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1.
J Investig Allergol Clin Immunol ; 22(5): 313-30; quiz follow 330, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23101306

RESUMO

Correct management of latex allergy is essential to ensure adequate care of patients who are allergic to latex, which is ubiquitous in the health care setting. In this Position Paper, the Latex Committee of the Spanish Society of Allergology and Clinical Immunology provides guidelines for the management of latex allergy.


Assuntos
Hipersensibilidade ao Látex/diagnóstico , Alérgenos/imunologia , Exposição Ambiental , Humanos , Látex/imunologia , Hipersensibilidade ao Látex/prevenção & controle , Hipersensibilidade ao Látex/terapia
2.
Artigo em Inglês | MEDLINE | ID: mdl-21243937

RESUMO

Local reactions to glatiramer acetate are common, but few cases of hypersensitivity reaction have been reported. We present 3 patients with multiple sclerosis who suffered immediate-type local reactions after subcutaneous injection of glatiramer acetate. Skin prick test (SPT), intradermal test (IDT), and determination of immunoglobulin (Ig) E to glatiramer acetate were performed in patients and controls (enzyme-linked immunosorbent assay). The results of SPT were all negative. Those of IDT in controls were negative at concentrations below 200 microg/mL, but positive for patients 1, 2, and 3 at 2, 20, and 200 microg/mL, respectively. Serum IgE to glatiramer acetate in patient 1 was 2.1 times higher than in the controls, whereas no differences were found between controls and patients 2 and 3. Glatiramer acetate was safely reintroduced in patients 2 and 3. The results obtained for patient 1 suggest that an IgE-mediated mechanism was probably involved. In conclusion, IDT and serum IgE determination to glatiramer acetate seem useful for identifying allergic reactions among the common local reactions induced by this drug.


Assuntos
Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade Imediata/diagnóstico , Esclerose Múltipla/tratamento farmacológico , Peptídeos/efeitos adversos , Adulto , Ensaio de Imunoadsorção Enzimática , Feminino , Acetato de Glatiramer , Humanos , Imunoglobulina E/sangue , Injeções Subcutâneas , Pessoa de Meia-Idade , Peptídeos/imunologia , Testes Cutâneos
3.
Artigo em Inglês | MEDLINE | ID: mdl-20232769

RESUMO

BACKGROUND: Grass pollen allergy is one of the most common allergies worldwide, and patients often show sensitization to an array of phylogenetically related species. OBJECTIVE: To determine the effect of specific immunotherapy (SIT) with Phleum pratense extract on induction of the immune response to a mixture composed of 5 grass pollen extracts. METHODS: Forty-six adult patients suffering from rhinitis and sensitized to a mix of grass pollen allergen extracts were randomized 3:1 to receive a short course of SIT with P. pratense or to an open control group without SIT. At baseline and after 3-4 months, we evaluated levels of specific immunoglobulin (Ig) E and IgG4, as well as the immediate and delayed cutaneous responses to the grass mix and P. pratense. IgG4 to Lolium perenne was also determined. RESULTS: Levels of IgE and IgG4 to grass mix and P. pratense increased significantly during treatment (P<.001). However, this increase was only significantly higher in the SIT group than in the control group for IgG4 (P<.001). The levels of IgG4 to Phl p 5 and Lol p 5 were highly correlated (r=0.99, P<.001). The immediate and delayed cutaneous responses were significantly diminished to both extracts after SIT (P<.001). CONCLUSIONS: Patients with rhinoconjunctivitis diagnosed using skin prick testing with a grass mix allergen extract and treated with a short course of SIT based on a single species P. pratense allergen extract are able to develop an immune response that targets not only the immunizing species, but also the grass mix allergen extract.


Assuntos
Alérgenos/imunologia , Dessensibilização Imunológica , Phleum/imunologia , Poaceae/imunologia , Rinite Alérgica Sazonal/terapia , Adulto , Reações Cruzadas , Feminino , Humanos , Imunoglobulina E/sangue , Imunoglobulina G/sangue , Masculino , Rinite Alérgica Sazonal/imunologia , Testes Cutâneos
4.
J Investig Allergol Clin Immunol ; 19(3): 167-72, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19610258

RESUMO

OBJECTIVE: Allergic rhinitis can determine the presence and type of asthma. The main aim of this study was to evaluate the link between allergic rhinitis, asthma, and skin test sensitization in patients with allergic rhinitis. METHODS: Patients with allergic rhinitis, aged 10 to 50 years, were consecutively enrolled at different allergy centers in Spain and Portugal. All the patients underwent skin prick tests with a panel of 20 biologically standardized aeroallergens. Allergic rhinitis was classified according to etiology and the Allergic Rhinitis and its Impact on Asthma guidelines and asthma was classified according to the Global Initiative for Asthma guidelines. RESULTS: A total of 3225 patients, with a mean age of 27 years, were evaluated. House dust mites and grass and olive tree pollens were the most common aeroallergens. The mean (SD) number of positive skin tests per patient was 6.5 (4), the mean wheal size was 42.3 (28) mm2, and the mean atopy index was 6.5 (2). Forty-nine percent of the patients had concomitant asthma. Asthma severity was associated with a longer time since onset (P < .04) and allergic rhinitis severity (P < .001). Patients with concomitant asthma had a significantly higher number of aeroallergens and sensitization intensity than those without asthma (P < .001). CONCLUSIONS: In this broad population sample, the presence and type of asthma was influenced by skin sensitization and both time since onset and severity of allergic rhinitis.


Assuntos
Asma/epidemiologia , Rinite Alérgica Perene/epidemiologia , Adolescente , Adulto , Poluentes Atmosféricos/imunologia , Alérgenos/imunologia , Asma/imunologia , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Portugal/epidemiologia , Rinite/imunologia , Rinite Alérgica Perene/imunologia , Dermatopatias/imunologia , Testes Cutâneos , Espanha/epidemiologia , Adulto Jovem
5.
J Investig Allergol Clin Immunol ; 19(4): 317-20, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19639729

RESUMO

Antihistamines are widely used drugs. Hypersensitivity reactions with these drugs are rare and a challenge for the physician. We describe 5 outpatients who experienced urticaria after taking antihistamines. All 5 were treated at our outpatient clinic over a period of 15 years. The allergy workup included a clinical history, skin prick testing, patch testing with antihistamines, and single-blind placebo-controlled oral challenge tests. Biopsy samples were taken and serum tryptase levels were determined in 1 patient. The results of the skin prick tests and patch tests were negative in all patients but 1, in whom the prick test result was positive to some antihistamines. We confirmed all diagnoses using a single-blind challenge test. The biopsy obtained from 1 patient strongly supported urticaria. We present 5 cases of antihistamine-induced urticaria where the immunologic mechanism remains unclear. Hypersensitivity reactions should be taken into account in patients receiving antihistamines, especially in those who experience urticaria.


Assuntos
Hipersensibilidade a Drogas/imunologia , Antagonistas dos Receptores Histamínicos/efeitos adversos , Urticária/induzido quimicamente , Adulto , Biópsia , Testes de Provocação Brônquica , Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pele/patologia , Testes Cutâneos
6.
An Med Interna ; 25(4): 163-7, 2008 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-18604331

RESUMO

INTRODUCTION: Hypersensitive reactions to analgesics in the general population are less than 1%. Previous studies have demonstrated that cyclooxigenase 2 (COX-2) inhibitors are an efficient alternative in patients with non-steroidal anti-inflammatory drugs (NSAIDs) intolerance. The aim of our study is to test the tolerance to celecoxib and meloxicam in patients with NSAIDs intolerance, upto dosages higher than those used in previous studies. MATERIAL AND METHODS: The subjects of the study were 38 NSAID-sensitive patients from September 2004 to June 2005. The diagnosis of intolerance to NSAIDs was carried out by means of single-blind placebo-controlled oral challenge with aspirin. We performed single-blind placebo controlled oral challenge tests with celecoxib (accumulated dose of 400 mg) and meloxicam (accumulated dose of 15 mg). RESULTS: There was only one reaction with celecoxib (97.3%) which was generalised urticaria after the dose of 400 mg accumulated, it should be pointed out that this patient tolerated perfectly the dose of 200 mg. For meloxicam, we found 100% tolerance at a dosage of 15 mg, including the patient who showed a reaction to the celecoxib. CONCLUSION: We consider that there are patients with tolerance to low dosages of COX-2 inhibitors who show a reaction on increasing the administered dosage, which means that their tolerance should be taken into account and checked in the long term.


Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Inibidores de Ciclo-Oxigenase/uso terapêutico , Pirazóis/uso terapêutico , Sulfonamidas/uso terapêutico , Tiazinas/uso terapêutico , Tiazóis/uso terapêutico , Celecoxib , Inibidores de Ciclo-Oxigenase/administração & dosagem , Feminino , Humanos , Masculino , Meloxicam , Pessoa de Meia-Idade , Pirazóis/administração & dosagem , Método Simples-Cego , Sulfonamidas/administração & dosagem , Tiazinas/administração & dosagem , Tiazóis/administração & dosagem
9.
An Med Interna ; 24(2): 72-4, 2007 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-17590092

RESUMO

The skin prick test (SPT) is a simple and fast method used routinely in allergology practice. Systemic reactions have been described with this technique on few occasions. We are presenting a case of anaphylaxis with hemodynamic consequences after carrying out skin prick test with a cat dander extract. A 23 years old female who suffered rhinoconjunctivitis and asthma following contact with cats. We performed skin prick test with a battery of the usual inhalants. Twenty minutes after carrying out the prick test the patient showed intense ocular irritation and reddening followed by dysphonia and a feeling of pharyngeal occupation. Although skin prick test is a safe diagnostic approach, it should be performed only in places equipped to treat anaphylaxis and for trained specialists .


Assuntos
Anafilaxia/etiologia , Testes Cutâneos/efeitos adversos , Adulto , Feminino , Humanos
11.
Eur Ann Allergy Clin Immunol ; 38(6): 186-94, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16929745

RESUMO

BACKGROUND: Allergic rhinitis (AR) is a prevalent allergic disease in Iberian countries, but there are no recent epidemiological studies that characterize this pathology according to clinical classification and aeroallergens sensitisation. This is a clinical study, representative of each country METHODS: Descriptive, observational cross-sectional, population-based study carried-out in Portugal and Spain. 3397 consecutive patients (5 regions in Spain and 3 regions in Portugal) were selected for clinical observation and skin prick tests were carried out using the same panel of standardized aeroallergens. RESULTS: 3225 patients (aged 10-50 years old) completed the study (IC 95%, SE 15). Intermittent rhinitis makes up 36% of the entire sample. Of them, intermittent AR mild forms represented 82% in Spain and 92% in Portugal that is, 87% for Iberian countries. Persistent types of rhinitis showed exactly the same rate of severity in Portugal and Spain, 44% mild and 56% moderate/severe. Seasonal forms represent 37% while 63% were perennial. BA was present in 49% of AR patients. There were significant differences between aeroallergens according to the different regions considered. Mites and grass pollens are the most relevant aeroallergens in Spanish and Portuguese AR patients, while Alternaria showed higher positive rates among 10-20 year old patients. CONCLUSIONS: This study characterizes the AR patients in Iberian countries according to the ARIA classification. No correlation was observed between this classification and the conventional (seasonal/perennial). Our results also characterize the allergic cutaneous pattern of aeroallergen sensitisation using the same panel of standardized allergens and show differences between the different regions analysed.


Assuntos
Poluição do Ar , Alérgenos/imunologia , Rinite Alérgica Perene/epidemiologia , Rinite Alérgica Sazonal/epidemiologia , Adolescente , Adulto , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Portugal , Prevalência , Fatores Sexuais , Testes Cutâneos , Espanha
12.
Artigo em Inglês | MEDLINE | ID: mdl-15864879

RESUMO

This randomised, double-blind, parallel-group, multicentre clinical trial evaluated the efficacy and safety of rupatadine, a new antihistamine with antiplatelet-activating factor (PAF) activity, and cetirizine in the treatment of patients with seasonal allergic rhinitis (SAR). A total 249 patients were randomised to receive rupatadine 10 mg once daily (127 patients) or cetirizine 10 mg (122 patients) for two weeks. The main efficacy variable was the mean total daily symptom score (mTDSS) and was based on the daily subjective assessment of the severity of each rhinitis symptom--nasal (runny nose, sneezing, nasal itching and nasal obstruction) and non-nasal (conjunctival itching, tearing, and pharyngeal itching)--recorded by patients in their diaries. The mTDSS was 0.7 for both treatment groups (intention to treat analysis). In the investigator's global evaluation of efficacy at the seventh day, 93.3% and 83.7% patients in the rupatadine and cetirizine groups, respectively, showed some or great improvement (p = 0.022). In the per protocol analysis (n = 181), runny nose at the seventh day of treatment was absent or mild in 81.1% of patients in the rupatadine group and in 68.6% of patients in the cetirizine group (p = 0.029). In any case statistical significance was not maintained at the second week. Overall, all treatments were well tolerated. Adverse events (AEs) were similar in both treatment groups, i.e. headache, somnolence and fatigue/asthenia as the most often reported. Somnolence was reported in 9.6% and 8.5% of patients treated with rupatadine or cetirizine, respectively. The most reported AEs (67%) were mild in intensity. Our results suggest that rupatadine 10 mg may be a valuable and safe alternative for the symptomatic treatment of SAR.


Assuntos
Antialérgicos/administração & dosagem , Cetirizina/administração & dosagem , Ciproeptadina/análogos & derivados , Ciproeptadina/administração & dosagem , Antagonistas não Sedativos dos Receptores H1 da Histamina/administração & dosagem , Antagonistas dos Receptores Histamínicos H1/administração & dosagem , Rinite Alérgica Sazonal/tratamento farmacológico , Adolescente , Adulto , Idoso , Criança , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fator de Ativação de Plaquetas/antagonistas & inibidores , Resultado do Tratamento
13.
An Med Interna ; 22(12): 586-8, 2005 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-16454598

RESUMO

Mesalazine is a derivative of 5-aminosalicylic acid (5-ASA), which is useful in the treatment of intestinal inflammatory disease. Sulfasalazine is formed by two parts, sulfapyridine and 5-ASA, the latter being the active part of the molecule. The new preparatives derived from 5-ASA were developed in an attempt to avoid the traditionally associated side effects to sulfapyridine, although they are still observed and new effects appear. We present two cases. The first is a man diagnosed of inflammatory intestinal disease, with background of two previous reactions of urticaria and angioedema after acetyl salicylic acid, who presented urticaria after taking mesalazine. The second one had generalized urticaria after three months of initiating treatment with mesalazine. Given the need for treatment in both cases, a desensitization protocol to mesalazine was made. It was developed in 17 days in our service. Tolerance to that drug to therapeutic doses is reached. When faced with patients with hypersensitivity to different drugs, that are necessary to treat their disease, "desensitization" regimes, that assure good tolerance, can be made.


Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Dessensibilização Imunológica , Hipersensibilidade a Drogas/terapia , Mesalamina/efeitos adversos , Adulto , Humanos , Masculino , Urticária/induzido quimicamente
15.
Clin Microbiol Infect ; 9(5): 453-7, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12848764

RESUMO

Thirty-two patients with abdominal pain and/or intestinal pseudo-obstruction who had consumed raw or undercooked fish in the previous 72 h, were included in a study of anisakiasis, a parasitation of the human gastrointestinal tract by third stage Anisakis simplex larvae. Skin prick test (SPT) against A. simplex were positive in all the patients. High median eosinophil cationic protein (ECP) serum concentrations (> 15 mg/L) at day 0 with normal serum levels at day 30 and a rise of median total and specific IgE against A. simplex at day 30, were observed. We conclude that a raised serum level of ECP in the first 72 h from the onset of symptoms coinciding with a positive SPT against A. simplex and high total and specific immunoglobulin (IgE) in the first month after the parasitation, could be a useful tool in the diagnosis of gastrointestinal anisakiasis, even if the parasite cannot be isolated.


Assuntos
Anisaquíase/diagnóstico , Proteínas Sanguíneas/análise , Gastroenteropatias/diagnóstico , Ribonucleases , Doença Aguda , Adulto , Animais , Anisakis/isolamento & purificação , Sistema Digestório/parasitologia , Proteínas Granulares de Eosinófilos , Peixes , Gastroenteropatias/parasitologia , Humanos , Imunoglobulina E/análise , Larva/crescimento & desenvolvimento , Pessoa de Meia-Idade , Testes Sorológicos
16.
Artigo em Inglês | MEDLINE | ID: mdl-10582204

RESUMO

Azathioprine is an immunosuppressant drug which is an analog to 6-mercaptopurine and has been used in the last 20 years to prevent organ transplant rejection. It has also been used in the treatment of some autoimmunological diseases. We present a case of a 24-year-old woman with systemic lupus erythematosus, suffering from nephritis, who developed angioedema after using azathioprine to control her illness. She had never reported similar episodes. The involvement of the drug was demonstrated by positive oral challenge test without changes in biochemical and complement blood determinations. She reached tolerance to the drug after a desensitization procedure (increasing 5 mg each day to reach 125 mg daily). We are not able to propose the involvement of an IgE-mediated mechanism, but rather a hypersensitive one with a non-dose-dependent effect. These desensitization procedures show great potential as therapeutic safeguards against harmful drugs in some patients. We have not found any other desensitization procedure for this drug.


Assuntos
Angioedema/induzido quimicamente , Azatioprina/efeitos adversos , Azatioprina/imunologia , Dessensibilização Imunológica , Adulto , Tolerância a Medicamentos/imunologia , Feminino , Humanos , Imunossupressores/efeitos adversos , Imunossupressores/imunologia , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Nefrite Lúpica/tratamento farmacológico
17.
J Investig Allergol Clin Immunol ; 14(2): 108-13, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15301299

RESUMO

BACKGROUND: Bronchial mucosal inflammation is the major pathogenic process in asthma. In the latest years, induced sputum (IS) examination has become an important non-invasive method of assessing airway inflammation. Flow cytometry has been recently applied to the study of IS though it is not exempt of methodological difficulties. The aim of the present study was to further study if the fluorocytometric analysis of IS could represent a reliable tool to assess the presence of bronchial activated lymphocytes in stable mild asthmatic patients. METHODS: Induced sputa from controls and asthmatic patients were processed in isotonic 3mM dithiothreitol (DTT), a mucolytic agent required for cell dispersion. The individualized cells were then stained with monoclonal antibodies for three-colour flow-cytometric analysis. Total IgE and ECP were measured in serum and in the sputum fluid phase. RESULTS: The cellularity of asthmatic sputa is enriched in eosinophils (mean, 26.63%) with respect to controls, but not in lymphocytes. However, lymphocytes from asthmatics show increased surface expression of activation markers (CD25 in T cells, CD23 in B cells). Surprisingly, no differences were observed in the detected levels of CD54 on IS lymphocytes and eosinophils between asthmatics and non-asthmatics. Furthermore, there was a significantly higher concentration of ECP and total IgE in the sputum from the asthmatic group. CONCLUSION: Fluorocytometric analysis of induced sputum is a reliable non-invasive method for the study of bronchial immune cells. It could provide complementary information on activated cells in the bronchial mucosa even in non-smokers, mild and stable asthmatics and it is reasonable to speculate that it will be useful in monitoring the effect of the treatment in these patients.


Assuntos
Asma/imunologia , Escarro/citologia , Escarro/imunologia , Adulto , Antígenos CD/imunologia , Asma/sangue , Asma/patologia , Proteína Catiônica de Eosinófilo/sangue , Eosinófilos/imunologia , Citometria de Fluxo , Humanos , Imunoglobulina E/sangue , Contagem de Linfócitos , Escarro/química
18.
Artigo em Inglês | MEDLINE | ID: mdl-11642573

RESUMO

Adverse reactions caused by benzodiazepines rarely occur. We present a case of a 70-year-old man who developed a maculopapular exanthema after the ingestion of tetrazepam. For his diagnosis, skin tests were performed, including prick and patch tests, not only with the benzodiazepine implicated in the reaction, but also with benzodiazepines of other groups. Single-blind oral challenge tests were also performed in the patient, in order to assess his tolerance to other benzodiazepines.


Assuntos
Ansiolíticos/efeitos adversos , Benzodiazepinas , Relaxantes Musculares Centrais/efeitos adversos , Idoso , Hipersensibilidade a Drogas/etiologia , Humanos , Masculino
19.
J Investig Allergol Clin Immunol ; 14(3): 214-20, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15552715

RESUMO

BACKGROUND: In spite of the frequency of chronic urticaria there are very few epidemiological studies of its prevalence and distribution. OBJECTIVE: We wanted to approach the real prevalence of chronic urticaria in a population-based study and to depict demographic distribution and personal perception of the disease. We also wanted to describe the frequency of acute urticaria episodes in the population studied. METHODS: We conducted a population-based study among adults in Spain. We questioned 5003 individuals after calculating a sample size for a maximum variability (conservative approach p=q=0.5). RESULTS: We found a 0.6% (95% CI: 0.4-0.8) prevalence of chronic urticaria. The prevalence is significantly higher in women than in men with a OR=3.82 (95%CI 1.56-9.37). Chronic urticaria is a self-limited disease, yet in 8.7% of cases chronic urticaria lasts from one to 5 years and in 11.3%, for more than 5 years. The average age of onset is 40 years. CONCLUSIONS: We offer large epidemiology study data on the prevalence of chronic urticaria. The prevalence of chronic urticaria has not yet been defined in an adult population-based study. With this work we offer such data to describe the prevalence and features of this disease.


Assuntos
Urticária/epidemiologia , Urticária/imunologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Doença Crônica , Intervalos de Confiança , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Probabilidade , Prognóstico , Índice de Gravidade de Doença , Distribuição por Sexo , Testes Cutâneos , Espanha/epidemiologia , Inquéritos e Questionários
20.
Rev Esp Enferm Dig ; 92(3): 132-9, 2000 Mar.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-10799943

RESUMO

OBJECTIVE: the ingestion of Anisakis simplex larvae may lead to the appearance of gastrointestinal symptoms. However, the number of reported cases of parasitization by Anisakis in Spain is lower than would be expected in a country with the second-highest fish consumption per inhabitant in the world, particularly since fish is often eaten raw or only slightly cooked. We suggest that the incidence of anisakiasis in Spain would be higher if complementary studies were used in all patients suspected of having anisakiasis. METHODS: we studied 6 patients with a diagnosis of intestinal obstruction who frequently ate fish. Skin prick tests with seafood, inhalant allergen and Anisakis extracts were done. Total and specific IgE against Anisakis larvae were tested with a CAP system radioimmunoassay and immunoblot assays. Oral challenge tests with frozen larvae were also used. RESULTS: a positive skin prick result and high levels of total and specific IgE were found in all patients. The results of immunoblot assays for IgE did not show a consistent pattern, but a group of several low (14-18 kDa) and intermediate molecular weight antigens (30-50 kDa) were found in all patients. All patients tolerated the oral challenge test well. CONCLUSIONS: in our patients with intestinal pseudo-obstruction and a history of frequent fish eating, the clinical and laboratory findings were suggestive of parasitization by Anisakis simplex larvae as the cause of the obstruction. Such complementary studies should be used whenever there is a suspicion of anisakiasis. The results of the oral provocation test show that the intake of dead larvae does not induce clinical parasitization.


Assuntos
Anisaquíase/complicações , Anisakis/imunologia , Doenças do Íleo/etiologia , Pseudo-Obstrução Intestinal/etiologia , Abdome Agudo/diagnóstico , Adulto , Anafilaxia/etiologia , Animais , Anisaquíase/diagnóstico , Anisaquíase/imunologia , Anticorpos Anti-Helmínticos/análise , Antígenos de Helmintos/análise , Diagnóstico Diferencial , Humanos , Doenças do Íleo/diagnóstico , Immunoblotting , Imunoglobulina E/análise , Pseudo-Obstrução Intestinal/diagnóstico , Larva/imunologia , Pessoa de Meia-Idade , Radioimunoensaio , Testes Cutâneos
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