Detalhe da pesquisa
1.
Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study.
Lancet Oncol
; 21(11): 1423-1432, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035459
2.
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Mol Cell
; 37(1): 102-11, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20129059
3.
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Nat Chem Biol
; 11(6): 432-7, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915199
4.
Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.
J Biol Chem
; 287(19): 15512-22, 2012 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22427669
5.
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Cancer Cell
; 36(1): 100-114.e25, 2019 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31257072
6.
A high-throughput liposome substrate assay with automated lipid extraction process for PI 3-kinase.
J Biomol Screen
; 13(9): 906-11, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18812570
7.
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
PLoS One
; 13(6): e0197372, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856759
8.
EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL.
Mol Cancer Ther
; 16(11): 2586-2597, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28835384
9.
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
ACS Med Chem Lett
; 6(6): 655-9, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101569
10.
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
Cancer Res
; 70(11): 4318-26, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20460535
11.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.
Protein Expr Purif
; 35(2): 218-24, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15135396