1.
Yi Chuan
; 35(7): 896-902, 2013 Jul.
Artigo
em Zh
| MEDLINE
| ID: mdl-23853361
RESUMO
Gonadotrophin-releasing hormone (GnRH) is a key regulator of reproduction in all vertebrates. We first cloned the cDNA and genomic DNA sequences coding for GnRHâ ¡ gene in the orange-spotted grouper (Epinephelis coioides), an economically important marine fish, and then cloned its promoter sequence. The region responsible for the cell-specific expression of GnRHâ ¡ was located between -2005 bp to -956 bp from the translation start site. GnRHâ ¡ promoter driven EGFP expression in transgenic zebrafish showed that GnRHâ ¡-positive neurons were primarily located in the midbrain and in the eyes. Our results provide an improved understanding of the regulatory mechanism and function of GnRHâ ¡ of E. coioides.