Prevalence and Diagnostic Journey of Friedreich's Ataxia in the State of São Paulo, Brazil.

Friedreich's Ataxia (FRDA) is the leading cause of ataxia worldwide, but data on epidemiology and diagnostic journey are scarce, particularly in Latin America. Herein we estimated the prevalence of FRDA in the most populous Brazilian state and characterized the diagnostic odyssey of the disease. We received anonymized data of patients with FRDA from advocacy groups and physicians. Prevalence was estimated dividing the number of patients by the population of the state as reported in the last census. Patients were invited to answer an online survey to describe clinical data and diagnostic journey of the disease. FRDA estimated prevalence was 0.367:100,000, with a slight predominance of women (58.2% vs 41.7%). One hundred and four patients answered the survey (mean age of 37.3 ± 13.8 years; 75.9% classical and 24.0% late onset). On average, 6.2 ± 4.1 physicians were visited before reaching the diagnosis. Mean diagnostic delay was 7.8 ± 6.7 years; no difference between classical and LOFA groups was found. Most of the patients reported unsteadiness and gait abnormalities as the first symptom. Neurologists and orthopedical surgeons were the main specialties first sought by patients. We found a prevalence of 0.36:100,000 for FRDA in the state of São Paulo, Brazil. The disease is characterized by remarkable diagnostic delay, with no relevant differences between classical and LOFA patients.

Identification of separation-related problems in domestic cats: A questionnaire survey.

Identifying and preventing the occurrence of separation-related problems (SRP) in companion animals are relevant to animal welfare and the quality of human-pet interactions. The SRP are defined as a set of behaviors and physiological signs displayed by the animal when separated from its attachment person. In cats, SRP has been insufficiently studied. Thus, the objective of this study was to develop a questionnaire for cat owners which identifies behaviors that may indicate SRP, as well as relates the occurrence of SRP to the management practices applied in the sampled cats. The associations of SRP with cats' characteristics, as well as owner, environmental, and management traits were investigated. The questionnaire was developed based on the scientific literature about separation anxiety syndrome in dogs and a few papers in cats, and it was completed by 130 owners of 223 cats. Analysis of owners' answers was done through categorization and acquisition of relative frequencies of each response category, followed by Fisher's exact test, chi-square tests in contingency table and Multiple Correspondence Analysis. Among the sampled animals, 13.45% (30 / 223) met at least one of the behavioral criteria we used to define SRP. Destructive behavior was the most frequently reported behavior (66.67%, 20 / 30), followed by excessive vocalization (63.33%, 19 / 30), urination in inappropriate places (60.00%, 18 / 30), depression-apathy (53.33%, 16 / 30), aggressiveness (36.67%, 11 / 30) and agitation-anxiety (36.67%, 11 / 30) and, in lower frequency, defecation in inappropriate places (23.33%, 7 / 30). The occurrence of SRP was associated with the number of females living in the residence (P = 0.01), with not having access to toys (P = 0.04), and no other animal residing in the house (P = 0.04). Separation-related problems in domestic cats are difficult to identify due to the limited amount of knowledge regarding the issue. The questionnaire developed in this study supported identification of the main behaviors likely related to SRP in cats and could be used as a starting point for future research.

Temperament in Domestic Cats: A Review of Proximate Mechanisms, Methods of Assessment, Its Effects on Human-Cat Relationships, and One Welfare.

Temperament can be defined as interindividual differences in behavior that are stable over time and in different contexts. The terms 'personality', 'coping styles', and 'behavioral syndromes' have also been used to describe these interindividual differences. In this review, the main aspects of cat temperament research are summarized and discussed, based on 43 original research papers published between 1986 and 2020. We aimed to present current advances in cat temperament research and identify potential gaps in knowledge, as well as opportunities for future research. Proximate mechanisms, such as genetic bases of temperament, ontogenesis and developmental factors, physiological mechanisms, and relationships with morphology, were reviewed. Methods traditionally used to assess the temperament of cats might be classified based on the duration of procedures (short- vs. long-term measures) and the nature of data recordings (coding vs. rating methods). The structure of cat temperament is frequently described using a set of behavioral dimensions, primarily based on interindividual variations in cats' responses toward humans and conspecifics (e.g., friendliness, sociability, boldness, and aggressiveness). Finally, cats' temperaments have implications for human-animal interactions and the one welfare concept. Temperament assessment can also contribute to practical aspects, for example, the adoption of shelter cats.

Beloved Whiskers: Management Type, Care Practices and Connections to Welfare in Domestic Cats.

The quality of cat care practices depends in part on the type of management applied, which either positively or negatively impacts cat welfare. This study investigated whether the type of cat management (indoor vs. outdoor) was related to other cat care practices adopted by cat owners, associated with the quality of human-cat relationships and cat welfare. An online survey was distributed via social networks. Descriptive statistics, categorical Principal Component Analysis, Fisher's Exact test and Chi-square test in contingency table were applied. A total of 16,302 cat owners returned the survey. Most Brazilian owners reported indoor management of their cats; this was related to owners living in apartments, more frequent use of cat care practices, and more interactions with their pets. Outdoor management was related to cats living in houses or farms, sleeping outdoors or around the neighborhood, and owners had fewer interaction with their pets. In conclusion, owners practicing indoor management seemed to be closer to their cats than owners reporting outdoor management. However, obesity and owner-reported behavioral problems were associated with indoor management.

Percepção dos alunos do ensino médio em relação a uma proposta de ensino das lutas nas aulas de Educação Física / Perception of high school students in relation to a proposal for teaching martial arts in Physical Education classes / Percepción de estudiantes de secundaria en relación a una propuesta de enseñanza de lucha en las clases de Educación Física

O objetivo do estudo foi analisar a percepção dos alunos do Ensino Médio em relação às lutas enquanto unidade temática nas aulas de Educação Física. Para tanto, a pesquisa se caracterizou como de natureza aplicada, do tipo descritiva, com a participação de 17 alunos do Ensino Médio. A pesquisa foi realizada em dois momentos, sendo o pri-meiro referente ao desenvolvimento de uma intervenção pedagógica do conteúdo de lutas, e o segundo a partir da aplicação de um questionário. Os resultados apontaram que 82% dos participantes usufruíram de uma prática positiva e prazerosa e 94% dos participantes afirmaram ausência de violência. Assim, compreende-se que as lutas na escola se configuram como um mediador na transformação das apreciações de concepções pelos participantes.

The aim of the study was to analyze the perception of high school students in relation to martial arts as a content in Physical Education classes. Therefore, the research was characterized as being of an applied nature, of the descriptive type, with the participation of 17 high school students. The research was carried out in two moments, the first one referring to the development of a pedagogical intervention on the content of martial arts, and the second one based on the application of a questionnaire. The results showed that 82% of the participants en-joyed a positive and pleasant practice and 94% of the participants stated that there was no violence in the classes. Thus, it is understood that the development of martial arts at school was configured as a mediator in the transformation of the appreciation of conceptions by the participants.

El objetivo del estudio fue analizar la percepción de los estu-diantes de secundaria en relación a las peleas como unidad temática en las clases de Educación Física. Por lo tanto, la investigación se caracterizó por ser de carácter aplicada, de tipo descriptiva, con la participación de 17 estudiantes de secundaria. La investigación se realizó en dos momen-tos, el primero referido al desarrollo de una intervención pedagógica so-bre el contenido de las peleas, y el segundo a partir de la aplicación de un cuestionario. Los resultados mostraron que el 82% de los participantes disfrutaron de una práctica positiva y agradable y el 94% de los participantes afirmó que no hubo violencia en las clases. Así, se entiende que el desarrollo de las luchas en la escuela se configuró como un mediador en la transformación de la apreciación de las concepciones por parte de los participantes.

Percepção dos alunos do ensino médio em relação a uma proposta de ensino das lutas nas aulas de Educação Física / Perception of high school students in relation to a proposal for teaching martial arts in Physical Education classes / Percepción de estudiantes de secundaria en relación a una propuesta de enseñanza de lucha en las clases de Educación Física

O objetivo do estudo foi analisar a percepção dos alunos do Ensino Médio em relação às lutas enquanto unidade temática nas aulas de Educação Física. Para tanto, a pesquisa se caracterizou como de natureza aplicada, do tipo descritiva, com a participação de 17 alunos do Ensino Médio. A pesquisa foi realizada em dois momentos, sendo o primeiro referente ao desenvolvimento de uma intervenção pedagógica do conteúdo de lutas, e o segundo a partir da aplicação de um questionário. Os resultados apontaram que 82% dos participantes usufruíram de uma prática positiva e prazerosa e 94% dos participantes afirmaram ausência de violência. Assim, compreende-se que as lutas na escola se configuram como um mediador na transformação das apreciações de concepções pelos participantes (AU).

The aim of the study was to analyze the perception of high school students in relation to martial arts as a content in Physical Education classes. Therefore, the research was characterized as being of an applied nature, of the descriptive type, with the participation of 17 high school students. The research was carried out in two moments, the first one referring to the development of a pedagogical intervention on the content of martial arts, and the second one based on the application of a questionnaire. The results showed that 82% of the participants en-joyed a positive and pleasant practice and 94% of the participants stated that there was no violence in the classes. Thus, it is understood that the development of martial arts at school was configured as a mediator in the transformation of the appreciation of conceptions by the participants (AU).

El objetivo del estudio fue analizar la percepción de los estu-diantes de secundaria en relación a las peleas como unidad temática en las clases de Educación Física. Por lo tanto, la investigación se caracterizó por ser de carácter aplicada, de tipo descriptiva, con la participación de 17 estudiantes de secundaria. La investigación se realizó en dos momen-tos, el primero referido al desarrollo de una intervención pedagógica so-bre el contenido de las peleas, y el segundo a partir de la aplicación de un cuestionario. Los resultados mostraron que el 82% de los participantes disfrutaron de una práctica positiva y agradable y el 94% de los pantes afirmó que no hubo violencia en las clases. Así, se entiende que el desarrollo de las luchas en la escuela se configuró como un mediador en la transformación de la apreciación de las concepciones por parte de los participantes (AU).

A formação acadêmica em educação física para a atenção básica do SUS: uma revisão integrativa em teses e dissertações / Academic training in physical education for primary care in the SUS: an integrative review of theses and dissertations / La formación académica en educación física para la atención primaria en el SUS: una revisión integradora de tesis y disertaciones

Faz-se necessário abordar criticamente a promoção da saúde e os elementos que impactam o processo saúde/doença no cotidiano da formação do professor de Educação Física (EF). Portanto, este estu-do tem como objetivo analisar teses e dissertações produzidas sobre a formação acadêmica em EF e sua relação com a saúde no contexto do Sistema Único de Saúde (SUS), por meio de uma revisão integrati-va. O estudo encontrou seis dissertações que mostraram que apesar da percepção das universidades de que a formação acadêmica permite aos professores de EF atuar no SUS, é possível identificar a manutenção do discurso conservador e biomédico, o que afeta a compreensão, a per-cepção e a ação dos professores de EF em equipes multiprofissionais no contexto da Saúde Coletiva presente no SUS

It is necessary to critically approach health promotion and the elements that impact the health/disease process in the daily training of Physical Education (PE) teachers. Therefore, this study aims to analyze the theses and dissertations produced on academic training in PE and its relationship with health in the context of the Unified Health System (SUS), through an integrative review. The study found six dissertations that showed that, despite the universities' perception that academic training allows PE teachers to work in the SUS, it is possible to identify the maintenance of the conservative and biomedical discourse, which affects understanding, perception and action of PE teachers in multidis-ciplinary teams in the context of Collective Health in the present SUS.

Es necesario abordar críticamente la promoción de la salud y los elementos que impactan el proceso salud/enfermedad en la formación diaria de los docentes de Educación Física (EF). Por lo tanto, este estudio tiene como objetivo analizar tesis y disertaciones producidas sobre la formación académica en EF y su relación con la salud en el contexto del Sistema Único de Salud (SUS), a través de una revisión integradora. El estudio encontró seis disertaciones que demostraron que, a pesar de la percepción de las universidades de que la formación académica permite que los profesores de EF actúen en el SUS, es posible identificar el mantenimiento del discurso conservador y biomédico, que afecta la comprensión, la percepción y la acción de los profesores de EF en equipos multidisciplinarios en el contexto de la Salud Colectiva en el SUS actual.

A formação acadêmica em educação física para a atenção básica do SUS: uma revisão integrativa em teses e dissertações / Academic training in physical education for primary care in the SUS: an integrative review of theses and dissertations / La formación académica en educación física para la atención primaria en el SUS: una revisión integradora de tesis y disertaciones

Faz-se necessário abordar criticamente a promoção da saúde e os elementos que impactam o processo saúde/doença no cotidiano da formação do professor de Educação Física (EF). Portanto, este estudo tem como objetivo analisar teses e dissertações produzidas sobre a formação acadêmica em EF e sua relação com a saúde no contexto do Sistema Único de Saúde (SUS), por meio de uma revisão integrativa. O estudo encontrou seis dissertações que mostraram que apesar da percepção das universidades de que a formação acadêmica permite aos professores de EF atuar no SUS, é possível identificar a manutenção do discurso conservador e biomédico, o que afeta a compreensão, a percepção e a ação dos professores de EF em equipes multiprofissionais no contexto da Saúde Coletiva presente no SUS (AU).

It is necessary to critically approach health promotion and the elements that impact the health/disease process in the daily training of Physical Education (PE) teachers. Therefore, this study aims to analyze the theses and dissertations produced on academic training in PE and its relationship with health in the context of the Unified Health System (SUS), through an integrative review. The study found six dissertations that showed that, despite the universities' perception that academic training allows PE teachers to work in the SUS, it is possible to identify the maintenance of the conservative and biomedical discourse, which affects understanding, perception and action of PE teachers in multidis-ciplinary teams in the context of Collective Health in the present SUS (AU)

Es necesario abordar críticamente la promoción de la salud y los elementos que impactan el proceso salud/enfermedad en la formación diaria de los docentes de Educación Física (EF). Por lo tanto, este estudio tiene como objetivo analizar tesis y disertaciones producidas sobre la formación académica en EF y su relación con la salud en el contexto del Sistema Único de Salud (SUS), a través de una revisión integradora. El estudio encontró seis disertaciones que demostraron que, a pesar de la percepción de las universidades de que la formación académica permite que los profesores de EF actúen en el SUS, es posible identificar el mantenimiento del discurso conservador y biomédico, que afecta la comprensión, la percepción y la acción de los profesores de EF en equipos multidisciplinarios en el contexto de la Salud Colectiva en el SUS actual

Eicosapentaenoic acid (EPA) vs. Docosahexaenoic acid (DHA): Effects in epididymal white adipose tissue of mice fed a high-fructose diet.

BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated to be beneficial for many diseases, including those associated with the metabolic syndrome (e.g. insulin resistance and hypertension). Nevertheless, not only their actions are not entirely understood, but also their only effects were not yet elucidated. Therefore, we aimed to compare the effects of EPA and DHA, alone or in combination, on the epididymal white adipose tissue (WAT) metabolism in mice fed a high-fructose diet. METHODS: 3-mo-old C57Bl/6 mice were fed a control diet (C) or a high-fructose diet (HFru). After three weeks on the diets, the HFru group was subdivided into four new groups for another five weeks: HFru, HFru+EPA, HFru+DHA, and HFru-EPA+DHA (n=10/group). Besides evaluating biometric and metabolic parameters of the animals, we measured the adipocyte area and performed molecular analyses (inflammation and lipolysis) in the epididymal WAT. RESULTS: The HFru group showed adipocyte hypertrophy, inflammation, and uncontrolled lipolysis. The treated animals showed a reversion of adipocyte hypertrophy, inhibition of inflammation with activation of anti-inflammatory mediators, and regularization of lipolysis. Overall, the beneficial effects were more marked with DHA than EPA. CONCLUSION: Although the whole-body metabolic effects were similar between EPA and DHA, DHA appeared to be the central actor in WAT metabolism, modulating pro and anti-inflammatory pathways and alleviating adipocytes abnormalities. Therefore, when considering fructose-induced adverse effects in WAT, the most prominent actions were observed with DHA.