Detalhe da pesquisa
1.
Practical syntheses of DOTAGA-DBCO and DFO-DBCO, strained alkyne pre-cursors to radioimmunoconjugates for targeted alpha therapy.
Bioorg Med Chem
; 73: 117010, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126444
2.
Oxysterols direct B-cell migration through EBI2.
Nature
; 475(7357): 519-23, 2011 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21796211
3.
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Proc Natl Acad Sci U S A
; 111(33): 12163-8, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092323
4.
Regioselective Electrophilic Fluorination of Rationally Designed Imidazole Derivatives.
J Org Chem
; 81(3): 1269-76, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26741948
5.
Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.
Bioorg Med Chem Lett
; 26(20): 4888-4891, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27658369
6.
Allyl-Assisted, Cu(I)-Catalyzed Azide-Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure.
J Org Chem
; 80(21): 11003-12, 2015 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26458051
7.
A step-economical route to fused 1,2,3-triazoles via an intramolecular 1,3-dipolar cycloaddition between a nitrile and an in situ generated aryldiazomethane.
J Org Chem
; 79(18): 8889-94, 2014 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25158214
8.
Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.
Mol Pharmacol
; 82(6): 1094-103, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22930711
9.
Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3.
J Org Chem
; 76(20): 8262-9, 2011 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21899258
10.
Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist.
Org Biomol Chem
; 9(8): 2654-60, 2011 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21365101
11.
Practical synthesis of a Cathepsin S inhibitor: route identification, purification strategies, and serendipitous discovery of a crystalline salt form.
J Org Chem
; 75(6): 1940-7, 2010 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20155974
12.
Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup.
J Org Chem
; 75(13): 4463-71, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20536151
13.
Practical and scalable synthesis of a selective CCK1 receptor antagonist.
J Org Chem
; 75(22): 7950-3, 2010 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20977279
14.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Bioorg Med Chem Lett
; 20(7): 2370-4, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153648
15.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
ACS Med Chem Lett
; 11(10): 2002-2009, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062185
16.
An efficient intramolecular 1,3-dipolar cycloaddition involving 2-(1,2-dichlorovinyloxy)aryldiazomethanes: a one-pot synthesis of benzofuropyrazoles from salicylaldehydes.
J Org Chem
; 74(2): 891-4, 2009 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19053198
17.
CuI-catalyzed amination of arylhalides with guanidines or amidines: a facile synthesis of 1-H-2-substituted benzimidazoles.
J Org Chem
; 74(15): 5742-5, 2009 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19527012
18.
Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: a novel synthesis of 1,3,4-trisubstituted pyrazoles.
Org Lett
; 10(6): 1307-10, 2008 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18302402
19.
Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: application of the Shapiro reaction and alkenylsilane cross-coupling.
Org Lett
; 9(8): 1505-8, 2007 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17362023
20.
Gram-Scale Synthesis of a ß-Secretase 1 (BACE 1) Inhibitor.
ACS Omega
; 2(2): 397-408, 2017 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30023606