Concave Structural Carbon Co-Doped with Iron Atom Pairs and Nitrogen as Ultra-High Performance Catalyst Toward Oxygen Reduction.

It is crucial to rationally design and synthesize atomic-scale transition metal-doped carbon catalysts with high electrocatalytic activity to achieve a high-efficient oxygen reduction reaction (ORR). Herein, an electrocatalyst comprised of Fe-Fe dual atom pairs and N-doped concave carbon are reported (N-CC@Fe DA) that achieves ultrahigh electrocatalytic ORR activity. The catalyst is prepared by a gaseous doping approach, with zeolitic imidazolate framework-8 (ZIF-8) as the carbon framework precursor and cyclopentadienyliron dicarbonyl dimer as the Fe-Fe atom pair precursor. The catalyst exhibits high cathodic ORR catalytic performance in an alkaline Zn/air battery and proton exchange membrane fuel cell (PEMFC), yielding peak power densities of 241 mW cm-2 and 724 mW cm-2, respectively, compared to 127 mW cm-2 and 1.20 W cm-2 with conventional Pt/C catalysts as cathodes. The presence of Fe atom pairs coordinate with N atoms is revealed by X-ray photoelectron spectroscopy (XPS) and X-ray absorption spectroscopy (XAS) analysis, and Density Functional Theory (DFT) calculation results show that the Fe-Fe pair structure is beneficial for adsorbing oxygen molecules, activating the O─O bond, and desorbing OH* intermediates formed during oxygen reduction, resulting in a more efficient oxygen reaction. The findings may provide a new pathway for preparing ultra-high-performance doped carbon catalysts with Fe-Fe atom pair structures.

Hf and Co Dual Single Atoms Co-Doped Carbon Catalyst Enhance the Oxygen Reduction Performance.

Single-atom metal-doped M-N-C (M═Fe, Co, Mn, or Ni) catalysts exhibit excellent catalytic activity toward oxygen reduction reactions (ORR). However, their performance still has a large gap considering the demand for their practical applications. This study reports a high-performance dual single-atom doped carbon catalyst (HfCo-N-C), which is prepared by pyrolyzing Co and Hf co-doped ZIF-8 . Co and Hf are atomically dispersed in the carbon framework and coordinated with N to form Co-N4 and Hf-N4 active moieties. The synergetic effect between Co-N4 and Hf-N4 significantly enhance the catalytic activity and durability of the catalyst. In an acidic medium, the ORR half-wave potential (E1/2) of the catalyst is up to 0.82 V , which is much higher than that of the Co-N-C catalyst without Hf co-doping (0.80 V). The kinetic current density of the catalyst is up to 2.49 A cm-2 at 0.85 V , which is 1.74 times that of the Co-N-C catalyst without Hf co-doping. Moreover, the catalyst exhibits excellent cathodic performance in single proton exchange membrane fuel cells and Zn-air batteries. Furthermore, Hf co-doping can effectively suppress the formation of H2O2, resulting in significantly improved stability and durability.

Amorphous TiOx Stabilized Intermetallic Pt3Ti Nanocatalyst for Methanol Oxidation Reaction.

Intermetallic compounds, featuring atomically ordered structures, have emerged as a class of promising electrocatalysts for fuel cells. However, it remains a formidable challenge to controllably synthesize Pt-based intermetallics during the essential high-temperature annealing process as well as stabilize the nanoparticles (NPs) during the electrocatalytic process. Herein, we demonstrated a Ketjen black supported intermetallic Pt3Ti nanocatalyst coupled with amorphous TiOx species (Pt3Ti-TiOx/KB). The TiOx can not only confine Pt3Ti NPs during the synthesis and electrocatalytic process by a strong metal-oxide interaction but also promote the water dissociation for generating more OH species, thus facilitating the conversion of COad. The Pt3Ti-TiOx/KB showed a significantly enhanced mass activity (2.15 A mgPt-1) for the methanol oxidation reaction, compared with Pt3Ti/KB and Pt/C, and presented an impressively high mass activity retention (∼71%) after the durability test. This work provides an effective strategy of coupling Pt-based intermetallics with functional oxides for developing highly performed electrocatalysts.

High Performance Aqueous Zinc-Ion Batteries Developed by PANI Intercalation Strategy and Separator Engineering.

Aqueous zinc-ion batteries (ZIBs) have attracted burgeoning attention and emerged as prospective alternatives for scalable energy storage applications due to their unique merits such as high volumetric capacity, low cost, environmentally friendly, and reliable safety. Nevertheless, current ZIBs still suffer from some thorny issues, including low intrinsic electron conductivity, poor reversibility, zinc anode dendrites, and side reactions. Herein, conductive polyaniline (PANI) is intercalated as a pillar into the hydrated V2O5 (PAVO) to stabilize the structure of the cathode material. Meanwhile, graphene oxide (GO) was modified onto the glass fiber (GF) membrane through simple electrospinning and laser reduction methods to inhibit dendrite growth. As a result, the prepared cells present excellent electrochemical performance with enhanced specific capacity (362 mAh g-1 at 0.1 A g-1), significant rate capability (280 mAh g-1 at 10 A g-1), and admirable cycling stability (74% capacity retention after 4800 cycles at 5 A g-1). These findings provide key insights into the development of high-performance zinc-ion batteries.

Controllable Synthesis of 2D Materials by Electrochemical Exfoliation for Energy Storage and Conversion Application.

2D materials have captured much recent research interest in a broad range of areas, including electronics, biology, sensors, energy storage, and others. In particular, preparing 2D nanosheets with high quality and high yield is crucial for the important applications in energy storage and conversion. Compared with other prevailing synthetic strategies, the electrochemical exfoliation of layered starting materials is regarded as one of the most promising and convenient methods for the large-scale production of uniform 2D nanosheets. Here, recent developments in electrochemical delamination are reviewed, including protocols, categories, principles, and operating conditions. State-of-the-art methods for obtaining 2D materials with small numbers of layers-including graphene, black phosphorene, transition metal dichalcogenides and MXene-are also summarized and discussed in detail. The applications of electrochemically exfoliated 2D materials in energy storage and conversion are systematically reviewed. Drawing upon current progress, perspectives on emerging trends, existing challenges, and future research directions of electrochemical delamination are also offered.

Ultrathin Co-N-C Layer Modified Pt-Co Intermetallic Nanoparticles Leading to a High-Performance Electrocatalyst toward Oxygen Reduction and Methanol Oxidation.

The development of low platinum-based alloy electrocatalysts is crucial to accelerate the commercialization of fuel cells, yet remains a synthetic challenge and an incompatibility between activity and stability. Herein, a facile procedure to fabricate a high-performance composite that comprises Pt-Co intermetallic nanoparticles (IMNs) and Co, N co-doped carbon (Co-N-C) electrocatalyst is proposed. It is prepared by direct annealing of homemade carbon black-supported Pt nanoparticles (Pt/KB) covered with a Co-phenanthroline complex. During this process, most of Co atoms in the complex are alloyed with Pt to form ordered Pt-Co IMNs, while some Co atoms are atomically dispersed and doped in the framework of superthin carbon layer derived from phenanthroline, which is coordinated with N to form Co-Nx moieties. Moreover, the Co-N-C film obtained from complex is observed to cover the surface of Pt-Co IMNs, which prevent the dissolution and agglomeration of nanoparticles. The composite catalyst exhibits high activity and stability toward oxygen reduction reactions (ORR) and methanol oxidation reactions (MOR), delivering outstanding mass activities of 1.96 and 2.92 A mgPt -1 for ORR and MOR respectively, owing to the synergistic effect of Pt-Co IMNs and Co-N-C film. This study may provide a promising strategy to improve the electrocatalytic performance of Pt-based catalysts.

Significant Enhancement of the Capacity and Cycling Stability of Lithium-Rich Manganese-Based Layered Cathode Materials via Molybdenum Surface Modification.

Lithium-rich manganese-based layered cathode materials are considered to be one of the best options for next-generation lithium-ion batteries, owing to their ultra-high specific capacity (>250 mAh·g−1) and platform voltage. However, their poor cycling stability, caused by the release of lattice oxygen as well as the electrode/electrolyte side reactions accompanying complex phase transformation, makes it difficult to use this material in practical applications. In this work, we suggest a molybdenum surface modification strategy to improve the electrochemical performance of Li1.2Mn0.54Ni0.13Co0.13O2. The Mo-modified Li1.2Mn0.54Ni0.13Co0.13O2 material exhibits an enhanced discharge specific capacity of up to 290.5 mAh·g−1 (20 mA·g−1) and a capacity retention rate of 82% (300 cycles at 200 mA·g−1), compared with 261.2 mAh·g−1 and a 70% retention rate for the material without Mo modification. The significantly enhanced performance of the modified material can be ascribed to the formation of a Mo-compound-involved nanolayer on the surface of the materials, which effectively lessens the electrolyte corrosion of the cathode, as well as the activation of Mo6+ towards Ni2+/Ni4+ redox couples and the pre-activation of a Mo compound. This study offers a facile and effective strategy to address the poor cyclability of lithium-rich manganese-based layered cathode materials.

Antiperovskite Nitrides CuNCo3-xVx: Highly Efficient and Durable Electrocatalysts for the Oxygen-Evolution Reaction.

Perovskite oxides have attracted much attention for enabling the oxygen-evolution reaction (OER) over the past decades. Nevertheless, their poor conductivity is still a barrier hindering their use. Herein, we report a catalyst prototype of Co-based antiperovskite nitrides CuNCo3-xVx (0 ≤ x ≤ 1) to be a highly effective OER electrocatalyst. The synthesized CuNCo3-xVx exhibits greatly enhanced activity and stability toward the OER in alkaline medium. The CuNCo2.4V0.6 shows a mere 235 mV of overpotential to reach 10 mA cm-2, which is comparable to that of Ir/C (232 mV). More importantly, the CuNCo2.4V0.6 is more durable than the conventional Ir/C catalyst. The CuNCo2.4V0.6 catalyst enabled a Zn-air battery to exhibit a cycle life of 143 h with a much higher cell efficiency. The V-substituted CuNCo2.4V0.6 provides a higher content of the desirable Co3+ species in the post-OER catalyst, which ensures a high activity over a long-term operation. With these enhanced effects enabled by the compositional flexibility of CuNCo3-xVx antiperovskite nitride, a feasible strategy for optimizing an electrocatalyst with tunable properties is provided.

UIO-66-NH2 -Derived Mesoporous Carbon Catalyst Co-Doped with Fe/N/S as Highly Efficient Cathode Catalyst for PEMFCs.

Efficient, low-cost catalysts are desirable for the sluggish oxygen reduction reaction (ORR). Herein, UIO-66-NH2 -derived multi-element (Fe, S, N) co-doped porous carbon catalyst is reported, Fe/N/S-PC, with an octahedral morphology, a well-defined mesoporous structure, and highly dispersed doping elements, synthesized by a double-solvent diffusion-pyrolysis method (DSDPM). The morphology of the UIO-66-NH2 precursor is perfectly inherited by the derived carbon material, resulting in a high surface area, a well-defined mesoporous structure, and atomic-level dispersion of the doping elements. Fe/N/S-PC demonstrates outstanding catalytic activity and durability for the ORR in both alkaline and acidic solutions. In 0.1 m KOH, its half-potential reaches 0.87 V (vs reversible hydrogen electrode (RHE)), 30 mV more positive than that of a 20 wt% Pt/C catalyst. In 0.1 m HClO4 , it reaches 0.785 V (vs RHE), only 65 mV less than that of Pt/C. The catalyst also exhibits excellent performance in acidic hydrogen/oxygen proton exchange membrane fuel cells. A membrane electrode assembly (MEA) with the catalyst as the cathode reaches 700 mA·cm-2 at 0.6 V and a maximum power density of 553 mW·cm-2 , ranking it among the best MEAs with a nonprecious metal catalyst as the cathode.

An Isolated Zinc-Cobalt Atomic Pair for Highly Active and Durable Oxygen Reduction.

A competitive complexation strategy has been developed to construct a novel electrocatalyst with Zn-Co atomic pairs coordinated on N doped carbon support (Zn/CoN-C). Such architecture offers enhanced binding ability of O2 , significantly elongates the O-O length (from 1.23 Što 1.42 Å), and thus facilitates the cleavage of O-O bond, showing a theoretical overpotential of 0.335 V during ORR process. As a result, the Zn/CoN-C catalyst exhibits outstanding ORR performance in both alkaline and acid conditions with a half-wave potential of 0.861 and 0.796 V respectively. The in situ XANES analysis suggests Co as the active center during the ORR. The assembled zinc-air battery with Zn/CoN-C as cathode catalyst presents a maximum power density of 230 mW cm-2 along with excellent operation durability. The excellent catalytic activity in acid is also verified by H2 /O2 fuel cell tests (peak power density of 705 mW cm-2 ).

Transition Metal Nitride Coated with Atomic Layers of Pt as a Low-Cost, Highly Stable Electrocatalyst for the Oxygen Reduction Reaction.

The main challenges to the commercial viability of polymer electrolyte membrane fuel cells are (i) the high cost associated with using large amounts of Pt in fuel cell cathodes to compensate for the sluggish kinetics of the oxygen reduction reaction, (ii) catalyst degradation, and (iii) carbon-support corrosion. To address these obstacles, our group has focused on robust, carbon-free transition metal nitride materials with low Pt content that exhibit tunable physical and catalytic properties. Here, we report on the high performance of a novel catalyst with low Pt content, prepared by placing several layers of Pt atoms on nanoparticles of titanium nickel binary nitride. For the ORR, the catalyst exhibited a more than 400% and 200% increase in mass activity and specific activity, respectively, compared with the commercial Pt/C catalyst. It also showed excellent stability/durability, experiencing only a slight performance loss after 10,000 potential cycles, while TEM results showed its structure had remained intact. The catalyst's outstanding performance may have resulted from the ultrahigh dispersion of Pt (several atomic layers coated on the nitride nanoparticles), and the excellent stability/durability may have been due to the good stability of nitride and synergetic effects between ultrathin Pt layer and the robust TiNiN support.

Photoassisted Oxygen Reduction Reaction in H2 -O2 Fuel Cells.

The oxygen reduction reaction (ORR) is a key step in H2 -O2 fuel cells, which, however, suffers from slow kinetics even for state-of-the-art catalysts. In this work, by making use of photocatalysis, the ORR was significantly accelerated with a polymer semiconductor (polyterthiophene). The onset potential underwent a positive shift from 0.66 to 1.34 V, and the current was enhanced by a factor of 44 at 0.6 V. The improvement was further confirmed in a proof-of-concept light-driven H2 -O2 fuel cell, in which the open circuit voltage (Voc ) increased from 0.64 to 1.18 V, and the short circuit current (Jsc ) was doubled. This novel tandem structure combining a polymer solar cell and a fuel cell enables the simultaneous utilization of photo- and electrochemical energy, showing promising potential for applications in energy conversion and storage.

Lithium-Ion Conductive Coatings for Nickel-Rich Cathodes for Lithium-Ion Batteries.

Nickel (Ni)-rich cathodes are among the most promising cathode materials of lithium batteries, ascribed to their high-power density, cost-effectiveness, and eco-friendliness, having extensive applications from portable electronics to electric vehicles and national grids. They can boost the wide implementation of renewable energies and thereby contribute to carbon neutrality and achieving sustainable prosperity in the modern society. Nevertheless, these cathodes suffer from significant technical challenges, leading to poor cycling performance and safety risks. The underlying mechanisms are residual lithium compounds, uncontrolled lithium/nickel cation mixing, severe interface reactions, irreversible phase transition, anisotropic internal stress, and microcracking. Notably, they have become more serious with increasing Ni content and have been impeding the widespread commercial applications of Ni-rich cathodes. Various strategies have been developed to tackle these issues, such as elemental doping, adding electrolyte additives, and surface coating. Surface coating has been a facile and effective route and has been investigated widely among them. Of numerous surface coating materials, have recently emerged as highly attractive options due to their high lithium-ion conductivity. In this review, a thorough and comprehensive review of lithium-ion conductive coatings (LCCs) are made, aimed at probing their underlying mechanisms for improved cell performance and stimulating new research efforts.

High-performance atomic Co/N co-doped porous carbon catalysts derived from Co-doped metal-organic frameworks for oxygen reduction.

Improving the activity and durability of carbon-based catalysts is a key challenge for their application in fuel cells. Herein, we report a highly active and durable Co/N co-doped carbon (CoNC) catalyst prepared via pyrolysis of Co-doped zeolitic-imidazolate framework-8 (ZIF-8), which was synthesized by controlling the feeding sequence to enable Co to replace Zn in the metal-organic framework (MOF). The catalyst exhibited excellent oxygen reduction reaction (ORR) performance, while the half-wave potential decreased by only 8 mV after 5,000 accelerated stress test (AST) cycles in an acidic solution. Furthermore, the catalyst exhibited satisfactory cathodic catalytic performance when utilized in a hydrogen/oxygen single proton exchange membrane (PEM) fuel cell and a Zn-air battery, yielding maximum power densities of 530 and 164 mW cm-2, respectively. X-ray absorption spectroscopy (XAS) and high-angle annular dark field-scanning transmission electron microscopy (HAAD-STEM) analyses revealed that Co was present in the catalyst as single atoms coordinated with N to form Co-N moieties, which results in the high catalytic performance. These results show that the reported catalyst is a promising material for inclusion into future fuel cell designs.

Novel functionalized nano-TiO2 loading electrocatalytic membrane for oily wastewater treatment.

Membrane fouling is a critical problem in membrane filtration processes for water purification. Electrocatalytic membrane reactor (ECMR) was an effective method to avoid membrane fouling and improve water quality. This study focuses on the preparation and characterization of a novel functionalized nano-TiO(2) loading electrocatalytic membrane for oily wastewater treatment. A TiO(2)/carbon membrane used in the reactor is prepared by coating TiO(2) as an electrocatalyst via a sol-gel process on a conductive microporous carbon membrane. In order to immobilize TiO(2) on the carbon membrane, the carbon membrane is first pretreated with HNO(3) to generate the oxygen-containing functional groups on its surface. X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), and X-ray photoelectron spectroscopy (XPS) analyses are used to evaluate the morphology and microstructure of the membranes. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements are employed to illustrate the eletrochemical activity of the TiO(2)/carbon membrane. The membrane performance is investigated by treating oily wastewater. The oil removal rate increases with a decrease in the liquid hourly space velocity (LHSV) through the ECMR. The COD removal rate was 100% with a LHSV of 7.2 h(-1) and 87.4% with a LHSV of 21.6 h(-1) during the treatment of 200 mg/L oily water. It suggests that the synergistic effect of electrocatalytic oxidation and membrane separation in the ECMR plays a key role.

Explicit Solutions of MHD Flow and Heat Transfer of Casson Fluid over an Exponentially Shrinking Sheet with Suction.

In this study, the magnetohydrodynamic (MHD) flow and heat transfer of a Casson fluid over an exponentially shrinking sheet with suction is investigated using the homotopy analysis method (HAM). Different from previous numerical methods and analytical techniques, we have obtained an explicit formula solution to the presented nonlinear problem. The explicit solutions of f(η) and θ(η) are obtained and are valid in the whole domain. The changes in velocity and temperature profiles are studied in cases of different Casson fluid parameter γ, magnetic interaction parameter M, suction parameter s, and Prandtl number Pr. The convergent solutions are verified by comparison with the numerical results. In addition, the skin friction coefficient Cf and local Nusselt number Nux are analyzed using the analytic formulas of f″(0) and θ'(0), respectively. The analytical formulas help us intuitively analyze the influence of various parameters at the theoretical level. The effects of different physical quantities on Cf and Nux are thoroughly investigated.

Analytical solutions for the hydrogen atom in plasmas with electric, magnetic, and Aharonov-Bohm flux fields.

The combined effects of external electric, magnetic, and Aharonov-Bohm (AB) flux fields on the two-dimensional hydrogen atom embedded in both Debye and quantum plasmas modeled by the more general exponential cosine Coulomb (MGECSC) potential are investigated using the general analytic approach, namely the homotopy analysis method (HAM). The analytical convergent solutions are obtained for the ground state as well as excited states at both weak and strong intensity of the external fields. The influence of the screening parameters on the quantum levels are exhaustively explored in the presence of three external fields. It is worth emphasizing that our analytical HAM results have 4-10 digits of accuracy in comparison with the numerical results. In the framework of the HAM method, there is no any small parameter different from the perturbation. Owing to this advantage, the convergent accurate solutions always can be obtained by the HAM approach even for the strong external fields. There is no limit to the value of the parameters or the strength of the external fields. It is also observed that the combined effects of the external fields play an important role on the interaction potential profile and the applied external magnetic field is the most dominant in the hydrogen atomic system. Also note that the combined effect of the fields is stronger than individual effects in both Debye and quantum plasmas. The findings obtained by the HAM-based approach in this study shed substantial light on the more complicated problems in plasmas for the atomic systems or molecular physics.

Heterostructured Pd/Ti/Pd Thin Films as Highly Efficient Catalysts for Methanol and Formic Acid Oxidation.

Finding a highly efficient catalyst for proton exchange membrane fuel cells is still the subject of extensive research. This article describes heterostructured Pd/Ti/Pd bimetallic thin films prepared using a strain-release technology as electrocatalysts for fuel cells. With their particular structure, these materials exhibit intriguing electrocatalytic activity toward the oxidation of both methanol and formic acid, yielding current densities of 0.17 and 0.56 A mg-1Pd, much superior to that of the commercial Pd black catalyst. Moreover, the Pd/Ti/Pd thin films display a low onset oxidation potential and extremely high current retention in both acidic and alkaline media. The carbon monoxide poisoning resistance is also significantly enhanced, thus contributing to ultrahigh stability in the long-term electrocatalytic processes. Their encouraging performance implies that such composites could be potential materials for energy conversion in the fuel cell field.

Preparing PAMAM-NK4 nano complexes and examining their in vitro growth suppression effects in breast cancer.

BACKGROUND: This study sought to examine the suppression of the NK4 (which is a fragment that originates from the trypsin digestion of the hepatocyte growth factor) gene as mediated by new nano material polyamidoamine (PAMAM) dendrimers in the growth of breast cancer cells MDA-MB-231 and MCF-7, and the therapeutic effects in a nude mice model of transplanted tumor cell MDA-MB-231. METHODS: We built PAMAM-NK4 nano particles and detected the in vitro transfection rate. Nano complexes and blank plasmid PAMAM dendrimers were transfected to MDA-MB-231 and MCF-7 cells, respectively. The western-blotting method, MTT experiment method, and bead method were used to detect the effects of the nano complexes on NK4 protein expression, cell proliferation, and cell apoptosis. The nude mice model of transplanted tumor cell MDA-MB-231 comprised 40 nude female mice who were subject to injections. The mice were randomly divided into four groups, comprising 10 mice per group. The control, blank plasmid and treatment groups were subcutaneously injected with 0.2 mL of 0.9% NaCl (Sodium chloride) solution, 0.2 mL of plasmid solution (including 100 µg PAMAM pcDNA3.1(-) blank plasmid nano complexes) and 0.2 mL of plasmid solution (including PAMAM-NK4 100 µg) beside the tumor inoculation spot, respectively. The positive control group was intraperitoneally injected with 0.2 mL of doxorubicin solution, including 100 µg doxorubicin. Western blotting was used to detect the NK4 protein expression of the transplanted tumor tissues of the various groups. RESULTS: NK4 protein was successfully expressed in MDA-MB-231 and MCF-7 cells transfected with PAMAM-NK4 nano particles, and cell proliferation was suppressed and cell apoptosis was induced. The tumor volumes and masses of the treatment and positive control groups were obviously smaller than those of the control group. The differences were statistically significant (P<0.05). The treatment group had an obviously higher mean value of NK4 protein expression than the control group. The differences were statistically significant (P<0.05). CONCLUSIONS: PAMAM-NK4 nano complexes suppress the growth of the breast cancer cells MDA-MB-231 and MCF-7, and had a treatment effect on this tumor nude mice model of breast cancer cells.

The miR-1185-2-3p-GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1.

BACKGROUND: Phosphatidylinositol-4-phosphate-binding protein GOLPH3L is overexpressed in human ductal carcinoma of the breast, and its expression levels correlate with the prognosis of breast cancer patients. However, the roles of GOLPH3L in breast tumorigenesis remain unclear. METHODS: We assessed the expression and biological function of GOLPH3L in breast cancer by combining bioinformatic prediction, metabolomics analysis and RNA-seq to determine the GOLPH3L-related pathways involved in tumorigenesis. Dual-luciferase reporter assay and coimmunoprecipitation (Co-IP) were used to explore the expression regulation mechanism of GOLPH3L. RESULTS: We demonstrated that knockdown of GOLPH3L in human breast cancer cells significantly suppressed their proliferation, survival, and migration and suppressed tumor growth in vivo, while overexpression of GOLPH3L promoted aggressive tumorigenic activities. We found that miRNA-1185-2-3p, the expression of which is decreased in human breast cancers and is inversely correlated with the prognosis of breast cancer patients, is directly involved in suppressing the expression of GOLPH3L. Metabolomics microarray analysis and transcriptome sequencing analysis revealed that GOLPH3L promotes central carbon metabolism in breast cancer by stabilizing the p53 suppressor SERPINE1. CONCLUSIONS: In summary, we discovered a miRNA-GOLPH3L-SERPINE1 pathway that plays important roles in the metabolism of breast cancer and provides new therapeutic targets for human breast cancer.