Detalhe da pesquisa
1.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
PLoS Biol
; 22(4): e3002259, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683873
2.
Targeting ROS production through inhibition of NADPH oxidases.
Nat Chem Biol
; 19(12): 1540-1550, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884805
3.
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer.
Cancer Cell Int
; 24(1): 56, 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38317193
4.
Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors.
EMBO Rep
; 23(6): e54721, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35383427
5.
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription.
Nucleic Acids Res
; 50(5): 2566-2586, 2022 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35150567
6.
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity.
Antimicrob Agents Chemother
; 67(11): e0066123, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37850734
7.
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells.
J Enzyme Inhib Med Chem
; 38(1): 2163242, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36629431
8.
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII.
J Enzyme Inhib Med Chem
; 38(1): 2188147, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36912265
9.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Gastroenterology
; 161(5): 1584-1600, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245764
10.
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity.
J Enzyme Inhib Med Chem
; 37(1): 973-985, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35317680
11.
Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies.
Int J Mol Sci
; 23(7)2022 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35409409
12.
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy.
Int J Mol Sci
; 23(4)2022 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216371
13.
Current HDAC Inhibitors in Clinical Trials.
Chimia (Aarau)
; 76(5): 448-453, 2022 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069716
14.
Histone-deacetylase 8 drives the immune response and the growth of glioma.
Glia
; 69(11): 2682-2698, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34310727
15.
Anti-influenza A virus activity and structure-activity relationship of a series of nitrobenzoxadiazole derivatives.
J Enzyme Inhib Med Chem
; 36(1): 2128-2138, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34583607
16.
Epigenetic polypharmacology: A new frontier for epi-drug discovery.
Med Res Rev
; 40(1): 190-244, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31218726
17.
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene.
Hum Genet
; 139(2): 227-245, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31919630
18.
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes.
Int J Mol Sci
; 21(10)2020 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32455951
19.
Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells.
Molecules
; 25(14)2020 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32650558
20.
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.
Int J Mol Sci
; 20(22)2019 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31726691