Detalhe da pesquisa
1.
A Small Molecule Allele-selective Transcriptional Inhibitor of the MIF Immune Susceptibility Locus.
J Biol Chem
; : 107443, 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38838773
2.
Mapping N- to C-terminal allosteric coupling through disruption of a putative CD74 activation site in D-dopachrome tautomerase.
J Biol Chem
; 299(6): 104729, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37080391
3.
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Mol Med
; 30(1): 43, 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38539088
4.
A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.
J Biol Chem
; 298(12): 102617, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36272649
5.
Insights into Binding of Single-Stranded Viral RNA Template to the Replication-Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations.
Biochemistry
; 61(6): 424-432, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35199520
6.
Structural Insights into Binding of Remdesivir Triphosphate within the Replication-Transcription Complex of SARS-CoV-2.
Biochemistry
; 61(18): 1966-1973, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044776
7.
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM.
J Struct Biol
; 214(4): 107902, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202310
8.
A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J Biol Chem
; 297(3): 101061, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34384784
9.
Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria.
FASEB J
; 35(12): e21997, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34719814
10.
Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir.
Biochemistry
; 60(24): 1869-1875, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110129
11.
A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity.
J Biol Chem
; 294(49): 18522-18531, 2019 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578280
12.
CD74 is a novel transcription regulator.
Proc Natl Acad Sci U S A
; 114(3): 562-567, 2017 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28031488
13.
Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor.
Biochemistry
; 57(26): 3599-3605, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29847104
14.
Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
Angew Chem Int Ed Engl
; 57(24): 7116-7119, 2018 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669180
15.
Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.
J Biol Chem
; 291(30): 15881-95, 2016 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226569
16.
Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail.
Biochem J
; 473(3): 285-96, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26574436
17.
Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties.
J Biol Chem
; 290(16): 10544-54, 2015 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25716316
18.
Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74.
Cytokine
; 88: 62-70, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27573366
19.
MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.
Proc Natl Acad Sci U S A
; 110(27): 10994-9, 2013 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23776208
20.
Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
FASEB J
; 28(11): 4961-71, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25016026