Detalhe da pesquisa
1.
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Mol Cell
; 78(6): 1152-1165.e8, 2020 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32516598
2.
Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene.
Respir Res
; 13: 92, 2012 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23061798
3.
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
J Med Chem
; 65(19): 13198-13215, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126059
4.
The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.
Bioorg Med Chem Lett
; 21(2): 734-7, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21208803
5.
A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Bioorg Med Chem Lett
; 21(1): 484-7, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126875
6.
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Bioorg Med Chem Lett
; 21(3): 1041-6, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21215624
7.
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
Bioorg Med Chem Lett
; 20(12): 3760-3, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20471829
8.
Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Bioorg Med Chem Lett
; 19(8): 2125-8, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19307115
9.
Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Am J Respir Cell Mol Biol
; 39(1): 26-35, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18258919
10.
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
J Pharmacol Exp Ther
; 325(2): 425-34, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287210
11.
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.
Bioorg Med Chem Lett
; 18(8): 2696-700, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18359630
12.
Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Bioorg Med Chem Lett
; 18(6): 2048-54, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291643
13.
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
J Med Chem
; 50(4): 794-806, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17300164
14.
The C3a receptor antagonist SB 290157 has agonist activity.
Immunol Lett
; 100(2): 139-45, 2005 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16154494
15.
The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
J Med Chem
; 53(5): 2227-38, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20163116
16.
Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Eur J Immunol
; 38(7): 1900-12, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18506884
17.
Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.
J Pharmacol Exp Ther
; 319(3): 1043-50, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16973887
18.
Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.
J Biol Chem
; 281(34): 24704-12, 2006 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16790440
19.
Identification of an indole series of prostaglandin D2 receptor antagonists.
Bioorg Med Chem Lett
; 16(11): 3043-8, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16529930
20.
Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
Bioorg Med Chem Lett
; 13(6): 1129-32, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643927