Detalhe da pesquisa
1.
HSCVFNT: Inference of Time-Delayed Gene Regulatory Network Based on Complex-Valued Flexible Neural Tree Model.
Int J Mol Sci
; 19(10)2018 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30326663
2.
Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma.
Bioorg Med Chem
; 24(5): 957-66, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819001
3.
Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors.
Int J Mol Sci
; 16(5): 10173-84, 2015 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25950763
4.
Luteolin from Flos Chrysanthemi and its derivatives: New small molecule Bcl-2 protein inhibitors.
Bioorg Med Chem Lett
; 24(19): 4672-4677, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25193233
5.
Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors.
Bioorg Med Chem Lett
; 24(13): 2802-6, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24835199
6.
Synthesis and acrosin inhibitory activities of 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives.
Bioorg Med Chem Lett
; 23(14): 4177-84, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746472
7.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives.
Bioorg Med Chem Lett
; 22(10): 3554-9, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22507960
8.
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
Bioorg Med Chem Lett
; 22(1): 39-44, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22172701
9.
Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.
Arch Pharm (Weinheim)
; 345(6): 454-62, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22415658
10.
N-(2-Hy-droxy-eth-yl)-5-(4-meth-oxy-phen-yl)-4H-pyrazole-3-carboxamide.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 3): o901, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22412749
11.
Ethyl 5-(4-amino-phen-yl)isoxazole-3-carboxyl-ate.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 4): o1111, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22589968
12.
Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.
Bioorg Med Chem Lett
; 21(19): 5822-5, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21880490
13.
Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives.
Bioorg Med Chem Lett
; 21(22): 6674-7, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983437
14.
Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation.
Bioorg Med Chem
; 19(11): 3579-84, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21536450
15.
Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives.
Bioorg Med Chem Lett
; 20(3): 979-82, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20036534
16.
Design and synthesis of novel pyrazino[2,1-a]isoquinolin derivatives with potent antifungal activity.
Arch Pharm (Weinheim)
; 343(6): 360-6, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20232375
17.
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping.
Eur J Med Chem
; 59: 176-82, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23220646
18.
Fragment-based design of novel quinazolinon derivatives as human acrosin inhibitors.
Chem Biol Drug Des
; 81(4): 437-41, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23331539
19.
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.
J Med Chem
; 55(12): 5720-33, 2012 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22676247