1.
Org Biomol Chem
; 17(35): 8067-8070, 2019 09 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31451812
RESUMO
Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramolecular oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by our methodology. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.