Detalhe da pesquisa
1.
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Nature
; 594(7863): 418-423, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33953400
2.
Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis.
Mol Cell
; 76(6): 853-855, 2019 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31951530
3.
The RAS/MAPK Axis Gets Stressed Out.
Mol Cell
; 64(5): 854-855, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27912095
4.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35065235
5.
Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation.
Biochemistry
; 59(41): 3982-3992, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32970425
6.
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Nature
; 501(7466): 232-6, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23934108
7.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479743
8.
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Bioorg Med Chem Lett
; 26(2): 534-539, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26639762
9.
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Nature
; 464(7287): 431-5, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20130576
10.
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 25(1): 75-82, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466195
11.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc Natl Acad Sci U S A
; 109(14): 5299-304, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431598
12.
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.
Bioorg Med Chem Lett
; 24(24): 5704-5709, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453805
13.
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(24): 5683-5687, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25467161
14.
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(16): 3764-71, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25037916
15.
A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors.
Bioorg Med Chem Lett
; 23(18): 5097-104, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23932790
16.
Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 23(20): 5533-9, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012183
17.
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 23(11): 3186-94, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23628333
18.
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation.
Cell Chem Biol
; 2023 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36773603
19.
Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.
Bioorg Med Chem Lett
; 22(17): 5396-404, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22877636
20.
Identifying transcriptional programs underlying cancer drug response with TraCe-seq.
Nat Biotechnol
; 40(1): 86-93, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531539