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PURPOSE: The objective of this systematic review and meta-analysis was to examine the impact of titanium base supported single implant restorations on peri-implant conditions. MATERIALS AND METHODS: Six randomized controlled trials (RCTs), comprising a total of 274 implants that met the inclusion criteria, were chosen for data analysis. A random effects model was employed for the metaanalysis. RESULTS: Data from this study revealed that the Ti-base group exhibited a slightly but statistically significant increase in peri-implant marginal bone loss (difference in means = 0.088, 95% confidence interval = 0.003 to 0.17, p = 0.041) compared to the one-piece-abutment group. These effects were consistent in the subgroup analysis of regular-threaded implants comparing to the microthreaded subgroup. However, no significant differences were observed between the Ti-base group and the abutment group concerning probing depth (PD), bleeding on probing (BOP), and the risk of prosthetic-related complications. CONCLUSIONS: The utilization of Ti-base in single-implant supported restoration is associated with a slight increase in peri-implant marginal bone loss, while other periimplant health parameters show no significant correlation. Therefore, to determine the impact of Tibase on peri-implant condition of single implant-supported restoration is insufficient based on the findings of this meta-analysis.
RESUMO
OBJECTIVES: Angiotensin I-converting enzyme (ACE), a type I cell surface zinc metallopeptidase, is differentially expressed in several malignancies and plays a role in tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior. We aimed to investigate the effects of ACE gene (rs1799752) variants on oral cancer risk. MATERIALS AND METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 32 was used to measure ACE gene polymorphisms in 88 patients with oral precancerous lesion (OPL), 186 33 patients with oral cancer, and 120 control subjects without any oral lesions. All study subjects were male 34 betel quid chewers. RESULTS: Patients with oral cancer or OPL had a higher frequency of the DD genotype than the control patients did. Oral cancer patients with the DD genotype had a significantly higher prevalence of lymph node metastases than patients with the II/ID genotype did. After adjusting for age, smoking, drinking, and betel quid chewing status, we found that individuals with the DD genotype of the ACE gene had a 5.46-fold and 3.13-fold higher risk of developing oral cancer or OPL, respectively, than those with the II genotype did. Furthermore, oral cancer patients with the DD genotype of the ACE gene had a 2.16-fold higher likelihood of lymph node metastasis. CONCLUSION: Our data suggest that the ACE gene polymorphisms may be associated with increased susceptibility to OPL and oral cancer and lymph node metastasis from oral cancer.