RESUMO
Half of the myelodysplastic syndromes (MDS) have normal karyotype by conventional banding analysis. The percentage of true normal karyotype cases can be reduced by 20-30% with the complementary application of genomic microarrays. We here present a multicenter collaborative study of 163 MDS cases with a normal karyotype (≥10 metaphases) at diagnosis. All cases were analyzed with the ThermoFisher® microarray (either SNP 6.0 or CytoScan HD) for the identification of both copy number alteration(CNA) and regions of homozygosity (ROH). Our series supports that 25 Mb cut-off as having the most prognostic impact, even after adjustment by IPSS-R. This study highlights the importance of microarrays in MDS patients, to detect CNAs and especially to detect acquired ROH which has demonstrated a high prognostic impact.
RESUMO
We present a review of 28 cases of intrauterine device (IUD) users who asked for permanent contraception with Essure procedure and accepted concomitant use of IUD and Essure. We ultimately achieved correct bilateral placement in 26 women (92.8%). In 8 cases (28.6%), it was necessary to remove the IUD to try and place the device. Our results suggest hysteroscopic tubal sterilization with Essure microinserts in IUD users is feasible, safe, and reliable. Moreover, there is no need to instruct the patients to use another form of birth control until 3 months postprocedure. We think this application could be a good alternative approach for a high percentage of IUD users who request a permanent hysteroscopic sterilization.