Detalhe da pesquisa
1.
Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies.
Regul Toxicol Pharmacol
; 119: 104825, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33220389
2.
Classic and evolving approaches to evaluating cross reactivity of mAb and mAb-like molecules - A survey of industry 2008-2019.
Regul Toxicol Pharmacol
; 121: 104872, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33485926
3.
Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics.
Regul Toxicol Pharmacol
; 86: 221-230, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322894
4.
Preclinical safety evaluation of AAV2-sFLT01- a gene therapy for age-related macular degeneration.
Mol Ther
; 19(2): 326-34, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21119620
5.
Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230].
Regul Toxicol Pharmacol
; 88: 364, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431771
6.
Regulatory Consideration for the Nonclinical Safety Assessment of Gene Therapies.
Hum Gene Ther
; 33(21-22): 1126-1141, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35994386
7.
The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases.
Nat Rev Drug Discov
; 23(3): 157-158, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38321319
8.
Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa.
Mol Ther Methods Clin Dev
; 8: 105-120, 2018 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29359172
9.
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets.
Mol Cell Biol
; 22(12): 4280-92, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12024039
10.
Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use.
MAbs
; 9(5): 742-755, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28475417
11.
Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling.
Cancer Biol Ther
; 5(10): 1408-14, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17102589
12.
BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.
Cancer Biol Ther
; 1(2): 177-86, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12170778
13.
Nonclinical evaluation of GMA161--an antihuman CD16 (FcγRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice.
Toxicol Sci
; 125(1): 299-309, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22025730
14.
Marine-derived cancer therapeutics making a splash.
Cancer Biol Ther
; 4(8): 883-4, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103748
15.
Insights into differential endostatin activity.
Cancer Biol Ther
; 3(11): 1167-8, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15640617
16.
Identification of DNA-binding of tumor suppressor genes by chromatin immunoprecipitation.
Methods Mol Biol
; 223: 129-33, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12777725
17.
Analysis of cyclin-dependent kinase activity.
Methods Mol Biol
; 223: 217-20, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12777733
18.
Not reinventing the wheel: applying the 3Rs concepts to viral vector gene therapy biodistribution studies.
Hum Gene Ther Clin Dev
; 24(1): 1-4, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23692377
19.
Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial.
Nat Rev Immunol
; 12(10): 740; author reply 740, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22941443
20.
Apoptotic threshold is lowered by p53 transactivation of caspase-6.
Proc Natl Acad Sci U S A
; 99(14): 9492-7, 2002 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-12089322