Detalhe da pesquisa
1.
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.
Pharmacol Res
; 131: 150-163, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29477480
2.
Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.
J Chem Inf Model
; 55(4): 814-22, 2015 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25794351
3.
Probing the energy landscape of activation gating of the bacterial potassium channel KcsA.
PLoS Comput Biol
; 9(5): e1003058, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23658510
4.
Structural insights into trapping and dissociation of small molecules in K⺠channels.
J Chem Inf Model
; 54(11): 3218-28, 2014 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25297379
5.
Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model.
Pflugers Arch
; 464(4): 391-401, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22941337
6.
Drug trapping in hERG K+ channels: (not) a matter of drug size?
Medchemcomm
; 7(3): 512-518, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337337
7.
Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue.
Cardiovasc Res
; 99(1): 203-14, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625347
8.
In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channel.
PLoS One
; 6(12): e28778, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22194911
9.
Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein.
Atherosclerosis
; 219(1): 109-15, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21820657
10.
Statins: under investigation for increasing bone mineral density and augmenting fracture healing.
Expert Opin Investig Drugs
; 17(10): 1435-63, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18808306