Detalhe da pesquisa
1.
A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology.
Nature
; 591(7850): 431-437, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33505021
2.
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Nat Chem Biol
; 20(5): 646-655, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38347213
3.
Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions.
Neurobiol Dis
; 191: 106411, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38228253
4.
Combining fibril-induced alpha-synuclein aggregation and 6-hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration.
Eur J Neurosci
; 59(1): 132-153, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38072889
5.
Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study.
Eur J Neurosci
; 59(7): 1585-1603, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38356120
6.
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.
J Neuroinflammation
; 21(1): 108, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38664840
7.
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
Acta Neuropathol
; 147(1): 55, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38472475
8.
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.
Nature
; 557(7706): 558-563, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29743672
9.
Positron Emission Tomography with [18F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy.
Int J Mol Sci
; 25(9)2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38732162
10.
A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes.
Neurobiol Dis
; 184: 106196, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37315905
11.
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns.
Brain
; 145(5): 1743-1756, 2022 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910119
12.
Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease.
Brain
; 145(3): 879-886, 2022 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258081
13.
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD.
Proc Natl Acad Sci U S A
; 117(26): 15209-15220, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32541058
14.
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS.
J Neurosci
; 41(9): 2039-2052, 2021 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33472823
15.
Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.
J Biol Chem
; 296: 100273, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33428941
16.
Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread.
Neuropathol Appl Neurobiol
; 48(6): e12829, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727707
17.
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.
Mov Disord
; 37(8): 1739-1748, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35524682
18.
Author Correction: A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology.
Nature
; 592(7855): E10, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33790472
19.
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.
Mol Ther
; 29(9): 2821-2840, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33940158
20.
Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice.
Neurobiol Dis
; 159: 105513, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34536552