Detalhe da pesquisa
1.
Therapeutic potential of coumestan Pks13 inhibitors for tuberculosis.
Antimicrob Agents Chemother
; 95(5)2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558290
2.
Design, Synthesis and Biological Evaluation of N-phenylindole Derivatives as Pks13 Inhibitors againstMycobacterium tuberculosis.
Molecules
; 27(9)2022 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35566191
3.
Effective Host-Directed Therapy for Tuberculosis by Depletion of Myeloid-Derived Suppressor Cells and Related Cells Using a Diphtheria Toxin Fusion Protein.
J Infect Dis
; 224(11): 1962-1972, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955457
4.
Design, synthesis and antimycobacterial evaluation of novel adamantane and adamantanol analogues effective against drug-resistant tuberculosis.
Bioorg Chem
; 106: 104486, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33276981
5.
The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes.
Int Microbiol
; 23(2): 161-170, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-31218537
6.
Revisiting the ß-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.
Antimicrob Agents Chemother
; 63(11)2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31427291
7.
Advancing the Therapeutic Potential of Indoleamides for Tuberculosis.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31010860
8.
Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.
Antimicrob Agents Chemother
; 59(11): 6873-81, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303802
9.
Correction for Mir et al., "Mycobacterial Gene cuvA Is Required for Optimal Nutrient Utilization and Virulence".
Infect Immun
; 87(8)2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31337689
10.
Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence.
Infect Immun
; 82(10): 4104-17, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25047842
11.
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
Antimicrob Agents Chemother
; 57(10): 5138-40, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856770
12.
Risk of tuberculosis reactivation with tofacitinib (CP-690550).
J Infect Dis
; 205(11): 1705-8, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22474037
13.
Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents.
Eur J Med Chem
; 255: 115351, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116266
14.
MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival.
JCI Insight
; 8(20)2023 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37725440
15.
Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice.
mBio
; 14(2): e0349622, 2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36853048
16.
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.
bioRxiv
; 2023 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36865287
17.
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.
Nat Commun
; 14(1): 7427, 2023 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37973991
18.
Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.
J Antimicrob Chemother
; 67(2): 415-21, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22052686
19.
Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment.
J Med Chem
; 65(19): 13240-13252, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36174223
20.
The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.
PLoS Pathog
; 5(7): e1000534, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19649276