Detalhe da pesquisa
1.
Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy.
N Engl J Med
; 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38739079
2.
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.
N Engl J Med
; 384(2): 105-116, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33185990
3.
Cardiac Troponin and Treatment Effects of Omecamtiv Mecarbil: Results From the GALACTIC-HF Study.
J Card Fail
; 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38215932
4.
The Effect of Omecamtiv Mecarbil in Hospitalized Patients as Compared With Outpatients With HFrEF: An Analysis of GALACTIC-HF.
J Card Fail
; 30(1): 26-35, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37683911
5.
Efficacy and Safety of Aficamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Results From the REDWOOD-HCM Trial, Cohort 4.
J Card Fail
; 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38493832
6.
Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.
Hum Mol Genet
; 30(14): 1305-1320, 2021 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33909041
7.
Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial.
Eur Heart J
; 43(23): 2212-2220, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35325102
8.
Effects of omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: the GALACTIC-HF trial.
Eur Heart J
; 43(48): 5006-5016, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675469
9.
Pharmacokinetics of a single dose of Aficamten (CK-274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model.
J Vet Pharmacol Ther
; 46(1): 52-61, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36382714
10.
Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial.
JAMA
; 328(3): 259-269, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35852527
11.
Fast skeletal muscle troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction.
J Physiol
; 597(17): 4615-4625, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31246276
12.
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc Natl Acad Sci U S A
; 113(47): E7448-E7455, 2016 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815532
13.
Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator tirasemtiv.
Int J Mol Sci
; 20(20)2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31658633
14.
Aficamten for Drug-Refractory Severe Obstructive Hypertrophic Cardiomyopathy in Patients Receiving Disopyramide: REDWOOD-HCM Cohort 3.
J Card Fail
; 29(11): 1576-1582, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37473912
15.
CK-2127107 amplifies skeletal muscle response to nerve activation in humans.
Muscle Nerve
; 57(5): 729-734, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29150952
16.
The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle.
J Physiol
; 595(5): 1657-1670, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27869319
17.
Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial.
Lancet
; 388(10062): 2895-2903, 2016 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914656
18.
Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.
Cardiovasc Drugs Ther
; 31(4): 445-458, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28735360
19.
Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol
; 311(1): L20-8, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27190061
20.
Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program.
Health Qual Life Outcomes
; 14(1): 131, 2016 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27629389