Detalhe da pesquisa
1.
NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions.
Chembiochem
; 21(3): 315-319, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31283075
2.
Ultrahigh performance liquid chromatography methods facilitate the development of glucose-responsive insulin therapeutics.
Anal Bioanal Chem
; 412(2): 377-388, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31773226
3.
Site-Selective Synthesis of Insulin Azides and Bioconjugates.
Bioconjug Chem
; 30(4): 1127-1132, 2019 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30946565
4.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2069-2073, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284804
5.
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2063-2068, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284809
6.
Glucagon receptor antagonism induces increased cholesterol absorption.
J Lipid Res
; 56(11): 2183-95, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26373568
7.
Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Bioorg Med Chem Lett
; 25(22): 5402-8, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403928
8.
A novel series of indazole-/indole-based glucagon receptor antagonists.
Bioorg Med Chem Lett
; 25(19): 4143-7, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303893
9.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Nat Commun
; 15(1): 489, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216578
10.
Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity.
ACS Med Chem Lett
; 13(8): 1255-1261, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978702
11.
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Nat Commun
; 13(1): 942, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177603
12.
Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.
J Med Chem
; 65(7): 5593-5605, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35298158
13.
Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs.
Mol Pharmacol
; 80(6): 1156-65, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21937665
14.
Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.
Bioorg Med Chem Lett
; 20(3): 1298-301, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064714
15.
In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules.
ACS Omega
; 5(28): 17531-17542, 2020 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32715238
16.
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Bioorg Med Chem Lett
; 19(12): 3238-42, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19423344
17.
Author Correction: Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Nat Commun
; 15(1): 688, 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38263326
18.
Design, synthesis, and biological evaluation of new-generation taxoids.
J Med Chem
; 51(11): 3203-21, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18465846
19.
Annotated Bibliography of Dr. Arthur A. Patchett.
J Med Chem
; 66(23): 15567-15575, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38032081
20.
A glucose-responsive insulin therapy protects animals against hypoglycemia.
JCI Insight
; 3(1)2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29321379