Detalhe da pesquisa
1.
Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and ß2-adrenoceptor agonist properties.
J Pharmacol Exp Ther
; 351(1): 190-9, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25100753
2.
Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and ß(2)-adrenoceptor agonist (MABA).
Pulm Pharmacol Ther
; 25(5): 357-63, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22766316
3.
THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner.
Mol Pharmacol
; 79(3): 389-99, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21139051
4.
Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.
Bioorg Med Chem Lett
; 21(5): 1354-8, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21310610
5.
Specificity of induction of the vanA and vanB operons in vancomycin-resistant enterococci by telavancin.
Antimicrob Agents Chemother
; 54(7): 2814-8, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20404117
6.
Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II.
Antimicrob Agents Chemother
; 53(8): 3375-83, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19470513
7.
Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.
Pharmacol Res Perspect
; 6(3): e00400, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29736245
8.
Health Product Manufacturers and Innovators COVID-19 Impact Assessment: Lessons Learned and Compelling Needs.
NAM Perspect
; 20222022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35402857
9.
Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and ß2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
J Med Chem
; 58(6): 2609-22, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25629394
10.
Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies.
Curr Opin Investig Drugs
; 5(1): 40-9, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14983972
11.
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.
Angew Chem Int Ed Engl
; 37(20): 2754-2794, 1998 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711117
12.
Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation.
Naunyn Schmiedebergs Arch Pharmacol
; 384(6): 555-63, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21947231
13.
Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist.
Eur J Pharmacol
; 605(1-3): 145-52, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168050
14.
A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor.
Mol Pharmacol
; 72(2): 291-302, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17478612