Detalhe da pesquisa
1.
Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability.
Int J Mol Sci
; 25(1)2023 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38203326
2.
Potential of Vitamin B6 Dioxime Analogues to Act as Cholinesterase Ligands.
Int J Mol Sci
; 23(21)2022 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36362178
3.
Activation of (un)regulated cell death as a new perspective for bispyridinium and imidazolium oximes.
Arch Toxicol
; 95(8): 2737-2754, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34173857
4.
Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases.
Biochem J
; 477(15): 2771-2790, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32639532
5.
Zebrafish (Danio rerio) Oatp2b1 as a functional ortholog of the human OATP2B1 transporter.
Fish Physiol Biochem
; 47(6): 1837-1849, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34546486
6.
Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases.
Int J Mol Sci
; 21(21)2020 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33138280
7.
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.
Chemistry
; 24(38): 9675-9691, 2018 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672968
8.
The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry.
Acta Chim Slov
; 64(1): 15-39, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28380234
9.
Investigation of Paraoxonase-1 Genotype and Enzyme-Kinetic Parameters in the Context of Cognitive Impairment in Parkinson's Disease.
Antioxidants (Basel)
; 12(2)2023 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36829958
10.
Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease.
Chem Biol Interact
; 382: 110620, 2023 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37406982
11.
Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells.
Toxicology
; 494: 153588, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37419273
12.
Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.
Pharmaceuticals (Basel)
; 15(10)2022 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36297332
13.
4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer's Disease.
Pharmaceutics
; 14(6)2022 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35745878
14.
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.
Eur J Med Chem
; 238: 114377, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35526478
15.
Selective interaction of microcystin congeners with zebrafish (Danio rerio) Oatp1d1 transporter.
Chemosphere
; 283: 131155, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34182632
16.
Interaction of organotin compounds with three major glutathione S-transferases in zebrafish.
Toxicol In Vitro
; 62: 104713, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31706034
17.
Molecular characterization of zebrafish Gstr1, the only member of teleost-specific glutathione S- transferase class.
Aquat Toxicol
; 208: 196-207, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30682622
18.
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.
J Med Chem
; 61(23): 10753-10766, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30383374
19.
Interaction between the zebrafish (Danio rerio) organic cation transporter 1 (Oct1) and endo- and xenobiotics.
Aquat Toxicol
; 187: 18-28, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363126
20.
Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases.
Chem Biol Interact
; 259(Pt B): 122-132, 2016 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27238725