Detalhe da pesquisa
1.
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Bioorg Med Chem Lett
; 88: 129280, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054759
2.
Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
Bioorg Med Chem Lett
; 44: 128108, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991625
3.
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Bioorg Med Chem Lett
; 51: 128376, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560263
4.
An improved protocol for amino acid type-selective isotope labeling in insect cells.
J Biomol NMR
; 68(4): 237-247, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28711957
5.
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA).
J Biol Chem
; 287(16): 12657-67, 2012 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22378791
6.
Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
Acta Crystallogr F Struct Biol Commun
; 77(Pt 1): 22-28, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33439152
7.
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
J Med Chem
; 64(19): 14247-14265, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34543572
8.
Application of the Gyrolab microfluidic platform to measure picomolar affinity of a PD-L1-binding Adnectin™ radioligand for positron emission tomography.
Biotechniques
; 69(3): 200-205, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672060
9.
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 48(1): 141-51, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634008
10.
Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay.
AAPS J
; 17(4): 976-87, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25924887
11.
Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.
J Med Chem
; 56(10): 3783-805, 2013 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23547706
12.
Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.
J Med Chem
; 55(5): 1978-98, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22220566
13.
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.
Bioorg Med Chem Lett
; 17(21): 5853-7, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17869513
14.
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorg Med Chem Lett
; 17(21): 5934-9, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17827003
15.
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
Bioorg Med Chem Lett
; 16(5): 1346-9, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16332437
16.
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(20): 5373-7, 2006 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919457
17.
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 15(10): 2533-6, 2005 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15863311
18.
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Bioorg Med Chem Lett
; 15(9): 2253-8, 2005 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837304
19.
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
Biochem J
; 371(Pt 2): 525-32, 2003 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12529175
20.
Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 14(4): 859-63, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15012982