Decreases in organ blood flows associated with increases in sublingual PCO2 during hemorrhagic shock.

Earlier studies demonstrated that not only the stomach but also the esophageal wall served as an appropriate site for estimating the severity of circulatory shock by using tonometric methods. We then conceived of the option of sublingual tonometry. In the present study, we tested the hypothesis that the changes in sublingual PCO2 serve as indicators of decreases in blood flow to sublingual and visceral tissue. In Sprague-Dawley rats, sublingual PCO2 increased from 50 to 127 Torr and arterial blood lactate increased from 0.9 to 11.2 mmol/l during bleeding. Sublingual blood flow simultaneously decreased to approximately 32% of preshock values. After reinfusion of shed blood, organ blood flows and sublingual PCO2 were promptly restored to near-baseline values. There were corresponding decreases in blood flows in the tongue, stomach, jejunum, colon, and kidneys during hemorrhagic shock. Increases in sublingual PCO2 were highly correlated with decreases in sublingual blood flow (r = 0.80), tongue blood flow (r = 0.81), gastric blood flow (r = 0.74), jejunal blood flow (r = 0.65), colon blood flow (r = 0.80), and renal blood flow (r = 0.75). Unbled control animals demonstrated no significant changes. Therefore, we anticipate that sublingual tonometry will provide a useful, noninvasive alternative for monitoring visceral PCO2.

Peripheral skeletal tuberculosis of the foot. Etiologic review and case study.

Mycobacterium tuberculosis is a disease that is being reported much more frequently in the literature, primarily because of the rapid increase in severely immunocompromised patients, but also because of the development of multiple drug-resistant tuberculosis strains. Extrapulmonary M. tuberculosis is also reportedly on the rise, and may manifest itself at a number of sites in the body, including the peripheral skeleton. It is important to recognize peripheral tuberculosis osteomyelitis early because early treatment can effectively eliminate long-term morbidity. The authors present a review of the diagnosis and treatment of extrapulmonary M. tuberculosis, with special emphasis on peripheral skeletal tuberculous osteomyelitis. A case study involving peripheral skeletal tuberculous osteomyelitis in the foot is presented.

Observation of two distinct phase states in a self-phase-locked type II phase-matched optical parametric oscillator.

We demonstrate self-phase locking in a type II phase-matched optical parametric oscillator by mutual injection locking. An intracavity quarter-wave plate provides polarization mixing between the orthogonally polarized signal and idler that induces signal-idler self-phase locking when their frequency difference is within the capture range. We observed two distinct phase states that differ in their oscillator thresholds and their signal-idler phase differences, in good agreement with theory.

The logical structure and validity of experimental designs in pharmacokinetics and clinical pharmacology.

Much of the literature on research design in clinical pharmacology and pharmacokinetics emphasizes statistical concerns, thus suggesting that a primary ingredient of a valid research design is an appropriate plan for statistical analysis of data. However, statistical validity is only one of several ways to evaluate an experimental study. The present paper reviews the underlying logic and sources of invalidity of experimental drug research suggesting influences and factors which may deceive or lure an experimenter into erroneous conclusions.

Periodically poled BaMgF(4) for ultraviolet frequency generation.

Ferroelectric domain inversion has been demonstrated in BaMgF(4) . Transparency has been measured to <140nm, and no change in transmission was measured under 157-nm irradiation for >1.1x10(9) shots at 2mJ/cm(2) per pulse. First-order quasi-phase-matched generation of 157 nm is predicted by use of grating periods as long as 1.5mum. This material should permit shorter-wavelength chi((2)) frequency-mixing processes than with any other crystalline material.