Prognosis of Indirect Composite Resin Cuspal Coverage on Endodontically Treated Premolars and Molars: An In Vivo Prospective Study.

PURPOSE: This prospective clinical study evaluated the success rate of indirect composite resin cuspal coverage on endodontically treated molars and premolars and the survival rate of the restored teeth. MATERIALS AND METHODS: One hundred fifty endodontically treated teeth were restored with total resin cuspal coverage and randomly selected for the study. Patients were recalled after 2 to 5 years for clinical evaluation. Data were subjected to standard tests of statistical correlations using Spearman test. RESULTS: Out of the 150 teeth, 84 were molars and 66 were premolars. Of these teeth, 58.7% had mesio-occlusal-distal (MOD) cavities, 20.7% had mesio-occlusal (MO), and 20.7% had occlusal-distal (OD). A build-up procedure was performed in 51.3% of the teeth, and buccal veneer composite resins were placed at the margins of 96.7% of the teeth. Out of the 150 teeth, 30 (20%) presented margin discoloration, 3 teeth (2%) had restoration reparable fractures, 2 teeth (1.3%) had restoration irreparable fractures, and 1 tooth (0.7%) exhibited secondary recurrent caries. The opposing arch that occluded with the treated teeth presented 58% natural teeth (no restoration material), 26.7% ceramic crowns, and 15.3% implant-supported ceramic crowns. Statistically significant differences (p = 0.018) between irreparable restoration fractures and the type of support material present in the opposing arch were found. CONCLUSIONS: In a period of up to 5 years, the resin cuspal coverage of endodontic treated teeth had a success rate of 96%, while the tooth survival rate was 100%. The type of support material on the opposing arch may influence the longevity of the restoration of endodontically treated teeth.

Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators.

Fe-S cluster biogenesis machinery is required for multiple DNA metabolism processes. In this work, we show that, in Saccharomyces cerevisiae, defects at different stages of the mitochondrial Fe-S cluster assembly machinery (ISC) result in increased spontaneous mutation rate and hyper-recombination, accompanied by an increment in Rad52-associated DNA repair foci and a higher phosphorylated state of γH2A histone, altogether supporting the presence of constitutive DNA lesions. Furthermore, ISC assembly machinery deficiency elicits a DNA damage response that upregulates ribonucleotide reductase activity by promoting the reduction of Sml1 levels and the cytosolic redistribution of Rnr2 and Rnr4 enzyme subunits. Depending on the impaired stage of the ISC machinery, different signaling pathway mediators contribute to such a response, converging on Dun1. Thus, cells lacking the glutaredoxin Grx5, which are compromised at the core ISC system, show Mec1- and Rad53-independent Dun1 activation, whereas both Mec1 and Chk1 are required when the non-core ISC member Iba57 is absent. Grx5-null cells exhibit a strong dependence on the error-free post-replication repair and the homologous recombination pathways, demonstrating that a DNA damage response needs to be activated upon ISC impairment to preserve cell viability.

Arabidopsis glutaredoxin S17 and its partner, the nuclear factor Y subunit C11/negative cofactor 2α, contribute to maintenance of the shoot apical meristem under long-day photoperiod.

Glutaredoxins (GRXs) catalyze the reduction of protein disulfide bonds using glutathione as a reductant. Certain GRXs are able to transfer iron-sulfur clusters to other proteins. To investigate the function of Arabidopsis (Arabidopsis thaliana) GRXS17, we applied a strategy combining biochemical, genetic, and physiological approaches. GRXS17 was localized in the nucleus and cytosol, and its expression was elevated in the shoot meristems and reproductive tissues. Recombinant GRXS17 bound Fe2S2 clusters, a property likely contributing to its ability to complement the defects of a Baker's yeast (Saccharomyces cerevisiae) strain lacking the mitochondrial GRX5. However, a grxs17 knockout Arabidopsis mutant exhibited only a minor decrease in the activities of iron-sulfur enzymes, suggesting that its primary function is as a disulfide oxidoreductase. The grxS17 plants were sensitive to high temperatures and long-day photoperiods, resulting in elongated leaves, compromised shoot apical meristem, and delayed bolting. Both environmental conditions applied simultaneously led to a growth arrest. Using affinity chromatography and split-Yellow Fluorescent Protein methods, a nuclear transcriptional regulator, the Nuclear Factor Y Subunit C11/Negative Cofactor 2α (NF-YC11/NC2α), was identified as a GRXS17 interacting partner. A mutant deficient in NF-YC11/NC2α exhibited similar phenotypes to grxs17 in response to photoperiod. Therefore, we propose that GRXS17 interacts with NF-YC11/NC2α to relay a redox signal generated by the photoperiod to maintain meristem function.

An association between temporomandibular disorder and gum chewing.

This single center, randomized, small study sought to investigate the prevalence and frequency of chewing gum consumption, and whether there is a relationship between these factors and the presence of symptoms associated with temporomandibular disorder (TMD). Subjects were divided into 7 groups based on their parafunctional oral habits. Of these, subjects who chewed gum were divided into 5 subgroups (A-E) based on their gum chewing habits. Group A chewed gum <1 hour/day (n = 12), Group B chewed gum 1-2 hours/day (n = 11), Group C chewed gum 3 hours/day (n = 6), and Group D chewed gum >3 hours at a time (n = 8); the frequency of gum chewing in Groups A-D was once a week. Group E subjects chewed gum 1-3 times/week for at least 1 hour each occurrence (n = 2). Sixty-three percent of the subjects in Group D reported TMD symptoms of arthralgia and myofascial pain. Thirty-three percent of the subjects in Group C showed symptoms of arthralgia. Eighty-three percent of the subjects in Group A and 27% in Group B reported myofascial pain. All subjects in Group E reported masseter hypertrophy. The remaining 2 groups were Group F, subjects that didn't chew gum but had other parafunctional oral habits (n = 2), and Group G, subjects who didn't have parafunctional oral habits (n = 12).

Deep learning pose detection model for sow locomotion.

Lameness affects animal mobility, causing pain and discomfort. Lameness in early stages often goes undetected due to a lack of observation, precision, and reliability. Automated and non-invasive systems offer precision and detection ease and may improve animal welfare. This study was conducted to create a repository of images and videos of sows with different locomotion scores. Our goal is to develop a computer vision model for automatically identifying specific points on the sow's body. The automatic identification and ability to track specific body areas, will allow us to conduct kinematic studies with the aim of facilitating the detection of lameness using deep learning. The video database was collected on a pig farm with a scenario built to allow filming of sows in locomotion with different lameness scores. Two stereo cameras were used to record 2D videos images. Thirteen locomotion experts assessed the videos using the Locomotion Score System developed by Zinpro Corporation. From this annotated repository, computational models were trained and tested using the open-source deep learning-based animal pose tracking framework SLEAP (Social LEAP Estimates Animal Poses). The top-performing models were constructed using the LEAP architecture to accurately track 6 (lateral view) and 10 (dorsal view) skeleton keypoints. The architecture achieved average precisions values of 0.90 and 0.72, average distances of 6.83 and 11.37 in pixel, and similarities of 0.94 and 0.86 for the lateral and dorsal views, respectively. These computational models are proposed as a Precision Livestock Farming tool and method for identifying and estimating postures in pigs automatically and objectively. The 2D video image repository with different pig locomotion scores can be used as a tool for teaching and research. Based on our skeleton keypoint classification results, an automatic system could be developed. This could contribute to the objective assessment of locomotion scores in sows, improving their welfare.

Prevalence of bruxism in adults with cerebral palsy institutionalized in Lisbon.

OBJECTIVE: To determine the prevalence of bruxism in individuals with cerebral palsy (CP) and evaluating the various factors associated METHODS: One hundred and ten adults diagnosed with CP were selected from six institutions for people with special needs. Data were collected through oral examinations using the diagnostic criteria proposed by the American Academy of Sleep Medicine and the modified scale of Asworth RESULTS: Of the total sample, spastic tetraplegia was the most common type and half of the population presents severe intellectual disability. The prevalence of bruxism was 74,5%. Wear facets were observed in 67.9% of the sample, 59.1% of which were brilliant. There was a positive association between mixed bruxism (MB) and the spasticity classification. Through a logistic regression it was found that the risk of having MB and general bruxism (GB) is greater in individuals who have shiny wear facets. CONCLUSIONS: In the present study the high prevalence of GB indicates there is an urgent need for treatment options in people with CP. More studies are needed with standardized diagnostic protocols and representative samples to evaluate the factors that influence the presence of bruxism in this population and to establish an appropriate treatment planning.

Management of periapical lesion with persistent exsudate.

This case describes the treatment and follow-up of a mandibular molar in an 18-year-old female with a periapical cyst. Thus, it becomes important to know which options should we take when faced with a clinical situation that we cannot resolve through conventional methods, and which techniques and approaches we have to achieve treatment success. This case showed the treatment plan and follow-up, by the use of CBCT images, from a previously treated mandibular molar with a large periapical abscess and cystic lesion, in which, the first treatment plan approach was to make the endodontic retreatment. During the chemo-mechanical preparation the presence of permanent intracanal purulent exudate made it impossible to dry the canals, impeding obturation of the root canal system. Due to this clinical situation, a surgical approach was performed with the intention of reduce this permanent exudate and to execute a decompression technique. Clinical findings, periapical radiographs and cone beam computed tomographic, indicated almost complete resolution of the radiolucency, after a one-year follow-up.

Este relato de caso descreve o tratamento e acompanhamento de um molar inferior em uma jovem de 18 anos com cisto periapical. Assim, torna-se importante saber quais opções devemos tomar diante de uma situação clínica que não podemos resolver pelos métodos convencionais, e quais técnicas e abordagens temos para alcançar o sucesso do tratamento. Este caso mostrou o plano de tratamento e acompanhamento, por meio de imagens de tomografia computadorizada de feixe cônico (TCFC), de um molar inferior previamente tratado com grande abscesso periapical e lesão cística, no qual, a primeira abordagem do plano de tratamento foi fazer o retratamento endodôntico. Durante o preparo químico-mecânico a presença de exsudato purulento intracanal permanente impossibilitou a secagem dos canais, impedindo a obturação do sistema de canais radiculares. Devido a essa situação clínica, foi realizada abordagem cirúrgica com a intenção de reduzir esse exsudato permanente e executar uma técnica de descompressão. Após um ano de acompanhamento, os achados clínicos e radiográficos indicaram processo de reparo.

Efficacy and safety of parecoxib in the treatment of acute renal colic: a randomized clinical trial.

PURPOSE: Although non-selective non-steroidal anti-inflammatory drugs (nsNSAIDs) and opioids are effective treatments for acute renal colic, they are associated with adverse events (AEs). As cyclooxygenase-2 selective NSAIDs may provide a safer alternative, we compared the efficacy and safety of parecoxib versus an nsNSAID in subjects with acute renal colic. MATERIALS AND METHODS: Phase IV., multicenter, double-blind, noninferiority, active-controlled study: 338 subjects with acute renal colic were randomized to parecoxib 40 mg i.v. plus placebo (n = 174) or ketoprofen 100 mg IV plus placebo (n = 164). 338 subjects with acute renal colic were randomized to parecoxib 40 mg IV (n = 174) or ketoprofen 100 mg IV(n = 164) plus placebo. Subjects were evaluated 15, 30, 45, 60, 90 and 120 minutes after treatment start and 24 hours after discharge. Primary endpoint was the mean pain intensity difference (PID) at 30 minutes by visual analog scale (VAS) (per-protocol population). An ANCOVA model was used with treatment group, country, and baseline score as covariates. Non-inferiority of parecoxib to ketoprofen was declared if the lower bound of the 95% confidence interval (CI) for the difference between the two groups excluded the pre-established margin of 10 mm for the primary endpoint. RESULTS: Baseline demographics were similar. The mean (SD) mPID30 min was 33.84 (24.61) and 35.16 (26.01) for parecoxib and ketoprofen, respectively. For treatment difference (parecoxib-ketoprofen) the lower bound of the 95% CI was 6.53. The mean change from baseline in VAS 30 minutes after study medication was ~43 mm; AEs were comparable between treatments. CONCLUSIONS: Parecoxib is as effective as ketoprofen in the treatment of pain due to acute renal colic, is well tolerated, and has a comparable safety profile.

A randomized double-blind study comparing the efficacy and safety of orlistat versus placebo in obese patients with mild to moderate hypercholesterolemia.

INTRODUCTION: Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. OBJECTIVE: To evaluate the efficacy of orlistat for weight loss and improved lipid profile compared to placebo in obese patients with hypercholesterolemia, treated over a period of 6 months. METHODOLOGY: In a 6-month, multicenter (10 centers in Portugal), double-blind, parallel, placebo-controlled study, 166 patients, aged 18-65 years, body mass index (BMI) > or = 27 kg/m2, LDL cholesterol > 155 mg/dl, were randomized to a reduced calorie diet (600 kcal/day deficit) plus orlistat three times a day or placebo. Exclusion criteria included triglycerides > 400 mg/dl, severe cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes under pharmacological treatment, and gastrointestinal or pancreatic disease. RESULTS: The mean difference in weight from baseline was 5.9% (5.6 kg) in the orlistat group vs. 2.3% (2.2 kg) in the placebo group. In the orlistat group 49% of patients achieved 5-10% weight loss and 8.8% achieved > 10%. The orlistat group showed a significant reduction in total and LDL cholesterol, with similar changes for HDL in both treatment groups. The frequency of gastrointestinal adverse events was slightly higher in the orlistat group than in the placebo group, leading to discontinuation in 7 patients. CONCLUSION: Treatment with orlistat plus a reduced calorie diet for 6 months achieved significant reductions in weight, BMI and lipid parameters.

Paraganglioma presenting as stress cardiomyopathy: case report and literature review.

Pheochromocytoma/paraganglioma (PPGL) are neuroendocrine tumors that can secrete catecholamines. The authors describe a challenging case who presented as stress cardiomyopathy and myocardial infarction (MI). A 76-year-old man, with a medical history of Parkinson's disease, type 2 diabetes mellitus, hypertension, dyslipidaemia and a previous inferior MI in 2001, presented to the emergency department due to chest pain, headaches and vomiting. He also reported worsening blood glucose levels and increasing constipation over the preceding weeks. BP was 185/89 mmHg (no other relevant findings). EKG had ST segment depression in leads V2-V6, T troponin was 600 ng/L (<14) and the echocardiogram showed left ventricular hypokinesia with mildly compromised systolic function. Nevertheless, he rapidly progressed to severe biventricular dysfunction. Coronary angiogram showed a 90% anterior descendent coronary artery occlusion (already present in 2001), which was treated with angioplasty/stenting. In the following days, a very labile BP profile and unexplained sinus tachycardia episodes were observed. Because of sustained severe constipation, the patient underwent an abdominal CT that revealed a retroperitoneal, heterogeneous, hypervascular mass on the right (62 × 35 mm), most likely a paraganglioma. Urinary metanephrines were increased several fold. 68Ga-DOTANOC PET-CT scan showed increased uptake in the abdominal mass (no evidence of disease elsewhere). He was started on a calcium-channel blocker and alpha blockade and underwent surgery with no major complications. Eight months after surgery, the patient has no evidence of disease. Genetic testing was negative for known germline mutations. This was a challenging diagnosis, but it was essential for adequate cardiovascular stabilization and to reduce further morbidity. Learning points: PPGL frequently produces catecholamines and can manifest with several cardiovascular syndromes, including stress cardiomyopathy and myocardial infarction. Even in the presence of coronary artery disease (CAD), PPGL should be suspected if signs or symptoms attributed to catecholamine excess are present (in this case, high blood pressure, worsening hyperglycaemia and constipation). Establishing the correct diagnosis is important for adequate treatment choice. Inodilators and mechanical support might be preferable options (if available) for cardiovascular stabilization prior to alpha blockade and surgery. Laboratory interference should be suspected irrespective of metanephrine levels, especially in the context of treated Parkinson's disease.

Perfil sociodemográfico e de formação dos enfermeiros atuantes na atenção primária à saúde no Distrito Federal / Sociodemographic and training profile of nurses working in primary care health in the Federal District / Perfil sociodemográfico y formativo de los enfermeiros que actúan em atención primaria salud en el Distrito Federal

O objetivo do artigo foi analisar o perfil sociodemográfico e de formação acadêmica dos enfermeiros atuantes na Atenção Primária à Saúde no Distrito Federal. Os dados são oriundos da pesquisa "Práticas de Enfermagem no Contexto da Atenção Primária à Saúde: estudo nacional de métodos mistos"; foram coletados por questionário eletrônico e analisados pelo Statistical Package for the Social Sciences. Responderam ao questionário 329 enfermeiros incluídos pelos critérios de atuação em equipes de saúde da família ou cargos de gestão da atenção primária há pelo menos dois anos, que aceitaram participar do estudo nacional que originou os dados. Foram excluídos enfermeiros residentes, de licença de qualquer natureza ou que tenham recusado a participação. O estudo mostrou perfil sociodemográfico majoritariamente feminino, de meia idade, maioria de pessoas negras/pardas, casadas, católicas. A maioria dos profissionais não nasceu no município onde trabalha, mas optou por nele residir, e atua há 12 anos ou mais. Quanto à formação, a maior parte é graduada em instituições de ensino privadas brasileiras, com grande contingente de especialistas e quantidade reduzida de mestres, doutores e pós doutores. Nota-se influência da formação histórica e social da profissão no perfil da categoria, atravessada por questões elitistas, sexistas e racistas, interligadas às práticas de enfermagem, à estruturação do mundo do trabalho e ao reconhecimento social da profissional. Portanto, é necessário romper com o paradigma sociocultural e histórico excludente da formação profissional, para o progresso da autonomia, do reconhecimento e da valorização profissional. (AU)

The objective of the article was to analyze the sociodemographic profile and academic background of nurses working in Primary Health Care in the Federal District. Data come from the research "Nursing Practices in the Context of Primary Health Care: national study of mixed methods"; were collected by electronic questionnaire and analyzed using the Statistical Package for the Social Sciences. The questionnaire was answered by 329 nurses included according to the criteria of working in family health teams or in primary care management positions for at least two years, who agreed to participate in the national study that originated the data. Resident nurses, nurses on leave of any kind or those who refused to participate were excluded. The study showed a sociodemographic profile that was mostly female, middle-aged, mostly black/brown, married, Catholic. Most professionals were not born in the municipality where they work, but chose to live there, and have been working there for 12 years or more. As for training, the majority graduated from Brazilian private educational institutions, with a large contingent of specialists and a small number of masters, doctors and post-doctors. The influence of the profession's historical and social formation on the category's profile is noted, crossed by elitist, sexist and racist issues, interconnected with nursing practices, the structuring of the world of work and the social recognition of the professional. Therefore, it is necessary to break with the sociocultural and historical paradigm that excludes professional training, for the progress of autonomy, recognition and professional valuation. (AU)

El objetivo del artículo fue analizar el perfil sociodemográfico y la formación académica de los enfermeros que actúan en la Atención Primaria de Salud del Distrito Federal. Los datos provienen de la investigación "Prácticas de Enfermería en el Contexto de la Atención Primaria de Salud: estudio nacional de métodos mixtos"; fueron recogidos por cuestionario electrónico y analizados utilizando el Paquete Estadístico para las Ciencias Sociales. El cuestionario fue respondido por 329 enfermeros incluidos según el criterio de actuar en equipos de salud de la familia o en cargos de gestión de la atención primaria durante al menos dos años, que aceptaron participar en el estudio nacional que originó los datos. Se excluyeron las enfermeras residentes, las enfermeras con licencia de cualquier tipo o las que se negaron a participar. El estudio mostró un perfil sociodemográfico mayoritariamente femenino, de mediana edad, mayoritariamente negro/moreno, casado, católico. La mayoría de los profesionales no nacieron en el municipio donde trabajan, sino que eligieron vivir allí y tienen 12 años o más trabajando allí. En cuanto a la formación, la mayoría se graduó en instituciones educativas privadas brasileñas, con un gran contingente de especialistas y un pequeño número de maestros, doctores y posdoctorados. Se nota la influencia de la formación histórica y social de la profesión en el perfil de la categoría, atravesada por cuestiones elitistas, sexistas y racistas, interconectadas con las prácticas de enfermería, la estructuración del mundo del trabajo y el reconocimiento social del profesional. Por tanto, es necesario romper con el paradigma sociocultural e histórico que excluye la formación profesional, para el progreso de la autonomía, el reconocimiento y la valoración profesional. (AU)

Effect of light intensity and processing conditions on bioactive compounds in maté extracted from yerba mate (Ilex paraguariensis A. St.-Hil.).

This is the first report investigating the effects of cultivation, growth under full sunlight (MSL) or shade (MS), and processing (drying, sapeco and roasting) on the composition and antioxidant potential of maté. Samples were roasted (180 °C, 200 °C, 220 °C or 240 °C) for a fixed time (10 min) or roasted (10, 20, 30 or 40 min) at a fixed temperature (200 °C). HPLC/UV/MS analysis and measures of total phenolic content (TPC) and antioxidant activity (2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition and soybean oil oxidation) were used to analyse phytochemicals. There were significant differences (p < 0.05, ANOVA/Tukey) in phenolics between MS and MSL samples following certain processing steps, but Principal Component Analysis (PCA) indicated no distinction between MS and MSL samples, suggesting that light intensity had no effect on phenolics. Caffeine increased significantly (p < 0.05) in MS samples. Temperature was more important than time, since pyrolysis of phenolics was more intense at 240 °C.

Prevalence of Metabolic Syndrome and Framingham Risk Score in Apparently Healthy Vegetarian and Omnivorous Men.

BACKGROUND: Recent studies have shown a lower prevalence of metabolic syndrome (MSyn) in vegetarians (VEG) despite the inconclusive evidence from others. OBJECTIVE: To verify the association between diet and other lifestyle characteristics and the prevalence of MSyn, cardiovascular risk factors (CRF), and Framingham Risk Score (FRS) in apparently healthy VEG and omnivorous (OMN) men. METHODS: In this cross-sectional study, 88 apparently healthy men ≥ 35 years, 44 VEG and 44 OMN, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C-reactive protein (CRP) and FRS. To test the association between lifestyle and MSyn, Student t test, chi-square test, and multiple logistic regression model were used. A significance level of 5% was considered in all statistical analyses. RESULTS: Several CRF were significantly lower in VEG than in OMN: body mass index, systolic blood pressure, diastolic blood pressure, fasting serum total cholesterol, LDL-cholesterol, apolipoprotein b, glucose, and glycated hemoglobin (all p < 0.05). The FRS mean was lower in VEG than in OMN (2.98 ± 3.7 vs 4.82 ± 4.8, p = 0.029). The percentage of individuals with MSyn was higher among OMN than among VEG (52.3 vs.15.9%) (p < 0.001). The OMN diet was associated with MSyn (OR: 6.28 95%CI 2.11-18.71) and alterations in most MSyn components in the multiple regression model independently of caloric intake, age and physical activity. CONCLUSION: The VEG diet was associated with lower CRF, FRS and percentage of individuals with MSyn.

Emotional disorders, parafunctional habits, and bruxism in hospital healthcare professionals in the COVID-19 post-pandemic period: a cross-sectional observational study / Alterações emocionais, hábitos parafuncionais e bruxismo em profissionais de saúde de ambiente hospitalar no período pós-pandemia de COVID-19: um estudo observacional descritivo / Cambios emocionales, hábitos parafuncionales y bruxismo en profesionales de la salud en el ámbito hospitalario en el período pospandemia por COVID-19: un estudio observacional descriptivo

ABSTRACT During the COVID-19 pandemic, hospital healthcare professionals (HHP) were vulnerable to sources of anxiety that can lead to the onset or worsening of conditions such as bruxism and parafunctional habits (PH). This study aims to evaluate the relationship between sleep bruxism (SB), awake bruxism (AB), and PH and HHP's stress, anxiety, and depression in the post-pandemic period. Data were collected via an online questionnaire composed of four sections: sample characterization, "Depression, Anxiety and Stress Scale" (DASS-21), "Oral Behavior Checklist" (OBC), and diagnostic questionnaire of SB from the American Academy of Sleep Medicine. This is a descriptive and inferential statistical analysis with 118 responses (mostly females and nurses). A total of 99.2% of the sample presented PH, 38.1% SB, and 686% AB. We found a significant association between AB and stress (p=0029), anxiety (p=0005), and depression (p=0.004); SB and anxiety (p=0.013); and between SB and AB and emotional changes in the studied sample.

RESUMO Durante a pandemia da COVID-19, os profissionais de saúde de ambiente hospitalar (PSAH) estiveram vulneráveis a fontes de ansiedade que podem conduzir ao surgimento ou agravamento de condições como o bruxismo e os hábitos parafuncionais. Foi objetivo deste estudo avaliar a relação entre o bruxismo do sono (BS), da vigília (BV) e os hábitos parafuncionais (HP) e o estresse, a ansiedade e a depressão em PSAH no período pós-pandemia. Os dados foram recolhidos através de questionário online dividido em quatro secções: caracterização da amostra, escala de ansiedade, depressão e estresse (EADS-21), lista de avaliação de comportamentos orais (Laco) e questionário de diagnóstico de BS da Academia Americana de Medicina do Sono. Em seguida, procedeu-se à análise estatística descritiva e inferencial. A amostra foi composta de 118 respostas, sendo a maioria do sexo feminino e enfermeiros. Do total, 99,2% apresentou HP, 38,1% BS e 68,6% BV. Houve associação significativa entre BV e estresse (p=0,029), ansiedade (p=0,005) e depressão (p=0,004); entre BS e ansiedade (p=0,013); e entre BS e BV e as alterações emocionais na amostra em estudo.

RESUMEN Durante la pandemia del COVID-19, los profesionales de la salud en el ámbito hospitalario (PSAH) estuvieron expuestos a focos de ansiedad que podían conducirles al surgimiento o empeoramiento de condiciones como el bruxismo y hábitos parafuncionales. El objetivo de este estudio fue evaluar la relación entre el bruxismo del sueño (BS), bruxismo de la vigilia (BV) y hábitos parafuncionales (HP) con el estrés, la ansiedad y la depresión en PSAH en el período pospandémico. Los datos se recolectaron de un cuestionario en línea, dividido en cuatro secciones: caracterización de la muestra, escala de ansiedad, depresión y estrés (EADS-21), lista de evaluación del comportamiento oral (LACO) y cuestionario de diagnóstico de BS de la Academia Americana de Medicina del Sueño. Luego, se realizó un análisis estadístico descriptivo e inferencial. La muestra constó de 118 respuestas, y su mayoría era mujeres y enfermeras. Del total, el 99,2% tenía HP; el 38,1% BS; y el 68,6% BV. Hubo asociación significativa entre BV y estrés (p=0,029), ansiedad (p=0,005) y depresión (p=0,004); entre BS y ansiedad (p=0,013); y entre BS y BV, además de cambios emocionales en la muestra del estudio.

Better Adequacy of Food Intake According to Dietary Recommendations of National Cholesterol Education Program in Vegetarian Compared to Omnivorous Men

Abstract Background The lower frequency of cardiovascular (CV) risk factors observed in vegetarians compared to omnivores may be due to more appropriate nutrient intake according to recommendations for the prevention of cardiovascular diseases. Objective To compare the dietary adequacy according to the recommendations of the National Cholesterol Education Program (NCEP) in apparently healthy vegetarian (VEG) and omnivorous (OMN) men. Methods This was a cross-sectional study, conducted with apparently healthy men (44 omnivorous and 44 vegetarians, ≥ 35 years), who were assessed for daily food consumption, anthropometric data, physical exercise status, and clinical data. Multiple logistic regression was used to test the association between the type of diet and the dietary adequacy. Significant values were considered for p<0.05. Results Several clinical CV risk markers were significantly lower in VEG when compared to OMN: body mass index (BMI) (23.1 vs. 27.3 kg/m2), systolic blood pressure (119.5 vs. 129.2 mmHg), and diastolic blood pressure (75.7 vs. 83.9 mmHg). VEG presented significant lower values of blood lipids and glucose. No significant difference was observed in caloric intake; however, VEG consumed significantly more carbohydrates, dietary fibers, and polyunsaturated fats. VEG presented an adequate consumption of dietary cholesterol and saturated and polyunsaturated fatty acids, regardless of caloric intake and age. Conclusion VEG were more likely to consume saturated fatty acids, dietary cholesterol, and fibers according to the recommendations of NCEP, factors that may contribute to lower levels of CV risk markers than OMN.

Management of periapical lesion with persistent exsudate

Resumo Este relato de caso descreve o tratamento e acompanhamento de um molar inferior em uma jovem de 18 anos com cisto periapical. Assim, torna-se importante saber quais opções devemos tomar diante de uma situação clínica que não podemos resolver pelos métodos convencionais, e quais técnicas e abordagens temos para alcançar o sucesso do tratamento. Este caso mostrou o plano de tratamento e acompanhamento, por meio de imagens de tomografia computadorizada de feixe cônico (TCFC), de um molar inferior previamente tratado com grande abscesso periapical e lesão cística, no qual, a primeira abordagem do plano de tratamento foi fazer o retratamento endodôntico. Durante o preparo químico-mecânico a presença de exsudato purulento intracanal permanente impossibilitou a secagem dos canais, impedindo a obturação do sistema de canais radiculares. Devido a essa situação clínica, foi realizada abordagem cirúrgica com a intenção de reduzir esse exsudato permanente e executar uma técnica de descompressão. Após um ano de acompanhamento, os achados clínicos e radiográficos indicaram processo de reparo.

Abstract This case describes the treatment and follow-up of a mandibular molar in an 18-year-old female with a periapical cyst. Thus, it becomes important to know which options should we take when faced with a clinical situation that we cannot resolve through conventional methods, and which techniques and approaches we have to achieve treatment success. This case showed the treatment plan and follow-up, by the use of CBCT images, from a previously treated mandibular molar with a large periapical abscess and cystic lesion, in which, the first treatment plan approach was to make the endodontic retreatment. During the chemo-mechanical preparation the presence of permanent intracanal purulent exudate made it impossible to dry the canals, impeding obturation of the root canal system. Due to this clinical situation, a surgical approach was performed with the intention of reduce this permanent exudate and to execute a decompression technique. Clinical findings, periapical radiographs and cone beam computed tomographic, indicated almost complete resolution of the radiolucency, after a one-year follow-up.

Reduced subclinical carotid vascular disease and arterial stiffness in vegetarian men: The CARVOS Study.

BACKGROUND: Dietary habits play an important role in the development of atherosclerosis, the most important cause of morbidity and mortality in the world. The objective of this study was to verify if vegetarian (VEG) diet could be related a better profile of subclinical vascular disease evaluated by arterial stiffness and functional and structural properties of carotid arteries, compared to omnivorous (OMN) diet. METHODS: In this cross-sectional study, 44 VEG and 44 OMN apparently healthy men ≥35years of age, in order to not have confounding risk factors of subclinical atherosclerosis, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C reactive protein (CRP), and arterial stiffness determined by carotid-femoral pulse wave velocity (PWV). Also, carotid intima-media thickness (c-IMT) and distensibility were evaluated. RESULTS: VEG men had lower body mass index, systolic and diastolic blood pressures, fasting serum total cholesterol, LDL and non-HDL-cholesterol, apolipoprotein B, glucose and glycated hemoglobin values in comparison with OMN individuals (all p values <0.05). Markers of vascular structure and function were different between VEG and OMN: PWV 7.1±0.8m/s vs. 7.7±0.9m/s (p<0.001); c-IMT 593±94 vs. 661±128µm (p=0.003); and relative carotid distensibility 6.39±1.7 vs. 5.72±1.8% (p=0.042), respectively. After a multivariate linear regression analysis, a VEG diet was independently and negatively associated with PWV (p value 0.005). CONCLUSIONS: A VEG diet is associated with a more favorable cardiovascular diseases biomarker profile and better vascular structural and functional parameters.

[Transient tachypnea of the newborn, obstetric and neonatal risk factors]. / Taquipnea transitoria del recién nacido, factores de riesgo obstétricos y neonatales.

OBJECTIVE: To identify the obstetrics and neonatal risk factors associated with transient tachypnea of the newborn. PATIENTS AND METHODS: Case-control study of 110 neonates with transient tachypnea and 110 newborns controls, between May and October 2000, in the Hospital Civil de Guadalajara Dr. Juan I. Menchaca. The diagnosis of transient tachypnea was done by clinical and radiology data and exclusion of the other causes of respiratory distress. The exposure was documented by a direct interview to the mother and clinical information of the clinical expedient. The association was measured with the odds ratios and confidence interval of 95%. RESULTS: The frequency of transient tachypnea was of 2 percent newborn alive. The risk factors that were associated with transient tachypnea was: low Apgar score at minute (OR: 33.74, CI 95%: 4.73-681.52), premature rupture of amniotic membranes (OR: 3.65, CI 95%: 1.53-8.90), cesarean section (OR: 2.01, CI 95%: 1.14-3.57) and masculine gender (OR: 2.02, CI 95%: 1.14-3.60). It was more frequent in the cases the antecedent of diabetes mellitus and bronchial asthma. CONCLUSIONS: The results suggest that it's necessary to improve the obstetrics surveillance to diminish the frequency of low Apgar score and risk factors associated with transient tachypnea of the newborn.

Aplicación del Método Autorregresivo Integrado de Medias Móviles para el análisis de series de casos de COVID-19 en el Perú / Application Of The Integrated Autoregressive Method Of Moving Averages For The Analysis Of Series Of Cases Of COVID-19 In Peru

Objetivo: Estimar un modelo Autorregresivo Integrado de Medias Móviles (ARIMA) para el análisis de series de casos de COVID-19, en Perú. Métodos: El presente estudio se basó en un análisis de series temporales univariante; los datos utilizados se refieren a la cantidad de casos nuevos acumulados de COVID-19 del 06 de marzo al 11 de junio de 2020. Para el análisis del ajuste del modelo se utilizaron los coeficientes de autocorrelación (ACF), el contraste de raíces unitarias de Dickey-Fuller Aumentado (ADF), el Criterio de Información Bayesiano Normalizado (BIC Normalizado), el error porcentual medio absoluto (MAPE) y el test de Box-Ljung. Resultados: El pronóstico de casos de COVID-19, entre el 12 de junio al 11 de julio de 2020 oscila entre 220 596 a 429 790. Conclusiones: Los resultados obtenidos con el modelo ARIMA, comparados con los datos observados, muestran un ajuste adecuado de los valores; y aunque este modelo, de fácil aplicación e interpretación, no simula el comportamiento exacto en el tiempo puede considerarse una herramienta simple e inmediata para aproximar el numero de casos.

Objective: To estimate an Integrated Autoregressive Moving Average model (ARIMA) for the analysis of series of COVID-19 cases, in Peru. Methods: The present study was based on a univariate time series analysis; The data used refer to the number of new accumulated cases of COVID-19 from March 6 to June 11, 2020. For the analysis of the fit of the model, the autocorrelation coefficients (ACF), the unit root test of Augmented Dickey-Fuller (ADF), the Normalized Bayesian Information Criterion (Normalized BIC), the absolute mean percentage error (MAPE) and the Box-Ljung test. Results: The prognosis for COVID-19 cases, between June 12 and July 11, 2020 ranges from 220 596 to 429 790. Conclusions: The results obtained with the ARIMA model, compared with the observed data, show an adequate adjustment of the values; And although this model, easy to apply and interpret, does not simulate the exact behavior over time, it can be considered a simple and immediate tool to approximate the number of cases.

Peppermint antioxidants revisited.

This review discusses the relationship between the chemical composition and antioxidant property of peppermint tisane and essential oil. Phenolic acids (e.g. rosmarinic and caffeic acids), flavones (e.g. luteolin derivatives) and flavanones (e.g. eriocitrin derivatives) are possibly the major infusion antioxidants. Vitamin antioxidants (e.g. ascorbic acid and carotenoids) are minor contributors to the overall antioxidant potential. Unsaturated terpenes having a cyclohexadiene structure (e.g. terpinene) and minor cyclic oxygenated terpenes (e.g. thymol), may contribute to antioxidant potential whilst acyclic unsaturated oxygenated monoterpenes (e.g. linalool) may act as pro-oxidants in essential oil. Findings on the antioxidant potential of major cyclic oxygenated terpenes (menthol and menthone) are conflicting. Antioxidant behaviour of aqueous/organic solvent extracts and essential oil as well as the effect of environmental stresses on essential oil and phenolic composition are briefly discussed.