B12- clusters, which leads to planar SeB7-, SeB8-, SeB10-, and SeB12-, respectively. Interestingly, the lowest energy structure of SeB9- is a three-dimensional mushroom-shaped structure, and the SeB9- cluster displays the largest HOMO-LUMO gap of 5.08 eV, which shows the superior chemical stability. Adaptive natural density partitioning (AdNDP) bonding analysis reveals that SeB8 is doubly aromatic, with 6 delocalized π electrons and 6 delocalized σ electrons, whereas SeB9- is doubly antiaromatic, with 4 delocalized π electrons and 12 delocalized σ electrons. Similarly, quasi-planar SeB12 is doubly aromatic, with 6 delocalized π electrons and 14 delocalized σ electrons. The electron localization function (ELF) analysis shows that SeBn0/- (n = 3-16) clusters have different local electron delocalization and whole electron delocalization effects. The simulated photoelectron spectra of SeBn- (n = 3-16) have different characteristic bands that can identify and confirm SeBn- (n = 3-16) combined with future experimental photoelectron spectra. Our research enriches the geometrical structures of small doped boron clusters and can offer insight for boron-based nanomaterials.

Structure Types and Magnetic Behavior of Cobalt Nanoclusters.

Caprylic hydrazide ligands are ideal ligands for the synthesis of novel polynuclear metal complexes, because they contain many N,O coordination atoms with a strong coordination ability, abundant hydrogen-bond donors, acceptors, and large conjugation systems. Here, we successfully obtained one dodecanuclear cobalt nanocluster [CoII8CoIII4(L1)4(Py)12(CH3OH)4(CH3COO)4]·(CH3OH)13 (1) and one octadecanuclear cobalt nanocluster [CoII18(L2)6(Py)48]·(DMF)5·(CH3OH)8 (2) by using H6L1 and H6L2 ligands, respectively (Py = pyridine; DMF = dimethylformamide). The cyclic cobalt nanocluster 1 can be regarded as two pentanuclear cobalt units (Co5(N-N)4) connected by two cobalt ions, and it is a mixed-valent Co nanocluster. Every H6L1 ligand contains 10 coordination atoms, each of which coordinates with the Co ions. And every two H6L1 ligands form a structure similar to a handshake. The abnormal cylindrical cobalt nanocluster 2 can be regarded six trinuclear cobalt units Co3(N-N)2 connected by one L26- ligand, and every L26- ligand splits the structure on both sides, with a twisted cyclohexane in the middle. AC magnetic susceptibilities show that nanocluster 1 exhibits no frequency-dependent behavior, but nanocluster 2 shows an obviously single-molecule magnetic behavior, and the relaxation process of the energy barrier is 20.4 K.

Culture and purification of SD rat corpus cavernosum endothelial cells by enzymatic digestion combined with mechanical extrusion and fixed-point digestion.

To explore a new method of in vitro culture and purification of rat corpus cavernosum endothelial cells (CCECs). Male Sprague-Dawley rats' penile tissue were digested with elastase or collagenase combined with mechanical extrusion to isolate and culture the CCECs. The fixed-point digestion method was used to purify the primary cells. High-purity CCECs were successfully isolated. Following the digestion of the primary CCECs by elastase or collagenase coupled with mechanical extrusion, the cells were paving stone- and cobblestone-shaped over 10 days. The cell purity yielded in the second generation (P2) CCECs after using the fixed-point digestion method was significantly high. Compared with primary CCECs extracted by elastase digestion combined with the mechanical extrusion method, CCECs cultured by collagenase digestion yielded higher purity and a more stable morphology after fixed-point digestion and purification. Immunofluorescence staining of the third generation CCECs and the expression results of endothelial cell-associated marker antibodies CD31 and VWF were positive, and flow cytometry showed the purity of CCECs was 96.9%. Enzymatic digestion combined with mechanical extrusion and fixed-point digestion is a simple, economical method for in vitro culture and purification of CCECs, which is conducive to studying the pathophysiological mechanisms of endothelial dysfunction and erectile dysfunction.

A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy.

Prostate cancer (PCa) is the second most common cancer in men, causing more than 300,000 deaths every year worldwide. Due to their superior cell-killing ability and the relative simplicity of their preparation, immunotoxin molecules have great potential in the clinical treatment of cancer, and several such molecules have been approved for clinical application. In this study, we adopted a relatively simple strategy based on a single-domain antibody (sdAb) and an improved Pseudomonas exotoxin A (PE) toxin (PE24X7) to prepare a safer immunotoxin against prostate-specific membrane antigen (PSMA) for PCa treatment. The designed anti-PSMA immunotoxin, JVM-PE24X7, was conveniently prepared in its soluble form in an Escherichia coli (E. coli) system, avoiding the complex renaturation process needed for immunotoxin preparation by the conventional strategy. The product was very stable and showed a very strong ability to bind the PSMA receptor. Cytotoxicity assays showed that this molecule at a very low concentration could kill PSMA-positive PCa cells, with an EC50 value (concentration at which the cell viability decreased by 50%) of 15.3 pM against PSMA-positive LNCaP cells. Moreover, this molecule showed very good killing selectivity between PSMA-positive and PSMA-negative cells, with a selection ratio of more than 300-fold. Animal studies showed that this molecule at a very low dosage (5 × 0.5 mg/kg once every three days) completely inhibited the growth of PCa tumors, and the maximum tolerable dose (MTD) was more than 15 mg/kg, indicating its very potent tumor-treatment ability and a wide therapeutic window. Use of the new PE toxin, PE24X7, as the effector moiety significantly reduced off-target toxicity and improved the therapeutic window of the immunotoxin. The above results demonstrate that the designed anti-PSMA immunotoxin, JVM-PE24X7, has good application value for the treatment of PCa.

In-Situ Synthesis and High-Efficiency Photocatalytic Performance of Cu(I)/Cu(II) Inorganic Coordination Polymer Quantum Sheets.

Two-dimensional (2D) materials ultrathin quantum sheets have the advantage of elevating the catalysis performance and prominent edge effects, but most of them belong to element single valence materials. In this paper, the ultrathin Cu(I)/Cu(II) inorganic coordination polymer quantum sheet (ICPQS) {[CuII(H2O)4][CuI4(CN)6]} n is synthesized by controlling the appropriate molar ratio of raw material, reaction time, and temperature. Transmission electron microscopy (TEM) and atomic force microscope (AFM) analysis show that this ICPQS has a thickness of ∼0.2 nm. Due to the fact that about 58.16% of the Cu(I)/Cu(II) is occupied in molecular structure and most of the metal active sites are fully utilized, this ICPQS can accelerate the photocatalytic degradation of methylene blue (MB) (K = 2.5 mg·L-1·min-1 at pH 3) and organic compounds in coking wastewater and biotreated coking wastewater. Basing on mixed valences, the ICPQS can use visible light to promote energy transfer and increase quantum efficiency, paving the way for developing the next-generation monolayer 2D mixed valence photocatalysts.

Research on AIDS patients' survival time after highly active antiretroviral therapy, treatment effect and treatment modes.

To fully define clinical efficacy of highly active antiretroviral therapy for AIDS, analyze patients' survival time and treatment mode after receiving treatment, and provide scientific theory to guide improvement of antiviral therapy, this paper selected 3100 cases of patients diagnosed with AIDS during April 2006 and April 2014 as object of this study. All patients were treated with highly active antiretroviral therapy. The main analysis contents of this study include CD4 + T lymphocyte count, viral load changes, incidence of opportunistic infections, specific cause of death and the like. The results show that patients' CD4 + T lymphocyte levels are significantly increased 3, 18, and 24 months after treatment, difference between the situation after and before receiving treatment, P < 0.05, with statistically significant difference. Analyzed from effective inhibition of virus, effective inhibition rate is 72.58.0% (2250/3100). Main causes of death in patients is usually respiratory failure. It thus can be concluded that highly active antiretroviral therapy for AIDS is with good clinical effect, which can effectively improve survival time of patients. So it enjoys application value of being widely used in clinical treatment of AIDS.

Size effects and electronic properties of zinc-doped boron clusters Zn B n (n = 1-15).

CONTEXT: To gain a deeper understanding of zinc-doped boron clusters, theoretical calculations were performed to investigate the size effects and electronic properties of zinc-doped boron clusters. The study of the electronic properties, spectral characteristics, and geometric structures of Zn B n (n = 1-15) is of great significance in the fields of semiconductor materials science, material detection, and improving catalytic efficiency. The results indicate that Zn B n (n = 1-15) clusters predominantly exhibit planar or quasi-planar structures, with the Zn atom positioned in the outer regions of the B n framework. The second stable structure of Zn B 3 is a three-dimensional configuration, indicating that the structures of zinc-doped boron clusters begin to convert from the planar or quasi-planar structures to the 3D configurations. The second low-energy structure of Zn B 15 is a novel configuration. Relative stability analyses show that the Zn B 12 has better chemical stability than other clusters with a HOMO-LUMO gap of 2.79 eV. Electric charge analysis shows that part electrons on zinc atoms are transferred to boron atoms, and electrons prefer to cluster near the B n framework. According to the electron localization function, it gets harder to localize electrons as the equivalent face value drops, and it's challenging to see covalent bond formation between zinc and boron atoms. The spectrograms of Zn B n (n = 1-15) exhibit distinct properties and notable spectral features, which can be used as a theoretical basis for the identification and confirmation of boron clusters doped with single-atom transition metals. METHODS: The calculations were performed using the ABCluster global search technique combined with density functional theory (DFT) methods. The selected low-energy structures were subjected to geometric optimization and frequency calculations at the PBE0/6-311 + G(d) level to ensure structural stability and eliminate any imaginary frequencies. To acquire more precise relative energies, we performed single-point energies calculations for the low-lying isomers of Zn B n (n = 1-15) at the CCSD(T)/6-311 + G(d)//PBE0/6-311 + G(d) level of theory. All calculations were performed using Gaussian 09 software. To facilitate analysis, we utilized software tools such as Multiwfn, and VMD.

A Bifunctional Three-Dimensional Zn(II) Metal-Organic Framework with Strong Luminescence and Adsorption Cr(VI) Properties.

The mixed ligand 3-amino-1,2,4-triazole (Hatz) and terephthalic acid (H2pta) reacted with Zn(NO3)2·6H2O to synthesize a three-dimensional binuclear Zn(II) metal-organic framework: {[Zn2·(atz)2·(pta)]·3H2O}n (3D-Zn-MOF). This 3D-Zn-MOF has two different types of pores (4.5 × 4.5 Å2, 5.7 × 5.7 Å2). The crystalline 3D-Zn-MOF could be prepared into nanomaterials (3D-N-Zn-MOF) with particles of approximately 100 nm by a cell fragmentation apparatus. Compared with the solid-state luminescence of Hatz and H2pta, it was found that 3D-N-Zn-MOF exhibited strong luminescence performance and significant red-shift phenomenon. Due to the decrease in electronegativity and rigidity of ligands, as well as the effect of ligand metal charge transfer (LMCT), the fluorescence lifetime and quantum yield of 3D-ZN-N-MOF were 2.7241 ns and 3.02%, respectively. The maximum experimental adsorption capacity of 3D-N-Zn-MOF could reach 125.52 mg/g, which was superior to the majority of MOF adsorbents under the optimal adsorption conditions (25 °C, pH = 7, and the adsorbent concentration is 0.2000 g/L). The thermodynamic analysis of adsorption showed that the adsorption of Cr(VI) by 3D-N-Zn-MOF was a spontaneous (△G < 0) and exothermic (△H < 0) process. It could be found that 3D-N-Zn-MOF was a bifunctional material with potential applications by comprehensive analysis of the fluorescence and adsorption Cr(VI) performance.

Structural Evolution and Electronic Properties of Two Sulfur Atom-Doped Boron Clusters.

We present a theoretical study of structural evolution, electronic properties, and photoelectron spectra of two sulfur atom-doped boron clusters S2Bn0/- (n = 2-13), which reveal that the global minima of the S2Bn0/- (n = 2-13) clusters show an evolution from a linear-chain structure to a planar or quasi-planar structure. Some S-doped boron clusters have the skeleton of corresponding pure boron clusters; however, the addition of two sulfur atoms modified and improved some of the pure boron cluster structures. Boron is electron-deficient and boron clusters do not form linear chains. Here, two sulfur atom doping can adjust the pure boron clusters to a linear-chain structure (S2B20/-, S2B30/-, and S2B4-), a quasi-linear-chain structure (S2B6-), single- and double-chain structures (S2B6 and S2B9-), and double-chain structures (S2B5, and S2B9). In particular, the smallest linear-chain boron clusters S2B20/- are shown with an S atom attached to each end of B2. The S2B2 cluster possesses the largest highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap of 5.57 eV and the S2B2- cluster possesses the largest average binding energy Eb of 5.63 eV, which shows the superior chemical stability and relative stability, respectively. Interestingly, two S-atom doping can adjust the quasi-planar pure boron clusters (B7-, B10-, and B120/-) to a perfect planar structure. AdNDP bonding analyses reveal that linear S2B3 and planar SeB11- have π aromaticity and σ antiaromaticity; however, S2B2, planar S2B6, and planar S2B7- clusters have π antiaromaticity and σ aromaticity. Furthermore, AdNDP bonding analyses reveal that planar S2B4, S2B10, and S2B12 clusters are doubly (π and σ) aromatic, whereas S2B5-, S2B8, S2B9-, and S2B13- clusters are doubly (π and σ) antiaromatic. The electron localization function (ELF) analysis shows that S2Bn0/- (n = 2-13) clusters have different electron delocalization characteristics, and the spin density analysis shows that the open-shell clusters have different characteristics of electron spin distribution. The calculated photoelectron spectra indicate that S2Bn- (n = 2-13) have different characteristic peaks that can be compared with future experimental values and provide a theoretical basis for the identification and confirmation of these doped boron clusters. Our work enriches the new database of geometrical structures of doped boron clusters, provides new examples of aromaticity for doped boron clusters, and is promising to offer new ideas for nanomaterials and nanodevices.

PB12+ and P2B12+/0/-: The Novel B12 Cage Doped by Nonmetallic P Atoms.

A new kind of nonmetallic atom-doped boron cluster is described herein theoretically. When a phosphorus atom is added to the B12 motif and loses an electron, a novel B12 cage is obtained, composed of two B3 rings at both ends and one B6 ring in the middle, forming a triangular bifrustum. Interestingly, this B12 cage is formed by three B7 units joined together from three directions at an angle of 120°. When two P atoms are added to the B12 motif, this novel B12 cage is also obtained, and two P atoms are attached to the B3 rings at both ends of the triangular bifrustum, forming a triangular bipyramid (Johnson solid). Amazingly, the global minimums of neutral, monocationic, and monoanionic P2B12+/0/- have the same cage structure with a D3h symmetry; this is the smallest boron cage with the same structure. The P atom has five valence electrons, according to adaptive natural density partitioning bonding analyses of cage PB12+ and P2B12, in addition to one lone pair, the other three electrons of the P atom combine with an electron of each B atom on the B3 ring to form three 2c-2e σ bonds and form three electron sharing bonds with B atoms through covalent interactions, stabilizing the B12 cage. The calculated photoelectron spectra can be compared with future experimental values and provide a theoretical basis for the identification and confirmation of PnB12- (n = 1-2).

High-Efficiency Adsorption of Cr(VI) and Mn(VII) from Wastewater by a Two-Dimensional Copper-Based Metal-Organic Framework.

Cr(VI) and Mn(VII) in industrial wastewater have certain toxicity, and they pose a threat to the environment and human health and safety. Metal-organic frameworks (MOFs) usually have rich adsorption sites and a large specific surface area. They can effectively adsorb Cr(VI) and Mn(VII) from wastewater. In this paper, a two-dimensional copper-based metal-organic framework, {[Cu·(4,4'-bpy)2·(H2O)]·2(NO3)·6(H2O)·(CH3OH)}n (1), is synthesized by hydrothermal synthesis. The structure of 1 is characterized by Fourier transform infrared (IR) spectroscopy, single-crystal X-ray diffraction, element analysis, and X-ray photoelectron spectroscopy (XPS). The results showed that 1 had a two-dimensional network structure, and the specific surface area of the nanostructure was 67.63 m2/g. The nanostructure of 1 could efficiently adsorb Cr(VI) and Mn(VII) from wastewater. The adsorption properties of Cr(VI) and Mn (VII) of 1 showed that the optimal concentration of both adsorbents was 0.2 g/L. It has good adsorption performance in the pH range 4-8. The adsorption performance is the best when pH is 7, which can reach 145 and 83 mg/g, respectively.

Regulation and photocatalytic degradation mechanism of a hydroxyl modified UiO-66 type metal organic framework.

Photocatalytic performance can be effectively improved by modifying the functional groups on the organic ligands of metal organic frameworks (MOFs). Herein, the hydroxyl-modified UiO-66 type MOF: UIO-66-2OH(2,3), was successfully synthesized by the method of ligand exchange by the 2,3-dihydroxyterephthalic acid and UIO-66 as raw materials. The mechanism of photocatalytic degradation of methylene blue (MB) by UIO-66-2OH(2,3) shows that the hydroxyl functional group on the organic ligand regulates its electronegativity and expands its light absorption range. The decomposition of MB is carried out in multiple steps under the oxidation of the hydroxyl radical (˙OH). This research result shows the direction for guiding the synthesis of efficient photocatalysts and clarifying the light absorption of MOFs regulated by hydroxyl functional groups.