Self-powered Pt/a-Ga2O3/ITO vertical Schottky junction solar-blind photodetector with excellent detection performance.

Self-powered solar-blind photodetectors (PDs) are promising for military and civilian applications owing to convenient operation, easy preparation, and weak-light sensitivity. In the present study, the solar-blind deep-ultraviolet (DUV) photodetector based on amorphous Ga2O3 (a-Ga2O3) and with a simple vertical stack structure is proposed by applying the low-cost magnetron sputtering technology. By tuning the thickness of the amorphous Ga2O3 layer, the device exhibits excellent detection performance. Under 3 V reverse bias, the photodetector achieves a high responsivity of 671A/W, a high detectivity of 2.21 × 1015 Jones, and a fast response time of 27/11 ms. More extraordinary, with the help of the built-in electric field at the interface, the device achieves an excellent performance in detection when self-powered, with an ultrahigh responsivity of 3.69 A/W and a fast response time of 2.6/6.6 ms under 254 nm light illumination. These results demonstrate its superior performance to most of the self-powered Schottky junction UV photodetectors reported to date. Finally, the Pt/a-Ga2O3/ITO Schottky junction photodiode detector is verified as a good performer in imaging, indicating its applicability in such fields as artificial intelligence, machine vision, and solar-blind imaging.

Research on a Hybrid Intelligent Method for Natural Gas Energy Metering.

In this paper, a Comprehensive Diagram Method (CDM) for a Multi-Layer Perceptron Neuron Network (MLPNN) is proposed to realize natural gas energy metering using temperature, pressure, and the speed of sound from an ultrasonic flowmeter. Training and testing of the MLPNN model were performed on the basis of 1003 real data points describing the compression factors (Z-factors) and calorific values of the three main components of natural gas in Sichuan province, China. Moreover, 20 days of real tests were conducted to verify the measurements' accuracy and the adaptability of the new intelligent method. Based on the values of the Mean Relative Errors and the Root Mean Square errors for the learning and test errors calculated on the basis of the actual data, the best-quality MLP 3-5-1 network for the metering of Z-factors and the new CDM methods for the metering of calorific values were experimentally selected. The Bayesian regularized MLPNN (BR-MLPNN) 3-5-1 network showed that the Z-factors of natural gas have a maximum relative error of -0.44%, and the new CDM method revealed calorific values with a maximum relative error of 1.90%. In addition, three local tests revealed that the maximum relative error of the daily cumulative amount of natural gas energy was 2.39%.

[Current situation and related of overweight and obesity in children aged 3-6 years old in Urumqi City in 2021].

OBJECTIVE: To understand the current situation and related factors of overweight and obesity in children aged 3-6 years old in Urumqi City. METHODS: From October to December 2021, a questionnaire survey was conducted on the general information of 1897 children and their fathers or mothers from 10 kindergartens in Urumqi City by stratified cluster sampling, and the height and weight of the children were measured. SPSS 25.0 was used for χ~2 test and Logistic regression analysis. RESULTS: There were 1897 children out of which 961(50.66%) were boys, 936(49.34%) were girls, 334(17.60%) were 3 years old, 592(31.21%)were 4 years old, 667(35.16%) were 5 years old, and 304(16.03%) were 6 years old. The prevalence rate of obesity and overweight in children aged 3-6 years old was 31.21%(592). Single factor analysis showed that child's age, the child's sex, the child's dietary habits, whether the child's father had a family history of obesity, whether the child's mother had a family history of obesity, whether the child's mother suffered from hypertension during pregnancy, whether the child's father smoked, whether the child's mother smoked during pregnancy(including passive smoking), the child's family per capita monthly income, the child's family structure type, and the child's mother's pregnancy age were all statistically significant(P<0.05 or P<0.01). The logistic regression analysis showed that child's age, the child's sex, the child's dietary habits, whether the child's father had a family history of obesity, whether the child's mother had a family history of obesity, whether the child's mother suffered from hypertension during pregnancy, whether the child's father smoked, whether the child's mother smoked during pregnancy(including passive smoking), the child's family structure type, and the child's mother's pregnancy age were overweight and obesity children aged 3-6 years old of related factors in Urumqi(P<0.05 or P<0.01). CONCLUSION: The detection rate of overweight and obesity in children aged 3-6 years old in Urumqi City is high.

[Correlation of neck circumference with body mass index in preschool children]. / å­¦é¾„å‰å„¿ç«¥é¢ˆå›´ä¸Žä½“é‡æŒ‡æ•°çš„ç›¸å ³æ€§.

OBJECTIVES: To study the correlation between neck circumference and body mass index and the value of neck circumference in identifying overweight and obesity in preschool children. METHODS: The stratified cluster sampling method was used to recruit 3 719 children under 7 years from 10 kindergartens in Urumqi, China. General data were collected, and physical measurements were performed. A Pearson correlation analysis was used to evaluate the correlation between neck circumference and body mass index. The receiver operating characteristic (ROC) curve was used to assess the accuracy of neck circumference in identifying overweight/obesity. The Kappa consistency test was used to assess the consistency of neck circumference and body mass index in identifying overweight/obesity. RESULTS: There was a positive correlation between neck circumference and body mass index in boys and girls of all ages (r≥0.50, P<0.001). According to body mass index as the criteria for overweight/obesity, the children were divided into an overweight/obesity group and a non-overweight/obesity group, and the analysis showed that the overweight/obesity group had a significantly larger neck circumference than the non-overweight/obesity group (P<0.001). The ROC curve analysis showed that neck circumference had an area under the ROC curve of >0.7 in identifying overweight/obesity for boys and girls. The Kappa consistency test showed that the neck circumference and body mass index had a Kappa value of >0.40 in identifying overweight/obesity in boys and girls of all ages. CONCLUSIONS: Neck circumference is positively correlated to body mass index, and neck circumference can be used to identify overweight/obesity in preschool children.

Tunable electronic properties of BSe-MoS2/WS2 heterostructures for promoted light utilization.

With applications in high performance electronics, photovoltaics, and catalysis, two-dimensional (2D) transition metal dichalcogenides (TMDCs) attract extensive attention due to their extraordinary physical properties. People have focused on TMDC-based materials for years, while the low mobility greatly hinders their further application. TMDC-based heterostructures with tunable band alignment have been experimentally confirmed to be feasible for photoelectronic devices or photocatalysts. Based on the density functional theory (DFT), there are four discoveries in this work: (1) we propose two new heterostructures based on BSe and MoS2/WS2 that have quite low mismatches and intrinsic type-II alignments. (2) Even though the VBM of BSe-MoS2 are completely contributed by BSe, the heterostructure is still endowed with a lower effective mass and a better transport characteristic in comparison with pristine structures. (3) A promoted absorption ability and a better transport characteristic oppose each other and the two characteristics cannot be obtained at the same time. (4) Tension strained structures can induce promoted light absorption in the solar spectrum and the predicted efficiency of the BSe-MoS2 bilayer can be as high as ∼19.3%, when the external electric field is applied. This theoretical survey proves that BSe-MoS2/WS2 with high flexibility and tunability are potential candidates for novel electronic devices and photocatalysts.

Efficient photoelectrochemical overall water-splitting of MoS2/g-C3N4 n-n type heterojunction film.

The construction of heterojunctions has attracted considerable attention among the various strategies of water-splitting for hydrogen evolution due to their band structure advantages. In this research, we combined chemical vapor deposition and pulsed laser deposition to fabricate MoS2/g-C3N4 heterojunction films on indium-tin oxide glass substrates, and we studied the photoelectrochemical (PEC) performance. The x-ray diffraction, x-ray photoelectron spectroscopy (XPS), and scanning electron microscope characterizations suggested the successful preparation of MoS2/g-C3N4 heterojunction films. In particular, the shifts of the peak positions in the XPS spectra indicated the formation of a strong interaction between the g-C3N4 and MoS2 films. After depositing MoS2 on the g-C3N4 film, the visible-light absorption was enhanced and broadened, the electrical conductivity improved, and the intensity of the photoluminescence peak decreased. As a result, the greater generation, faster transport, and lower recombination rate of electrons and holes caused the heterojunction films to show higher PEC performance. More importantly, the obtained MoS2/g-C3N4 film was confirmed to be an n-n type heterojunction and to have a typical type-II band structure, which could indeed suppress the recombination and promote the separation, transfer, and transport of photogenerated electron-holes. Finally, the obtained MoS2/g-C3N4 film successfully achieved the overall water-splitting and the H2 evolution rate when the visible-light radiation reached 252 µmol/h.

Development of an LC-MS/MS method for simultaneous quantitative analysis of macromolecular pharmaceutical adjuvant 2-hydroxypropyl-ß-cyclodextrin and active pharmaceutical ingredients butylphthalide in rat plasma.

Hydroxypropyl-ß-cyclodextrin, which possesses a high water solubility and low hemolycity, is widely used as a solubilizer and an excipient. It had also been reported that hydroxypropyl-ß-cyclodextrin has the activity of regulating lipid homeostasis. In order to further understand the metabolism, the primary focus was to establish a quantitative method for hydroxypropyl-ß-cyclodextrin. The analytes were extracted from plasma by protein precipitation with methanol and then carried out on a Waters CORTECS T3 column in the gradient elution of pure water and methanol. Finally, liquid chromatography-tandem mass spectrometry was applied in multiple reaction monitoring mode to complete the quantitative analysis of hydroxypropyl-ß-cyclodextrin. This validated method had been successfully applied to investigate the interaction between hydroxypropyl-ß-cyclodextrin and butylphthalide in vivo by optimizing the extraction reagent, simplifying the experimental procedure, and improving the sensitivity while considering the difference of drug chemical properties. Results showed that the inclusion of hydroxypropyl-ß-cyclodextrin with butylphthalide significantly improved the pharmacokinetic behavior of free body hydroxypropyl-ß-cyclodextrin and 3-n-butylphthalide in vivo. It had been implied that the metabolism of hydroxypropyl-ß-cyclodextrin and the drug active ingredients could impact each other. It will help better application of hydroxypropyl-ß-cyclodextrin and the developed method might lay the foundation for development of hydroxypropyl-ß-cyclodextrin as a treatment drug for brain diseases.

Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation.

The vexing difficulty in distinguishing glioma from normal tissues is a major obstacle to prognosis. In an attempt to solve this problem, we used a joint strategy that combined targeted-cancer stem cells nanoparticles with precise photoacoustic and fluorescence navigation. We showed that traditional magnetic resonance imaging (MRI) did not represent the true morphology of tumors. Targeted nanoparticles specifically accumulated in the tumor area. Glioma was precisely revealed at the cellular level. Tumors could be non-invasively detected through the intact skull by fluorescence molecular imaging (FMI) and photoacoustic tomography (PAT). Moreover, PAT can be used to excise deep gliomas. Histological correlation confirmed that FMI imaging accurately delineated scattered tumor cells. The combination of optical PAT and FMI navigation fulfilled the promise of precise visual imaging in glioma detection and resection. This detection method was deeper and more intuitive than the current intraoperative pathology.

Primary desmoplastic small round cell tumor in the left orbit: a case report and literature review.

PURPOSE: Desmoplastic small round cell tumor is a rare malignant neoplasm that most often occurs in the abdomen or pelvis of young men. We herein describe a rare case of desmoplastic small round cell tumor arising from the left orbit in a 16-year-old male. METHODS AND RESULTS: A biopsy was performed and the histology showed the nests of tumor cells with small round cell morphology. The tumor cells showed immunopositivity for desmin, CD99, CD56, SMA, NSE, CgA, SYN, Ki67 and vimentin. Fluorescence in situ hybridization study using EWSR1 break-apart probe was positive for EWSR1 gene rearrangement. After complete surgical resection of the tumor, we did not find tumor recurrence or metastasis with one-year follow-up. Furthermore, a review of the relevant English literature has been discussed. CONCLUSIONS: In the present study, for the first time, we report a case of desmoplastic small round cell tumor which is located in the orbital region.

Alpha-synuclein levels in patients with multiple system atrophy: a meta-analysis.

PURPOSE: This study evaluates the relationship between multiple system atrophy and α-synuclein levels in the cerebrospinal fluid, plasma and neural tissue. METHOD: Literature search for relevant research articles was undertaken in electronic databases and study selection was based on a priori eligibility criteria. Random-effects meta-analyses of standardized mean differences in α-synuclein levels between multiple system atrophy patients and normal controls were conducted to obtain the overall and subgroup effect sizes. Meta-regression analyses were performed to evaluate the effect of age, gender and disease severity on standardized mean differences. RESULTS: Data were obtained from 11 studies involving 378 multiple system atrophy patients and 637 healthy controls (age: multiple system atrophy patients 64.14 [95% confidence interval 62.05, 66.23] years; controls 64.16 [60.06, 68.25] years; disease duration: 44.41 [26.44, 62.38] months). Cerebrospinal fluid α-synuclein levels were significantly lower in multiple system atrophy patients than in controls but in plasma and neural tissue, α-synuclein levels were significantly higher in multiple system atrophy patients (standardized mean difference: -0.99 [-1.65, -0.32]; p = 0.001). Percentage of male multiple system atrophy patients was significantly positively associated with the standardized mean differences of cerebrospinal fluid α-synuclein levels (p = 0.029) whereas the percentage of healthy males was not associated with the standardized mean differences of cerebrospinal fluid α-synuclein levels (p = 0.920). CONCLUSION: In multiple system atrophy patients, α-synuclein levels were significantly lower in the cerebrospinal fluid and were positively associated with the male gender.

Comparative Study of Metal Accumulation in Three Fish Species (Silurus asotus, Cyprinus carpio, and Carassius auratus auratus) from the Jinsha and Tuo Rivers Located Upstream of the Yangtze River, China.

The concentrations of lead, chromium, cadmium, arsenic, and mercury were analyzed in the muscle and liver (hepatopancreas) of three fish species (Silurus asotus, Cyprinus carpio, and Carassius auratus auratus) from the Jinsha and Tuo Rivers. The above mentioned metal concentrations in the muscles of the three fish species were below the permissible limits, indicating that these fishes are safe for human consumption. The concentration of mercury in the carnivorous fishes was higher than that in the omnivorous fishes. There was no significant difference in growth rate and the concentration of lead, chromium, cadmium, arsenic, and mercury among the fishes from Panzhihua and Fushun. In the two age groups, the concentration of mercury did not vary significantly with growth rate of fish. The relationship between heavy metal concentration and growth rate of fish varied with metal species, fish species, and fish tissue.

MnO2 Submicroparticles from Chinese Brush and Their Application in Treatment of Methylene Blue Contaminated Wastewater.

Eggshell membrane (ESM) is selected as biotemplate to prepare MnO2 submicroparticles (SMPs) using Chinese Brush with sodium hydroxide solution. The size with average 710 nm of the obtained materials is in good consistency with the microsructured biotemplate. An efficient and convenient absorbent for methylene blue (MB) is developed. The removal efficiency could reach up to 93% in 35 min under room temperature without pH adjusting owing to the excellent adsorption from ESM itself and hydroxyl group formed on the surface of MnO2 crystal in the aqueous solution. Materials on the membrane can be separated from the wastewater simply to avoid the secondary pollution caused by the leak of material. This interesting approach to MnO2 SMPs and facile operation for MB adsorption could open a new path to the submicro-materials based wastewater treatment.

Longitudinal associations between self-compassion, depression, and suicidal ideation in adolescent boys and girls.

This study aims to elucidate associations among self-compassion, depression, and suicidal ideation, particularly with respect to gender differences. Using a multigroup cross-lagged panel model, we conducted a longitudinal evaluation of 424 Chinese adolescents (55.85% boys; Mage = 18.02, SD = 0.73 at baseline). Our findings indicated that suicidal ideation at T1 positively predicted depression 6 months later, while negatively predicted self-compassion. However, self-compassion negatively predicted depression 6 months later, specifically in boys, but not in girls. Furthermore, self-compassion significantly mediated the relationship between suicidal ideation at T1 and depression at T2. This study helps to uncover the underlying relationships between self-compassion, depression, and suicidal ideation, and also provide a detailed insight into the differential effects of self-compassion on depression among boys and girls.

Abstract or concrete? The impact of regional typicality and advertising appeal types on consumption intention toward geographical indication products.

The essential characteristic of geographical indication products is the association of the products with their region of origin. However, consumers have different associations between products and their region of origin (i.e., different regional typicality) according to different geographical indication products. In this regard, this research aims to explore how to adopt supporting advertising appeal types to improve consumers' attitudes and intentions toward geographical indication products with different regional typicality. To this end, this article proposes and tests the interaction between regional typicality and advertising appeal types on consumption intention toward products and the underlying mechanism and boundary conditions of this effect. Using three studies, this research finds that the adoption of abstract (vs. concrete) appeal is more likely to enhance consumption intention toward products when the geographical indication products have high regional typicality. Moreover, the reverse is true when the geographical indication products have low regional typicality. Furthermore, the results show that processing fluency mediates the interaction effect. In addition, the high (low) regional typicality and abstract (concrete) appeal on consumption intention toward products are more significant in the distant (close) spatial distance condition. In this way, this research provides a new perspective for studying consumer behavior with respect to geographical indication products and has implications for promoting the sales of geographical indication products and enhancing the brand value of geographical indication.

Antimicrobial Resistance and New Antimicrobial Agents, A Review of the Literature.

Antibiotic resistance has progressively diminished the effectiveness of conventional antibiotics, necessitating the cessation of clinical treatment. Consequently, novel antibacterial agents are urgently needed. We review studies on antimicrobial agents published during 2002-2023. Most of these studies were published within the last 10 years. By analyzing recent articles on antibiotic resistance and the development of new antibacterial drugs, we showed that although drug resistance is inevitable, the issue is being addressed gradually via the discovery and clinical application of antimicrobial peptides, nanomaterial drugs, and bacteriophage therapy. In light of the emergence of antimicrobial resistance, the development of new antimicrobial agents will require innovation in a field that has relied on traditional methods of discovery and development.

Bismuth Iron Oxide Catalysts for Efficient CO2 Electroreduction to Formate.

Renewable energy-driven electrocatalytic CO2 reduction reaction (CO2RR) over bismuth-based catalysts shows great promise for converting CO2 into formic acid and formate while closing the carbon cycle. Herein, we report a high-performance BiFeO3/Bi25FeO40 precatalyst, which delivers a formate partial current density of 359.8 mA cm-2 and a formate formation rate of 6.71 mmol h-1 cm-2 in a flow cell at -0.75 V versus reversible hydrogen electrode (vs RHE). Furthermore, it shows stable formate production for 88 h at -0.64 V vs RHE with a total current density of 160 mA cm-2. The impressive electrocatalytic performance toward CO2RR to formate is likely ascribed to the synergistic effect of single Bi atoms and bimetallic BiFe nanoparticles present in close proximity after in situ electrochemical reconstruction of the BiFeO3/Bi25FeO40 precatalyst. This work presents new insights into the development of highly efficient Bi-based catalysts for the CO2RR.

Influence of ammonium nitrate on the crystallisation of ammonium sulfate.

This study aims to explore the influence mechanism of ammonium nitrate produced by ozone denitrification on the crystallisation of ammonium sulfate, a by-product of ammonia desulfurisation. The laser method was used to study the influence of ammonium nitrate on the solubility and metastable zone width of ammonium sulfate. An experiment on the influence of ammonium nitrate on the particle size of ammonium sulfate was designed, and the influence mechanism was explored through scanning electron microscopy and X-ray diffraction. The findings showed that the addition of ammonium nitrate increased the size and aspect ratio of ammonium sulfate crystals. The addition of ammonium nitrate inhibited the dissolution of ammonium sulfate and widened its metastable zone. The addition of ammonium nitrate covered the active sites of crystal nucleus growth, which inhibited the formation of crystal nuclei to a certain extent, and crystal growth dominated the crystallisation process. Moreover, the addition of ammonium nitrate induced the preferred orientation of the specific crystal plane of ammonium sulfate, and the addition of a small concentration of ammonium nitrate decreased the crystallinity of ammonium sulfate. The research results can provide a reference for crystallisation optimisation and quality improvement of ammonium sulfate in the ammonia desulfurisation process.

Association of sarcopenia and vitamin D deficiency with glucocorticoid-induced osteoporosis in Chinese patients with rheumatoid arthritis.

OBJECTIVES: The study aimed to explore the association of sarcopenia and vitamin D deficiency with glucocorticoid-induced osteoporosis (GIOP) in Chinese patients with rheumatoid arthritis (RA). METHOD: Skeletal muscle mass, serum 25(OH)D levels, and bone mineral density (BMD) were assessed. RESULTS: The prevalence of OP, sarcopenia, and vitamin D deficiency in RA patients was significantly higher than in controls (all P < 0.001). The percentage of GC use was 56.9%, and the prevalence of GIOP was 38.1% in 480 RA patients. The prevalence of OP in RA patients without sarcopenia was lower than that in RA patients with sarcopenia (P < 0.05). In RA patients with and without GC, the prevalence of OP in patients without sarcopenia was significantly lower than that in patients with sarcopenia (P < 0.001 and P < 0.05). Female sex (OR = 54.737; 95% CI: 7.103-421.809; P < 0.0001), age (OR = 1.078; 95% CI: 1.048-1.110; P < 0.0001), sarcopenia, and vitamin D deficiency (OR = 2.250; 95% CI: 1.246-64.065; P = 0.007) were risk factors for GIOP in RA patients. CONCLUSIONS: GIOP is associated with sarcopenia and vitamin D deficiency and is widespread among Chinese patients with RA. Key points ·Percentage of using GC and the prevalence of OP were all high in Chinese patients with RA. ·GIOP was widely existed in Chinese RA patients, which was associated with sarcoprnia and vitamin D deficiency.

Mortality from cerebrovascular diseases in China: Exploration of recent and future trends.

BACKGROUND: Cerebrovascular disease (CVD) ranks among the foremost factors responsible for mortality on a global scale. The mortality patterns of CVDs and temporal trends in China need to be well-illustrated and updated. METHODS: We collected mortality data on patients with CVD from Chinese Center for Disease Control and Prevention's Disease Surveillance Points (CDC-DSP) system. The mortality of CVD in 2020 was described by age, sex, residence, and region. The temporal trend from 2013 to 2019 was evaluated using joinpoint regression, and estimated rates of decline were extrapolated until 2030 using time series models. RESULTS: In 2019, the age-standardized mortality in China (ASMRC) per 100,000 individuals was 113.2. The ASMRC for males (137.7/10 5 ) and rural areas (123.0/10 5 ) were both higher when stratified by gender and urban/rural residence. The central region had the highest mortality (126.5/10 5 ), the western region had a slightly lower mortality (123.5/10 5 ), and the eastern region had the lowest mortality (97.3/10 5 ). The age-specific mortality showed an accelerated upward trend from aged 55-59 years, with maximum mortality observed in individuals over 85 years of age. The age-standardized mortality of CVD decreased by 2.43% (95% confidence interval, 1.02-3.81%) annually from 2013 to 2019. Notably, the age-specific mortality of CVD increased from 2013 to 2019 for the age group of over 85 years. In 2020, both the absolute number of CVD cases and the crude mortality of CVD have increased compared to their values in 2019. The estimated total deaths due to CVD were estimated to reach 2.3 million in 2025 and 2.4 million in 2030. CONCLUSION: The heightened focus on the burden of CVD among males, rural areas, the central and western of China, and individuals aged 75 years and above has emerged as a pivotal determinant in further decreasing mortalities, consequently presenting novel challenges to strategies for disease prevention and control.

Structural insights into histone exchange by human SRCAP complex.

Histone variant H2A.Z is found at promoters and regulates transcription. The ATP-dependent chromatin remodeler SRCAP complex (SRCAP-C) promotes the replacement of canonical histone H2A-H2B dimer with H2A.Z-H2B dimer. Here, we determined structures of human SRCAP-C bound to H2A-containing nucleosome at near-atomic resolution. The SRCAP subunit integrates a 6-subunit actin-related protein (ARP) module and an ATPase-containing motor module. The ATPase-associated ARP module encircles half of the nucleosome along the DNA and may restrain net DNA translocation, a unique feature of SRCAP-C. The motor module adopts distinct nucleosome binding modes in the apo (nucleotide-free), ADP-bound, and ADP-BeFx-bound states, suggesting that ATPase-driven movement destabilizes H2A-H2B by unwrapping the entry DNA and pulls H2A-H2B out of nucleosome through the ZNHIT1 subunit. Structure-guided chromatin immunoprecipitation sequencing analysis confirmed the requirement of H2A-contacting ZNHIT1 in maintaining H2A.Z occupancy on the genome. Our study provides structural insights into the mechanism of H2A-H2A.Z exchange mediated by SRCAP-C.