Correlates of Alcohol Use Likelihood for Latino Immigrant Youth in an Emerging Context.

Using a three-wave prospective longitudinal design spanning 3 years, we assessed alcohol use likelihood trajectories and their correlates among a community sample of Latino immigrant adolescents in the emerging immigrant context of Western Oregon. Results from growth mixture modeling revealed two distinct classes: lower risk youth who reported little likelihood of alcohol use but whose trajectory was increasing, and higher risk youth who reported higher likelihood of alcohol use and whose trajectory was stable. We found significant differences between the two classes such that lower risk youth reported greater levels of Latino cultural orientation and parental monitoring, whereas higher risk youth reported greater levels of family cultural stress and delinquency. Results are discussed in terms of prior research and theory.

Effects of social support processes during implementation of community-based randomized controlled trials: An example from a culturally adapted replication trial for Latino families.

AIMS: Little work has considered the effects of salient interpersonal processes on the successful implementation and receipt of community-based interventions within randomized control trial designs. METHOD: Using data from the intervention arm (n = 120) of Nuestras Familias: Andando Entre Culturas (Our Families: Walking Between Cultures)-a community-based parent training intervention among Latino families-we assessed the effects of two common social support processes (group member and group leader support) during intervention delivery on participant satisfaction, use of intervention techniques at program termination, and longer-term parenting outcomes. RESULTS: Findings indicated that group member and leader social support predicted program satisfaction, and group leader support predicted greater use of intervention techniques at termination. However, social support processes did not predict longer-term parenting outcomes. CONCLUSION: Group member and leader support may help to promote higher consumer satisfaction and initial use of intervention techniques in a community intervention for Latinos.

Promoting Strong Latino Families Within an Emerging Immigration Context: Results of a Replication and Extension Trial of a Culturally Adapted Preventive Intervention.

We conducted a randomized controlled trial (RCT) of Nuestras Familias: Andando Entre Culturas, a culturally adapted evidence-based parent management training (PMT) preventive intervention, with a sample of 241 Spanish-speaking Latino parents and their middle-school-aged children residing in an emerging immigration context. Scientifically rigorous studies of programs designed for this setting are rare. The intervention was designed to promote prosocial parenting practices and to prevent youth substance use and related problem behaviors. The RCT was designed as an extension and replication of a prior trial (Martinez & Eddy in Journal of Consulting and Clinical Psychology, 73, 841-851, 2005) which was also conducted in an emerging immigration context. Two key issues were of primary interest: intervention feasibility and intervention efficacy. Intervention feasibility was assessed through weekly session attendance, participation, and parent-reported session satisfaction as well as overall program satisfaction. Intervention efficacy was assessed by comparing changes within the intervention and control groups on parenting practices and youth adjustment from pre-intervention baseline to post-intervention termination 6 months later. Results provided support for the feasibility of delivering the intervention on a large scale within communities. Consistent with the prior trial, positive effects of the intervention were detected on parenting practices and on youth outcomes. Differential effects of the intervention were detected based on youth gender and nativity status, such that girls benefited the most with respect to tobacco use likelihood, and foreign-born youth benefited the most with respect to decreased depressive symptoms.Findings provide additional evidence for Nuestras Familias as an efficacious family-based intervention for Latino families within communities that are sites of emerging immigration in terms of both improving parenting practices and decreasing risk for youth substance use and related problem behaviors.

Cultural stress, daily well-being, and internalizing and externalizing symptoms among Hispanic college students.

The present study was designed to examine the extent to which, in a sample of 873 Hispanic college students, daily levels of, and variability in, well-being would mediate the predictive effects of culturally related stressors (discrimination, negative context of reception, and bicultural stress) on internalizing and externalizing symptoms 11 days later. A 12-day daily diary design was utilized, where reports of cultural stressors were gathered on Day 1, daily well-being reports were gathered on Days 2-11, and outcomes were measured on Day 12 (with controls for Day 1 levels of these same outcomes). Structural equation modeling results indicated that daily means of, and variability in, well-being significantly mediated the predictive effect of Day 1 ethnic/racial discrimination, negative context of reception, and bicultural stress on Day 12 symptoms of anxiety and depression. No effects emerged for externalizing symptoms. When we decomposed the latent well-being variability construct into its component indicators (self-esteem, life satisfaction, psychological well-being/self-acceptance, and eudaimonic well-being), daily variability in life satisfaction and self-acceptance appeared to be primarily responsible for the mediated predictive effects we observed. These results are discussed in terms of implications for further research, for counseling practice, and for the development of more inclusive university practices and policies. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Parent immigration stress predicts youth externalizing behavior trajectories among Latino families in an emerging immigrant context.

According to ecodevelopmental and social learning models, Latino immigrant parents experience considerable stress associated with the immigration process, and such immigration-related stress is theorized to influence behavioral outcomes among their youth. Using a three-year longitudinal design among 217 Latino immigrant families in western Oregon, we assessed whether parents' (94% mothers, Mage  = 36.2 years) experience of immigration-related stress influenced the trajectory of their adolescents' (43% female, Mage = 13.4 years) externalizing behaviors. Controlling for covariates (gender, acculturation, age at migration, and gender), results showed that youth exhibited a normative downward trajectory for externalizing behaviors, and parents' experience of immigration stress significantly and negatively predicted this trajectory. Findings suggest that parents' experience of immigration stress may disrupt a normative trajectory of declining externalizing behaviors among Latino immigrant adolescents.

De acuerdo con los modelos de ecodesarrollo y de aprendizaje social, los padres inmigrantes latinos sufren bastante estrés asociado con el proceso de inmigración, y se cree que este estrés relacionado con la inmigración influye en los resultados conductuales entre sus hijos adolescentes. Utilizando un diseño longitudinal de tres años entre 217 familias de inmigrantes latinos del oeste de Oregon, evaluamos si el estrés sufrido por los padres debido a la inmigración (el 94 % madres, edad promedio = 36.2 años) influyó en la trayectoria de las conductas de exteriorización de sus hijos adolescentes (el 43 % de sexo femenino, edad promedio = 13.4 años). Teniendo en cuenta las covariables (el género, la aculturación, la edad al momento de la migración), los resultados indicaron que los adolescentes demostraron una trayectoria normativa descendente para las conductas de exteriorización, y que el estrés sufrido por los padres debido a la inmigración predijo significativamente y negativamente esta trayectoria. Los resultados indican que el estrés sufrido por los padres debido a la inmigración puede alterar una trayectoria normativa de disminución de las conductas de exteriorización entre los hijos adolescentes de inmigrantes latinos.

Discrimination Trends and Mental Health Among Native- and Foreign-Born Latinos: Results from National Surveys in 2004 and 2013.

We examined national trends and mental health correlates of discrimination among Latinos in the USA. We used data from two nationally representative surveys based on the National Epidemiologic Survey on Alcohol and Related Conditions collected in 2004 and 2013. Results indicated that perceived discrimination, both any and recurrent, increased for Latinos across nearly every demographic, with the greatest increases occurring for Latinos who were ages 65 and older, had household incomes less than $35,000, were less educated, were immigrants, and who lived in the Midwest. Findings also indicated that any and recurrent discrimination were associated with increased odds of a mood, anxiety, or substance use disorder and this association was observed for nearly all manifestations of discrimination. We also observed a dose-response association where experiencing discrimination in a greater number of domains was associated with increased likelihood of mood, anxiety, and substance use disorders. Results suggest that discrimination is a social stressor that has increased for Latino populations in recent years and may represent a serious risk factor for the psychological and behavioral health of Latinos. Findings are discussed in terms of prior research and the potential implications for prevention scientists working with Latino populations.

Toward a micro-level perspective on acculturation among U.S. Hispanic college students: A daily diary study.

OBJECTIVE: The present study introduces a daily, micro-level perspective on acculturation using a sample of Hispanic college students in Miami. METHODS: We conducted a 12-day diary study with a sample of first- and second-generation Hispanic college students in Miami. Outcome variables were measured on Days 1 and 12, and acculturation components (practices, identities, and values) were measured on Days 2-11. Daily fluctuations in acculturation components between Days 2 and 11 were examined as predictors of well-being, internalizing symptoms, and externalizing problems on Day 12. RESULTS: Fluctuations in comfort with speaking English negatively predicted three of the four well-being outcomes and positively predicted all of the internalizing and externalizing indicators. Fluctuations in collectivist values predicted two of the well-being outcomes and both anxiety and depressive symptoms, and fluctuations in ethnic identity predicted anxiety and depressive symptoms. CONCLUSION: Daily volatility in comfort with English, collectivist values, and ethnic identity appear to be most distressing.

Acculturation Trajectories Differ by Youth Age at Arrival and Time in Residency among Latino Immigrant Families in a US Emerging Immigrant Context.

The present study was designed to examine acculturation trajectories of first-generation, Latino immigrant youth and their parents in an emerging immigrant context. We also examined whether acculturation trajectories differed between families with youth who migrated at different stages of development and who have spent differential amounts of time in the United States (US). A community sample of 217 immigrant families in western Oregon was purposely sampled according to youths' age at arrival and time in US residency (TR) and assessed three times over a 3-year period. Families were stratified into three TR groups: TR1 = 2-4 years spent in the US; TR2 = 6-8 years spent in the US; and TR3 = 10-12 years. Parents and youth in each TR group completed measures assessing their acculturation to US American and Latino culture. Results from multiple-group latent growth models showed that acculturation trajectories differed for both youth and parents depending on the TR group. Moreover, both youth and their parents within each TR group differed in their acculturation trajectories. Overall, although youth slowly gravitated toward biculturalism over time, their parents remained relatively separated such that they reported high endorsement of their heritage culture and low endorsement of US culture over time. Findings are discussed in terms of prior research and theory.

Development and validation of a risk assessment tool for BKPyV Replication in allogeneic stem cell transplant recipients.

BACKGROUND: BK polymavirus (BKPyV), a member of the family Polyomaviridae, is associated with increased morbidity and mortality in allogeneic stem cell transplant recipients. METHODS: In our previous retrospective study of 2477 stem cell transplant patients, BKPyV replication independently predicted chronic kidney disease and poor survival. In this study, using the same cohort, we derived and validated a risk grading system to identify patients at risk of BKPyV replication after transplantation in a user-friendly modality. We used 3 baseline variables (conditioning regimen, HLA match status, and underlying cancer diagnosis) that significantly predicted BKPyV replication in our initial study in a subdistribution hazard model with death as a competing risk. We also developed a nomogram of the hazard model as a visual aid. The AUC of the ROC of the risk-score-only model was 0.65. We further stratified the patients on the basis of risk score into low-, moderate-, and high-risk groups. RESULTS: The total risk score was significantly associated with BKPyV replication (P < .0001). At 30 days after transplantation, the low-risk (score ≤ 0) patients had a 9% chance of developing symptomatic BKPyV replication, while the high-risk (score ≥ 8) of the population had 56% of developing BKPyV replication. We validated the risk score using a separate cohort of 1478 patients. The AUC of the ROC of the risk-score-only model was 0.59. Both the total risk score and 3-level risk variable were significantly associated with BKPyV replication in this cohort (P < .0001). CONCLUSIONS: This grading system for the risk of symptomatic BKPyV replication may help in early monitoring and intervention to prevent BKPyV-associated morbidity, mortality, and kidney function decline.

Preliminary Effects of Tailoring an Obesity Prevention Intervention Program for Latino Immigrant Families.

An obesity preventive intervention program for preschool families, Healthy Balance, was tested in 2 sequential pilot trials. The first pilot tested the original and translated group intervention in a heterogeneous population (65 families), and the second tested the feasibility of a culturally adapted version for Latinx immigrant families (27 families). No significant study 1 intervention effects were found. However, in study 2, there were significant improvements in parent body mass index, neck circumference, and blood pressure. These studies suggest that targeting family system change and tailoring the intervention for Latinx immigrant populations is feasible and has the potential to improve obesity-related biomarkers.

Cultural Adaptation of Promising, Evidence-Based, and Best Practices: a Scoping Literature Review.

This scoping literature review of nearly 5,000 peer-reviewed articles from myriad disciplines examines usage of two sets of terms that are common to many researchers, but arcane to many practitioners. Aiming to inform researchers about how scholarly literature that invokes these terms might speak to practitioners, and resulting implications for practice, we review scholarly use of three practice designations (promising, evidence-based, best) and five cultural considerations for those practices (adaptation, competence, modification, responsiveness, specificity). In addition to scoping review methods, we apply social cartography and definitional traces. Findings drive our contention that "promising practice" is the designation that might provide practitioners with the most utility, rather than the frequent-often-unarticulated-uses of best and evidence-based. Likewise, we find copious evidence of cultural considerations being invoked without operationalization. Social cartography reveals few international partnerships and limited domestic leadership among 'leading' research institutions regarding the intersection of practice designations and cultural considerations. Themes from the definitional trace prompt us to invite scholarly debate about a ladder from 'promising' to 'evidence-based' to 'best' and to prompt researchers' efforts to transfer knowledge to practitioners.

Outcomes from a Randomized Controlled Trial of the Relief Nursery Program.

An independent, randomized controlled trial of the community-developed, multiple-component Relief Nursery prevention program was conducted with families with young children considered "at risk" for child abuse and neglect. This established program, currently operating at multiple sites in the state of Oregon, comprises an integrated package of prevention services to children and families, including early childhood education, home visiting, and parent education and support, as well as other interventions tailored to the needs of each particular family. Families who contacted the Relief Nursery for the first time were randomly assigned to one of two conditions, the Full Program condition, whose members had access to all services available from the Relief Nursery, or the Respite Care condition, whose members had access only to respite care and referrals to services provided by other community agencies. A primary caregiver in each family was interviewed prior to intervention and then every 6 months across a period of 2 years. Standardized measures were collected on a variety of risk and protective factors related to child abuse and neglect. Analyses were conducted at the end of the study period. Differences were found between the conditions in terms of perceived helpfulness and satisfaction with services and in terms of social support, in each case favoring the Full Program condition. Implications of the findings for future studies of multicomponent child abuse prevention programs with similar characteristics to the Relief Nursery are discussed.

Associations among the advisory working alliance and research self-efficacy within a relational-efficacy framework.

Using a relational-efficacy framework, we examined the advisory working alliance and its associations with research self-efficacy among clinical and counseling psychology doctoral-level students. Moreover, we examined whether the association between the advisory working alliance was indirectly associated with research self-efficacy by way of relation-inferred self-efficacy (RISE; i.e., how advisees perceive their advisors view their research abilities). Next, we examined whether other-efficacy (i.e., how advisees view their advisors' research abilities) moderated the relationship between RISE and research self-efficacy. Last, to add confidence in our findings, we tested a theoretically plausible alternative model against our specified model to determine which might better fit the data. Doctoral-level students (N = 144) from American Psychological Association-accredited clinical and counseling psychology programs completed questionnaires measuring the advisory working alliance, RISE, other efficacy, and research self-efficacy. Results from mediation analysis found that the link between the advisory working alliance and research self-efficacy operated indirectly through RISE. Furthermore, other-efficacy moderated the relationship between RISE and research self-efficacy such that this relationship was stronger at higher levels of other efficacy. Finally, results indicated that the original specified model fit the data better than the alternative model. Taken together, findings suggest that advisory working alliance may transmit relationship-specific information to students that in turn fosters students' perceived research self-efficacy. However, the extent to which this relationship-specific information fosters research self-efficacy may depend in part on the extent to which students view their advisors as adept and competent researchers. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Alcohol use severity, depressive symptoms, and optimism among Hispanics: Examining the immigrant paradox in a serial mediation model.

OBJECTIVE: Hispanic immigrants exhibit more positive outcomes than U.S.-born Hispanics across educational, psychological, and physical health indices, a phenomenon called the immigrant paradox. We examined the immigrant paradox in relation to alcohol use severity among Hispanic young adults while considering both positive (optimism) and negative (depressive symptoms) processes. METHOD: Among 200 immigrant and U.S.-born Hispanic young adults (Mage = 21.30; 49% male) in Arizona and Florida, we tested whether optimism and depressive symptoms statistically mediated the relationship between nativity and alcohol use severity. Specifically, we examined whether Hispanic immigrants reported greater optimism than their U.S.-born counterparts, and whether such optimism was, in turn, associated with less depressive symptoms and thus lower alcohol use severity. RESULTS: Indirect effects were significant in hypothesized directions (nativity → optimism → depressive symptoms → alcohol use severity). CONCLUSIONS: Both positive and negative psychological processes are important to consider when accounting for the immigrant paradox vis-à-vis alcohol use severity among Hispanic young adults.

Latinx Immigrant Farmworker Community Health Promotion: A Needs Assessment.

The present study examined the health promotion intervention needs of Latinx immigrant farmworker families residing in Oregon. Grounded theory qualitative procedures were used to analyze the needs assessment data from 31 Latinx immigrant farmworker residents and key informant interviews as well as four focus groups with resident youth and parents. A theoretical model of how key family-based health behaviors can both confer risk for and protection against negative physical, mental, and social health outcomes among Latinx farmworking communities emerged. Six primary areas of concern emerged from these data, leading to the identification of primary health promotion intervention needs with three foci: (a) the provision of sustainable supports and resources, (b) skill development so that individuals could successfully negotiate identified challenges, and (c) greater community efficacy. Findings underscore the importance of social support and resource accessibility for Latinx immigrant populations.

Climbing the ladder of decline: Income and acculturation associated with chronic inflammation among Mexican immigrants.

OBJECTIVES: Financial hardship and immigrant status are often associated with poorer health as immigrant groups acculturate to life in the US. Known as the Latino health paradox, studies have shown that Latino/a immigrants in particular often experience declines in health the more they embrace ways of life considered "dominant" by US society. At present, critical biological pathways linking socioeconomic and acculturative processes remain to be better explained. The present study investigates associations among financial strain, acculturation, and chronic inflammation. METHODS: In our study of 129 Mexican-born immigrants living in the US, we used Pearson's correlations and multiple regression analyses to investigate links among income-to-poverty ratio (an indicator of financial strain), English language engagement (acculturation), and C-reactive protein (CRP), a measure of systemic inflammation. RESULTS: Results showed that for men, but not women, acculturation as defined by English language engagement moderated the association between an income-to-poverty ratio and CRP levels. CONCLUSIONS: Consistent with the Latino health paradox, more acculturated men with relatively higher income levels (compared with the study sample) had significantly higher levels of CRP.

Mind the Gap: Bridging the Divide Between Current Binge Drinking Prevention and the Needs of Hispanic Underage Emerging Adults.

In this article, we highlight the urgent public health need for prevention of heavy episodic drinking among underage Hispanic emerging adults in the USA. We outline the current state of binge drinking prevention programming and contrast it with the unique cultural, social, and developmental realities of this population using an ecodevelopmental framework (Szapocznik and Coatsworth 1999). Finally, we advance specific recommendations for the development and delivery of culturally tailored, multisystemic binge drinking prevention programs for underage Hispanic emerging adults.

Stem Cell Transplantation and Informatics: Current Considerations.

Informatics strategies and applications available to stem cell transplant (SCT) programs are diverse and changing rapidly. Although most hospitals have electronic medical records (EMRs), few are equipped with specialized SCT applications. Most EMRs do not contain critical elements to support SCT practice and research. Strategies to optimize information technology resources to support SCT programs are reviewed and technical and workflow support discussed. Guidance and rationale for the use of both SCT applications and EMRs are emphasized.

Longitudinal effects of acculturation and enculturation on mental health: Does the measure matter?

A great deal of research has focused on acculturation and enculturation, which represent the processes of adapting to a new culture. Despite this growing literature, results have produced inconsistent findings that may be attributable to differences in terms of the instruments used to assess acculturation and enculturation. Utilizing a 3-year longitudinal data set (with 1-year lags between assessments), the present study explored the psychometric properties of the Bicultural Involvement Questionnaire-Short Version (BIQ-S) and the Acculturation Rating Scale for Mexican Americans II (ARSMA-II) and examined the overlap between changes in these measures as they relate to internalizing and externalizing problem behavior. The present sample consisted of 216 immigrant Latino youth (43% boys; mean age 13.6 years at baseline; SD = 1.44 years, range 10 to 17). Exploratory structural equation modeling identified factor structures for the BIQ-S and ARSMA-II that diverged from their hypothesized structure. Growth curve models also indicate divergence between the BIQ-S and ARSMA-II in terms of change in acculturation and enculturation processes. Finally, the present findings emphasized that measures of acculturation and enculturation are not equivalent in terms of their effects on internalizing and externalizing problems.

The Histidine Residue of QseC Is Required for Canonical Signaling between QseB and PmrB in Uropathogenic Escherichia coli.

Two-component systems are prototypically comprised of a histidine kinase (sensor) and a response regulator (responder). The sensor kinases autophosphorylate at a conserved histidine residue, acting as a phosphodonor for subsequent phosphotransfer to and activation of a cognate response regulator. In rare cases, the histidine residue is also essential for response regulator dephosphorylation via a reverse-phosphotransfer reaction. In this work, we present an example of a kinase that relies on reverse phosphotransfer to catalyze the dephosphorylation of its cognate partner. The QseC sensor kinase is conserved across several Gram-negative pathogens; its interaction with its cognate partner QseB is critical for maintaining pathogenic potential. Here, we demonstrate that QseC-mediated dephosphorylation of QseB occurs via reverse phosphotransfer. In previous studies, we demonstrated that, in uropathogenic Escherichia coli, exposure to high concentrations of ferric iron (Fe3+) stimulates the PmrB sensor kinase. This stimulation, in turn, activates the cognate partner, PmrA, and noncognate QseB to enhance tolerance to polymyxin B. We demonstrate that in the absence of signal, kinase-inactive QseC variants, in which the H246 residue was changed to alanine (A) aspartate (D) or leucine (L), rescued a ΔqseC deletion mutant, suggesting that QseC can control QseB activation via a mechanism that is independent of reverse phosphotransfer. However, in the presence of Fe3+, the same QseC variants were unable to mediate a wild-type stimulus response, indicating that QseC-mediated dephosphorylation is required for maintaining proper QseB-PmrB-PmrA interactions.IMPORTANCE Two-component signaling networks constitute one of the predominant methods by which bacteria sense and respond to their changing environments. Two-component systems allow bacteria to thrive and survive in a number of different environments, including within a human host. Uropathogenic Escherichia coli, the causative agent of urinary tract infections, rely on two interacting two-component systems, QseBC and PmrAB, to induce intrinsic resistance to the colistin antibiotic polymyxin B, which is a last line of defense drug. The presence of one sensor kinase, QseC, is required to regulate the interaction between the other sensor kinase, PmrB and the response regulators from both systems, QseB and PmrA, effectively creating a "four-component" system required for virulence. Understanding the important role of the sensor kinase QseC will provide insight into additional ways to therapeutically target uropathogens that harbor these signaling systems.