Detalhe da pesquisa
1.
Targeting Mitosis in Cancer: Emerging Strategies.
Mol Cell
; 60(4): 524-36, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26590712
2.
Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.
Proc Natl Acad Sci U S A
; 114(12): 3127-3132, 2017 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28270606
3.
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.
Genes Dev
; 25(10): 1041-51, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21576264
4.
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.
Bioorg Med Chem Lett
; 26(15): 3562-6, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27335255
5.
Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.
Bioorg Med Chem Lett
; 26(19): 4625-4630, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27592744
6.
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Bioorg Med Chem
; 22(17): 4968-97, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043312
7.
Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms.
Leukemia
; 38(3): 502-512, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38114624
8.
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.
Trends Cell Biol
; 16(1): 45-54, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337795
9.
Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop.
Mol Biol Cell
; 15(5): 2176-88, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15004239
10.
Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.
Oncotarget
; 8(2): 3064-3071, 2017 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27902970
11.
Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.
ACS Med Chem Lett
; 7(7): 671-5, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437075
12.
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
J Med Chem
; 58(1): 130-46, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24867403
13.
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.
J Med Chem
; 58(1): 147-69, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25723005
14.
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.
Cancer Cell
; 27(2): 211-22, 2015 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25620030
15.
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.
J Med Chem
; 58(8): 3366-92, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25763473
16.
Review of enoxaparin and its clinical applications in venous and arterial thromboembolism.
Expert Opin Pharmacother
; 3(5): 575-98, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11996636
17.
Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210.
J Negat Results Biomed
; 3: 7, 2004 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15613247
18.
Organization of vagal afferents in pylorus: mechanoreceptors arrayed for high sensitivity and fine spatial resolution?
Auton Neurosci
; 183: 36-48, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656895
19.
Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.
Cancer Cell
; 26(2): 163-76, 2014 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043604
20.
Vagal afferent innervation of the lower esophageal sphincter.
Auton Neurosci
; 177(2): 129-42, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583280