RESUMO
We report the observation of a set of coherent high frequency electromagnetic fluctuations that leads to a turbulence induced self-regulating phenomenon in the DIII-D high bootstrap current fraction plasma. The fluctuations have frequency of 130-220 kHz, the poloidal wavelength and phase velocity are 16-30 m^{-1} and â¼30 km/s, respectively, in the outboard midplane with the estimated toroidal mode number nâ¼5-9. The fluctuations are located in the internal transport barrier (ITB) region at large radius and are experimentally validated to be kinetic ballooning modes (KBM). Quasilinear estimation predicts the KBM to be able to drive experimental particle flux and non-negligible thermal flux, suggesting its significant role in regulating the ITB saturation.
RESUMO
Tumor metastasis is the main reason of cancer-related death for gastric cancer (GC) patients and gene expression microarray data indicate that kinesin family member 26B (KIF26B) is one of the most upregulated genes in metastatic GC samples. Specifically, KIF26B expression was upregulated in a stepwise manner from non-tumorous gastric mucosa, primary GC tissues without metastasis, via primary GC tissues with metastasis, to secondary lymph node metastatic (LNM) foci. Increased expression of KIF26B was correlated with tumor size, positive LNM or distant metastases and poor prognosis. KIF26B, negatively regulated by miR-372, promoted GC cell proliferation and metastasis in vitro and in vivo. Mechanistic investigations confirmed that the main target of KIF26B was the vascular endothelial growth factor (VEGF) signaling pathway, particularly by inhibition or overexpression of VEGFA, PXN, FAK, PIK3CA, BCL2 and CREB1. Thus, KIF26B, a novel oncogene regulated by miR-372, promotes proliferation and metastasis through the VEGF pathway in GC.
Assuntos
Metástase Neoplásica/genética , Oncogenes , Neoplasias Gástricas/genética , Fator A de Crescimento do Endotélio Vascular/metabolismo , Animais , Carcinogênese/genética , Linhagem Celular Tumoral , Movimento Celular , Proliferação de Células/genética , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Camundongos , MicroRNAs/metabolismo , Invasividade Neoplásica/genética , Prognóstico , Transdução de Sinais , Regulação para CimaRESUMO
This work contributes to the development of a common framework for the discussion and analysis of dexterous manipulation across the human and robotic domains. An overview of previous work is first provided along with an analysis of the tradeoffs between arm and hand dexterity. A hand-centric and motion-centric manipulation classification is then presented and applied in four different ways. It is first discussed how the taxonomy can be used to identify a manipulation strategy. Then, applications for robot hand analysis and engineering design are explained. Finally, the classification is applied to three activities of daily living (ADLs) to distinguish the patterns of dexterous manipulation involved in each task. The same analysis method could be used to predict problem ADLs for various impairments or to produce a representative benchmark set of ADL tasks. Overall, the classification scheme proposed creates a descriptive framework that can be used to effectively describe hand movements during manipulation in a variety of contexts and might be combined with existing object centric or other taxonomies to provide a complete description of a specific manipulation task.