Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 24
Filtrar
Mais filtros

Base de dados
País/Região como assunto
Tipo de documento
Intervalo de ano de publicação
1.
Ergonomics ; 64(9): 1191-1204, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33830853

RESUMO

The determinants of energy saving phenomena reported for load carried on the head, back and in a doublepack remain unclear. This study compared the energetic, kinematic and kinetic responses to head (H), back (B) and doublepack (DP) loading. Fifteen volunteers walked on an instrumented treadmill at 3 km.h-1 with 0, 3, 12 and 20 kg in each loading method. Whole body motion, ground reaction forces (GRF) and metabolic cost were measured. H was less economical than B (p = 0.014) and DP (p = 0.010). H was also associated with increased step length (p = 0.045), decreased cadence (p = 0.001), greater trunk (p < 0.001) and hip (p < 0.001) extension and greater minimum vertical GRF (p = 0.001) than B and DP. In conclusion, no energy saving was found for head- or back-loading but economy may be improved with methods that cause smaller perturbations from unloaded walking. Practitioner summary: Energy saving phenomena have been reported for load carried on the head, back and in a doublepack, yet the determinants are unclear. This study shows that smaller perturbations from unloaded to loaded walking are associated with improved economy for certain load carriage conditions, such as the doublepack.


Assuntos
Tronco , Caminhada , Fenômenos Biomecânicos , Teste de Esforço , Marcha , Humanos , Suporte de Carga
2.
Ergonomics ; 61(9): 1216-1222, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29757714

RESUMO

It has been suggested that freedom of movement in the trunk could influence load carriage economy. This study aimed to compare the economy and sagittal plane trunk movements associated with three load carriage methods that constrain posture differently. Eighteen females walked at 3 km.h-1 with loads of 0, 3, 6, 9, 12, 15 and 20 kg carried on the back, back/front and head. Load carriage economy was assessed using the Extra Load Index (ELI). Change in sagittal plane trunk forward lean and trunk angle excursion from unloaded to loaded walking were assessed. Results show no difference in economy between methods (p = .483), despite differences in the change in trunk forward lean (p = .001) and trunk angle excursion (p = .021) from unloaded to loaded walking. We conclude that economy is not different among the three methods of load carriage, despite significant differences in sagittal plane trunk movements. Practitioner summary: This article shows, based on mean data, that there is no difference in economy among back, back/front and head-loading, despite differences in trunk movement. It is possible a combination of factors align to influence individual economy, rather than a single set of factors, applicable to all individuals for each method.


Assuntos
Dorso/fisiologia , Cabeça/fisiologia , Equilíbrio Postural/fisiologia , Tronco/fisiologia , Caminhada/fisiologia , Suporte de Carga/fisiologia , Adulto , Análise de Variância , Teste de Esforço , Feminino , Humanos , Movimento , Postura , África do Sul , Adulto Jovem
3.
Eur J Appl Physiol ; 117(3): 417-430, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28154976

RESUMO

PURPOSE: The purpose of this experiment was to evaluate the effect of load carriage in a range of temperatures to establish the interaction between cold exposure, the magnitude of change from unloaded to loaded walking and gradient. METHODS: Eleven participants (19-27 years) provided written informed consent before performing six randomly ordered walking trials in six temperatures (20, 10, 5, 0, -5, and -10 °C). Trials involved two unloaded walking bouts before and after loaded walking (18.2 kg) at 4 km · h-1, on 0 and 10% gradients in 4 min bouts. RESULTS: The change in absolute oxygen consumption (V̇O2) from the first unloaded bout to loaded walking was similar across all six temperatures. When repeating the second unloaded bout, V̇O2 at both -5 and -10 °C was greater compared to the first. At -10 °C, V̇O2 was increased from 1.60 ± 0.30 to 1.89 ± 0.51 L · min-1. Regardless of temperature, gradient had a greater effect on V̇O2 and heart rate (HR) than backpack load. HR was unaffected by temperature. Stride length (SL) decreased with decreasing temperature, but trunk forward lean was greater during cold exposure. CONCLUSION: Decreased ambient temperature did not influence the magnitude of change in V̇O2 from unloaded to loaded walking. However, in cold temperatures, V̇O2 was significantly higher than in warm conditions. The increased V̇O2 in colder temperatures at the same exercise intensity is predicted to ultimately lead to earlier onset of fatigue and cessation of exercise. These results highlight the need to consider both appropriate clothing and fitness during cold exposure.


Assuntos
Resposta ao Choque Frio , Marcha , Consumo de Oxigênio , Postura , Caminhada/fisiologia , Suporte de Carga/fisiologia , Temperatura Baixa , Feminino , Humanos , Masculino , Adulto Jovem
4.
Ergonomics ; 60(9): 1250-1254, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28092227

RESUMO

The aim of this study was to measure the reliability of the extra load index (ELI) as a method for assessing relative load carriage economy. Seventeen volunteers (12 males, 5 females) performed walking trials at 3 km·h-1, 6 km·h-1 and a self-selected speed. Trial conditions were repeated 7 days later to assess test-retest reliability. Trials involved four 4-minute periods of walking, each separated by 5 min of rest. The initial stage was performed unloaded followed in a randomised order by a second unloaded period and walking with backpacks of 7 and 20 kg. Results show ELI values did not differ significantly between trials for any of the speeds (p = 0.46) with either of the additional loads (p = 0.297). The systematic bias, limits of agreement and coefficients of variation were small in all trial conditions. We conclude the ELI appears to be a reliable measure of relative load carriage economy. Practitioner Summary: This paper demonstrates that the ELI is a reliable measure of load carriage economy at a range of walking speeds with both a light and heavy load. The ELI, therefore, represents a useful tool for comparing the relative economy associated with different load carriage systems.


Assuntos
Teste de Caminhada/estatística & dados numéricos , Velocidade de Caminhada , Suporte de Carga , Carga de Trabalho/estatística & dados numéricos , Adulto , Feminino , Voluntários Saudáveis , Humanos , Masculino , Reprodutibilidade dos Testes
5.
J Strength Cond Res ; 28(7): 1839-48, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24345969

RESUMO

It was the aim of the present study to expand on previous correlation analyses that have attempted to identify factors that influence performance of jumping, sprinting, and changing direction. This was achieved by using a regression approach to obtain linear models that combined anthropometric, strength, and other biomechanical variables. Thirty rugby union players participated in the study (age: 24.2 ± 3.9 years; stature: 181.2 ± 6.6 cm; mass: 94.2 ± 11.1 kg). The athletes' ability to sprint, jump, and change direction was assessed using a 30-m sprint, vertical jump, and 505 agility test, respectively. Regression variables were collected during maximum strength tests (1 repetition maximum [1RM] deadlift and squat) and performance of fast velocity resistance exercises (deadlift and jump squat) using submaximum loads (10-70% 1RM). Force, velocity, power, and rate of force development (RFD) values were measured during fast velocity exercises with the greatest values produced across loads selected for further analysis. Anthropometric data, including lengths, widths, and girths were collected using a 3-dimensional body scanner. Potential regression variables were first identified using correlation analyses. Suitable variables were then regressed using a best subsets approach. Three factor models generally provided the most appropriate balance between explained variance and model complexity. Adjusted R values of 0.86, 0.82, and 0.67 were obtained for sprint, jump, and change of direction performance, respectively. Anthropometric measurements did not feature in any of the top models because of their strong association with body mass. For each performance measure, variance was best explained by relative maximum strength. Improvements in models were then obtained by including velocity and power values for jumping and sprinting performance, and by including RFD values for change of direction performance.


Assuntos
Desempenho Atlético/fisiologia , Tamanho Corporal , Força Muscular , Corrida/fisiologia , Adulto , Fenômenos Biomecânicos , Teste de Esforço , Futebol Americano/fisiologia , Humanos , Modelos Lineares , Masculino , Movimento/fisiologia , Adulto Jovem
6.
J Strength Cond Res ; 26(4): 906-13, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22446664

RESUMO

One of the most popular exercises for developing lower-body muscular power is the weighted vertical jump. The present study sought to examine the effect of altering the position of the external load on the kinematics and kinetics of the movement. Twenty-nine resistance-trained rugby union athletes performed maximal effort jumps with 0, 20, 40, and 60% of their squat 1 repetition maximum (1RM) with the load positioned (a) on the posterior aspect of the shoulder using a straight barbell and (b) at arms' length using a hexagonal barbell. Kinematic and kinetic variables were calculated through integration of the vertical ground reaction force data using a forward dynamics approach. Performance of the hexagonal barbell jump resulted in significantly (p < 0.05) greater values for jump height, peak force, peak power, and peak rate of force development compared with the straight barbell jump. Significantly (p < 0.05) greater peak power was produced during the unloaded jump compared with all trials where the external load was positioned on the shoulder. In contrast, significantly (p < 0.05) greater peak power was produced when using the hexagonal barbell combined with a load of 20% 1RM compared with all other conditions investigated. The results suggest that weighted vertical jumps should be performed with the external load positioned at arms' length rather than on the shoulder when attempting to improve lower-body muscular performance.


Assuntos
Futebol Americano/fisiologia , Extremidade Inferior/fisiologia , Postura/fisiologia , Levantamento de Peso/fisiologia , Adulto , Atletas , Fenômenos Biomecânicos/fisiologia , Humanos , Masculino , Movimento/fisiologia , Força Muscular/fisiologia , Músculo Esquelético/fisiologia , Treinamento Resistido , Adulto Jovem
7.
J Strength Cond Res ; 26(7): 1805-16, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22505136

RESUMO

The purpose of this study was to compare the biomechanics of the traditional squat with 2 popular exercise variations commonly referred to as the powerlifting squat and box squat. Twelve male powerlifters performed the exercises with 30, 50, and 70% of their measured 1 repetition maximum (1RM), with instruction to lift the loads as fast as possible. Inverse dynamics and spatial tracking of the external resistance were used to quantify biomechanical variables. A range of significant kinematic and kinetic differences (p < 0.05) emerged between the exercises. The traditional squat was performed with a narrow stance, whereas the powerlifting squat and box squat were performed with similar wide stances (48.3 ± 3.8, 89.6 ± 4.9, 92.1 ± 5.1 cm, respectively). During the eccentric phase of the traditional squat, the knee traveled past the toes resulting in anterior displacement of the system center of mass (COM). In contrast, during the powerlifting squat and box squat, a more vertical shin position was maintained, resulting in posterior displacements of the system COM. These differences in linear displacements had a significant effect (p < 0.05) on a number of peak joint moments, with the greatest effects measured at the spine and ankle. For both joints, the largest peak moment was produced during the traditional squat, followed by the powerlifting squat, then box squat. Significant differences (p < 0.05) were also noted at the hip joint where the largest moment in all 3 planes were produced during the powerlifting squat. Coaches and athletes should be aware of the biomechanical differences between the squatting variations and select according to the kinematic and kinetic profile that best match the training goals.


Assuntos
Movimento/fisiologia , Postura , Levantamento de Peso/fisiologia , Adulto , Tornozelo/fisiologia , Fenômenos Biomecânicos/fisiologia , Quadril/fisiologia , Humanos , Joelho/fisiologia , Masculino , Coluna Vertebral/fisiologia , Adulto Jovem
8.
J Strength Cond Res ; 25(7): 2000-9, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21659894

RESUMO

The purpose of the investigation was to compare the kinematics and kinetics of the deadlift performed with 2 distinct barbells across a range of submaximal loads. Nineteen male powerlifters performed the deadlift with a conventional straight barbell and a hexagonal barbell that allowed the lifter to stand within its frame. Subjects performed trials at maximum speed with loads of 10, 20, 30, 40, 50, 60, 70, and 80% of their predetermined 1-repetition maximum (1RM). Inverse dynamics and spatial tracking of the external resistance were used to quantify kinematic and kinetic variables. Subjects were able to lift a heavier 1RM load in the hexagonal barbell deadlift (HBD) than the straight barbell deadlift (SBD) (265 ± 41 kg vs. 245 ± 39 kg, p < 0.05). The design of the hexagonal barbell significantly altered the resistance moment at the joints analyzed (p < 0.05), resulting in lower peak moments at the lumbar spine, hip, and ankle (p < 0.05) and an increased peak moment at the knee (p < 0.05). Maximum peak power values of 4,388 ± 713 and 4,872 ± 636 W were obtained for the SBD and HBD, respectively (p < 0.05). Across the submaximal loads, significantly greater peak force, peak velocity and peak power values were produced during the HBD compared to during the SBD (p < 0.05). The results demonstrate that the choice of barbell used to perform the deadlift has a significant effect on a range of kinematic and kinetic variables. The enhanced mechanical stimulus obtained with the hexagonal barbell suggests that in general the HBD is a more effective exercise than the SBD.


Assuntos
Treinamento Resistido/instrumentação , Equipamentos Esportivos , Levantamento de Peso/fisiologia , Adulto , Articulação do Tornozelo/fisiologia , Fenômenos Biomecânicos , Estudos Transversais , Articulação do Quadril/fisiologia , Humanos , Cinética , Articulação do Joelho/fisiologia , Vértebras Lombares , Masculino , Postura , Coluna Vertebral/fisiologia , Adulto Jovem
9.
J Strength Cond Res ; 25(11): 3163-74, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21993040

RESUMO

The purpose of this study was to investigate whether the deadlift could be effectively incorporated with explosive resistance training (ERT) and to investigate whether the inclusion of chains enhanced the suitability of the deadlift for ERT. Twenty-three resistance trained athletes performed the deadlift with 30, 50, and 70% 1-repetition maximum (1RM) loads at submaximal velocity, maximal velocity (MAX), and MAX with the inclusion of 2 chain loads equal to 20 or 40% of the subjects' 1RM. All trials were performed on force platforms with markers attached to the barbell to calculate velocity and acceleration using a motion capture system. Significant increases in force, velocity, power, rate of force development, and length of the acceleration phase (p < 0.05) were obtained when repetition velocity increased from submaximal to maximal. During MAX repetitions with a constant resistance, the mean length of the acceleration phase ranged from 73.2 (±7.2%) to 84.9 (±12.2%) of the overall movement. Compared to using a constant resistance, the inclusion of chains enabled greater force to be maintained to the end of the concentric action and significantly increased peak force and impulse (p < 0.05), while concurrently decreasing velocity, power, and rate of force development (p < 0.05). The effects of chains were influenced by the magnitude of the chain and barbell resistance, with greater increases and decreases in mechanical variables obtained when heavier chain and barbell loads were used. The results of the investigation suggest that the deadlift can be incorporated effectively in ERT programs. Coaches and athletes should be aware that the inclusion of heavy chains may have both positive and negative effects on kinematics and kinetics of an exercise.


Assuntos
Treinamento Resistido/métodos , Levantamento de Peso/fisiologia , Adulto , Atletas , Fenômenos Biomecânicos/fisiologia , Feminino , Futebol Americano/fisiologia , Humanos , Masculino , Força Muscular/fisiologia , Músculo Esquelético/fisiologia , Treinamento Resistido/instrumentação , Adulto Jovem
10.
J Bone Miner Metab ; 28(2): 185-90, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19629620

RESUMO

Although the influence of weight-bearing activity on bone mass has been widely investigated in white women, few studies have been conducted in black, African populations. We investigated bone mineral density (BMD) in black South African women, with and without a history of load-carrying on the head. We also investigated whether load carrying may offer protection against low BMD in users of injectable progestin contraception (IPC). Participants were 32 black, South African women (22.4 +/- 3.2 years). Load carrying history was determined by questionnaire and interview; participants were grouped as load carriers (LC; n = 18) or non-load carriers (NLC; n = 14). Ten women were using IPC and 6 were load-carriers. Total body (TB), lumbar spine (LS) and total hip (H) BMD were measured by dual energy X-ray absorptiometry. There were no differences in BMD between LC and NLC, and after controlling for age and BMI using two-tailed partial correlations. IPC users had lower BMD at all sites compared to non-IPC users (p < 0.05) and there were no associations between load carrying and BMD in this group. When IPC users were excluded from analysis, LC had higher LS BMD than NLC (p < 0.005). Correlations were found between the weight of load carried and LS BMD (r = 0.743, p < 0.005), and between years of load carrying and LS and TB BMD (r = 0.563, r = 0.538, respectively; both p < 0.05). Load carrying on the head may offer osteogenic benefits to the spine but these benefits did not appear in women using IPC.


Assuntos
População Negra , Densidade Óssea/fisiologia , Cabeça , Pré-Menopausa , Suporte de Carga/fisiologia , Absorciometria de Fóton , Adolescente , Adulto , Antropometria , Reabsorção Óssea/prevenção & controle , Anticoncepcionais Femininos/administração & dosagem , Implantes de Medicamento , Feminino , Humanos , Projetos Piloto , Progestinas/administração & dosagem , Estudos Retrospectivos , África do Sul , Estatística como Assunto , Inquéritos e Questionários , Imagem Corporal Total , Adulto Jovem
11.
Ergonomics ; 53(12): 1500-4, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21108086

RESUMO

The Extra Load Index (ELI) has been proposed as a suitable method of assessing the relative economy of load carriage systems. The purpose of this study was to determine, based on empirical evidence, that the ELI can accommodate variations in both body composition and added load. In total, 30 women walked carrying loads of up to 70% body mass at self-selected walking speeds whilst expired air was collected. In addition, each of the women had body composition assessed via dual energy X-ray absorptiometry. Results show that the ELI is independent of body composition variables, the magnitude of additional loads and the speed of progression. Consequently, it is suggested that it represents an appropriate method of comparing load carriage systems in both scientific and commercial arenas. STATEMENT OF RELEVANCE: This paper demonstrates that ELI is independent of body composition, added load and speed and is therefore an appropriate method to generalise comparisons of load carriage systems. It has the advantage of being easily understood by manufacturers and consumers whilst retaining appropriate scientific precision.


Assuntos
Ergonomia , Suporte de Carga , Adulto , Antropometria , Composição Corporal , Feminino , Humanos , Consumo de Oxigênio , Caminhada , Adulto Jovem
12.
Appl Ergon ; 82: 102968, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31600713

RESUMO

Equivocal findings exist for the economy associated with load carried close to the body's centre of mass. Individual variation could explain some of the equivocal findings. This research aimed to examine the extent of individual variation in loaded walking economy. Eighteen females carried load on the back, head and split between the front and back. Individual variation in relative load carriage economy (ELI) was primarily assessed using standard deviation, coefficients of variation (CV) and intraclass correlation coefficients (ICC). There was large inter-individual variation in ELI values with highest mean CV's of 16%, 12% and 10% for head-, back- and combined front and back-loading. Mean ELI values were not significantly different between methods. The large amount of individual variation found here suggests future load carriage research should account for individual variation, particularly when considering sample size and when making inferences on the economy associated with different types of load carriage using group mean data.


Assuntos
Suporte de Carga/fisiologia , Dorso/fisiologia , Fenômenos Biomecânicos , Índice de Massa Corporal , Feminino , Cabeça/fisiologia , Humanos , Caminhada/fisiologia , Adulto Jovem
13.
J Strength Cond Res ; 23(2): 380-4, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19197205

RESUMO

The primary objective of this study was to investigate current powerlifting training methods in light of anecdotal evidence purporting increased similarity with the explosive training practices of weightlifters. The study also assessed the prevalence of contemporary training practices frequently recommended for powerlifters in the popular literature. A 20-item survey was distributed to 32 elite British powerlifters at an International competition. The subject group included multiple national, international, and commonwealth champions and record holders. Based on 2007 competition results, the average Wilks score of the group was 450.26 +/- 34.7. The response rate for the surveys was 88% (28 of 32). The survey was sectioned into 6 areas of inquiry: a) repetition speed, b) explosive training load, c) resistance materials used, d) adjunct power training methods, e) exercise selection, and f) training organization. The results demonstrate that the majority of powerlifters train with the intention to explosively lift maximal and submaximal loads (79 and 82%, respectively). Results revealed that 39% of the lifters regularly used elastic bands and that 57% incorporated chains in their training. Evidence for convergence of training practices between powerlifters and weightlifters was found when 69% of the subjects reported using the Olympic lifts or their derivatives as part of their powerlifting training. Collectively, the results demonstrate that previous notions of how powerlifters train are outdated. Contemporary powerlifters incorporate a variety of training practices that are focused on developing both explosive and maximal strength.


Assuntos
Exercício Físico , Levantamento de Peso , Coleta de Dados , Humanos , Masculino , Reino Unido , Levantamento de Peso/fisiologia
14.
Aerosp Med Hum Perform ; 89(11): 952-960, 2018 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-30352647

RESUMO

BACKGROUND: While respiratory muscle fatigue is present following load carriage activity at sea level, the effect of environmental conditions on respiratory strength while undertaking load carriage is unknown.METHODS: The effect of thoracic load carriage during walks (5.5 km) in four environments [(thermo-neutral sea level (SL), -10°C (C), 4300 m (H) and 4300 m at -10°C (HC)] was evaluated on respiratory muscle fatigue. Ten subjects completed eight self-paced randomized treadmill walks comprising a variety of gradients, unloaded and loaded (18.2 kg), across the four environments. Respiratory muscle strength was measured via maximal inspiratory pressure (PImax) and expiratory pressure (PEmax) assessments.RESULTS: Submaximal walking in HC elicited respiratory muscle fatigue when compared to SL. Inspiratory muscle fatigue was independent of load. The relative change in PImax from baseline was significantly greater in HC compared to SL (9.6% vs. 1.3%). PEmax showed a significant reduction during HC (-22.3 cmH2O, -14.4%) when compared to the other three environments.CONCLUSION: These results highlight the need to focus on respiratory muscle strength in preparation for exercise in cold hypoxic conditions.Hinde K, Low C, Lloyd R, Cooke C. Interaction between ambient temperature, hypoxia, and load carriage on respiratory muscle fatigue. Aerosp Med Hum Perform. 2018; 89(11):952-960.


Assuntos
Altitude , Temperatura Baixa , Hipóxia/fisiopatologia , Fadiga Muscular/fisiologia , Músculos Respiratórios/fisiologia , Suporte de Carga/fisiologia , Adulto , Feminino , Humanos , Masculino , Temperatura , Adulto Jovem
15.
Radiat Prot Dosimetry ; 118(4): 412-20, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16332916

RESUMO

Chelators are used to promote excretion of actinides and some other metals, but few are orally effective. The relative efficacies of orally administered triethylenetetraminepentaacetic acids (TT) with varying lipophilic properties on the removal of 241Am and 239Pu and comparison with parenteral Zn-DTPA was determined. The actinides were administered to adult rats 2 weeks prior to initiation of 30 d of chelation treatment. The TT compounds were given orally while Zn-DTPA was given twice weekly by injection. Total body content of 241Am was measured before and during the treatment period and organ contents of 241Am and 239Pu were measured at the end of the study. Significant reductions in 241Am occurred within the first week, with Zn-DTPA being the most effective. By 3 weeks, the most lipophilic chelator, C22TT was as effective as Zn-DTPA. After 30 d, reductions in organ content of 239Pu and 241Am directly correlated with increasing lipophilicity of the TT chelators. Oral C22TT was as effective as injected Zn-DTPA in liver and bone, the major organs of actinide deposition. The removal of 239Pu from the liver and reduction of redeposition of 239Pu in newly formed bone by C22TT was confirmed by neutron-induced autoradiographs. The amphipathic TT chelators may be useful as orally administered alternatives to current parenteral DTPA for the removal of actinide elements from the body, particularly for longer-term therapeutic applications.


Assuntos
Acetatos/administração & dosagem , Amerício/metabolismo , Ácidos Carboxílicos/administração & dosagem , Quelantes/administração & dosagem , Ácido Pentético/administração & dosagem , Plutônio/metabolismo , Trientina/análogos & derivados , Acetatos/química , Administração Oral , Animais , Medula Óssea/metabolismo , Relação Dose-Resposta a Droga , Fígado/metabolismo , Masculino , Ratos , Ratos Sprague-Dawley , Fatores de Tempo , Distribuição Tecidual , Trientina/administração & dosagem , Trientina/química
16.
Health Phys ; 88(5): 491-6, 2005 May.
Artigo em Inglês | MEDLINE | ID: mdl-15824598

RESUMO

The severity of effect as a function of skeletal radiation dose for induced skeletal malignancy was investigated among a relatively large group of beagle dogs singly injected as young adults with soluble radionuclide. Bone-seeking radionuclides considered were 239Pu, 226Ra, 228Ra, 224Ra, 228Th, and 90Sr. Variables included skeletal radiation dose, tumor growth rate, maximum tumor volume, sex of the animals, growth period of the tumor, degree of calcification of the tumor, skeletal location of the tumor, year of death, and occurrence of metastases. Except for a significant relationship between tumor volume and metastatic process and for growth rate and tumor volume, no significant dependence of any two of these factors could be established. It is concluded from available data on skeletal malignancies among beagles exposed to bone-seeking radionuclides that the severity of the disease is not dependent upon skeletal radiation dose.


Assuntos
Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/etiologia , Relação Dose-Resposta à Radiação , Neoplasias Induzidas por Radiação/diagnóstico , Neoplasias Induzidas por Radiação/etiologia , Radioisótopos/efeitos adversos , Medição de Risco/métodos , Animais , Neoplasias Ósseas/classificação , Cães , Neoplasias Induzidas por Radiação/classificação , Doses de Radiação , Fatores de Risco , Índice de Gravidade de Doença , Análise de Sobrevida
17.
Radiat Res ; 160(5): 517-23, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14565831

RESUMO

Osteosarcomas occur from exposures to bone-seeking, alpha-particle-emitting isotopes, particularly plutonium. The skeletal distribution of putative 239Pu-induced osteosarcomas reported in Mayak Metallurgical and Radiochemical Plutonium Plant workers is compared with those observed in canine studies, and these are compared with distributions of naturally occurring osteosarcomas in both species. In the Mayak workers, 29% and 71% of the osteosarcomas were in the peripheral and central skeleton, respectively, with the spine having the most tumors (36%). An almost identical distribution of plutonium-induced osteosarcomas was reported for dogs injected with 239Pu as young adults. This distribution of osteosarcomas is quite different from the distributions of naturally occurring osteosarcomas for both species. In the Cooperative Osteosarcoma Study Group in humans (1,736 osteosarcomas from all ages), over 91% of the tumors occurred in the peripheral skeleton. In the Mayo Clinic group of older individuals (>40 years old), over 60% of the osteosarcomas appeared in the peripheral skeleton. The distribution of naturally occurring osteosarcomas in the canine is similar to that in the adult human. The similarities of the distributions of plutonium-associated osteosarcomas in the Mayak workers with those found in experimental studies suggest that many of the reported osteosarcomas may have been associated with plutonium exposures. These results also support the experimental paradigm that plutonium osteosarcomas have a preference for well vascularized cancellous bone sites. These sites have a greater initial deposition of plutonium, but also greater turnover due to elevated bone remodeling rates.


Assuntos
Neoplasias Ósseas/classificação , Neoplasias Ósseas/epidemiologia , Neoplasias Induzidas por Radiação/classificação , Neoplasias Induzidas por Radiação/epidemiologia , Osteossarcoma/classificação , Osteossarcoma/epidemiologia , Plutônio/toxicidade , Adolescente , Adulto , Distribuição por Idade , Animais , Cães , Neoplasias Femorais/epidemiologia , Humanos , Incidência , Metalurgia , Pessoa de Meia-Idade , Doenças Profissionais/classificação , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Federação Russa/epidemiologia , Especificidade da Espécie , Neoplasias da Coluna Vertebral/epidemiologia , Análise de Sobrevida
18.
Health Phys ; 86(6): 625-8, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15167126

RESUMO

Neither Fisher's Exact Test nor linear regression analysis (dose-response relationship) using average skeletal dose from 239Pu as a surrogate for marrow dose could establish a statistically significant association between malignant hematopoietic disease (MHD including leukemia and aleukemia) and exposure to 239Pu among dogs in the Utah beagle colony. In addition, when dog-years at risk was the parameter used to estimate the rate of expected malignant hematopoietic tumors in dogs exposed to 239Pu, the estimate was within the range of the 95% confidence limits of the control dogs for six cases (and also within the 95% confidence limits for five cases when the single case of lymphoma was omitted). It was concluded that if there was an effect of 239Pu exposure on the occurrence of MHD in this beagle experiment, it was not very meaningful. These data could not establish a significant susceptibility to neoplasia of either myeloid or lymphoid tissue of 239Pu exposure.


Assuntos
Neoplasias Hematológicas/epidemiologia , Leucemia Induzida por Radiação/epidemiologia , Modelos Biológicos , Plutônio/administração & dosagem , Plutônio/análise , Radiometria/métodos , Medição de Risco/métodos , Distribuição por Idade , Animais , Carga Corporal (Radioterapia) , Modelos Animais de Doenças , Cães , Feminino , Incidência , Injeções , Masculino , Doses de Radiação , Valores de Referência , Análise de Sobrevida , Taxa de Sobrevida
19.
Health Phys ; 86(6): 629-32, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15167127

RESUMO

No significant differences in lifespan could be established between control dogs and dogs given 241Am, 228Th, 90Sr, 228Ra, 226Ra or monomeric 239Pu at low dosage levels that induced less than 10% skeletal malignancies (low dose animals) in the Utah beagle colony when all dogs surviving at least 1 y were included in the analysis and dogs given individual radionuclides were considered separately or together. Censoring or exclusion of dogs from these groups that were diagnosed with skeletal malignancies or that died in a gran mal epileptic seizure made no important difference to these results. Therefore, an enhanced lifespan of low dose dogs as compared with controls could not be established. It is concluded that low doses from internal (mainly skeletal) deposits of these radionuclides probably do not benefit the survival of individuals so exposed.


Assuntos
Neoplasias Ósseas/mortalidade , Longevidade/efeitos da radiação , Modelos Biológicos , Neoplasias Induzidas por Radiação/mortalidade , Radioisótopos/administração & dosagem , Radioisótopos/análise , Radiometria/métodos , Medição de Risco/métodos , Animais , Carga Corporal (Radioterapia) , Modelos Animais de Doenças , Cães , Relação Dose-Resposta à Radiação , Feminino , Injeções , Masculino , Modelos de Riscos Proporcionais , Doses de Radiação , Valores de Referência , Distribuição por Sexo , Análise de Sobrevida , Taxa de Sobrevida
20.
Health Phys ; 84(1): 111-4, 2003 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-12498523

RESUMO

Data in the archives of the beagle project at the University of Utah were used to determine whether there might have been an association between the occurrence of soft tissue cancer and bone tumor (skeletal malignancy) among the dogs injected with bone-seeking radionuclides. In addition to comparing the numbers of animals with and without bone tumors and with and without soft tissue cancers, data on bone sarcomas and soft tissue sarcomas were compared. Longevity (postinjection survival) of the dogs was investigated. It appeared that survival (time between radionuclide injection and death) was important in the eventual expression of malignancies. There could not be established a possible susceptibility to skeletal malignancy associated with the occurrence of soft tissue cancer (or soft tissue sarcoma). We concluded that, although the literature reports an increased susceptibility for subsequent malignancies for individuals with naturally-occurring or radiation-induced cancer, the data derived from this study do not confirm the concept that the appearance of soft tissue cancer is strongly associated with an increased risk of developing a radionuclide-induced skeletal malignancy.


Assuntos
Neoplasias Ósseas/etiologia , Neoplasias Induzidas por Radiação/etiologia , Segunda Neoplasia Primária/etiologia , Radioisótopos , Sarcoma/complicações , Sarcoma/etiologia , Neoplasias de Tecidos Moles/complicações , Animais , Cães , Fatores de Risco , Análise de Sobrevida
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA