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1.
J Craniofac Surg ; 30(4): e312-e315, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31166276

RESUMO

Interpersonal violence is a major cause of maxillofacial fractures. The aim of this study was to analyze the characteristics of these fractures associated in an effort to develop more effective management. The clinical records and radiographs of 272 patients with maxillofacial fractures associated with interpersonal violence collected during a 36-year period were retrospectively analyzed. Two hundred and nineteen patients were male (80.5%) and 53 (19.5%) were female. The patients ranged in age from 1 to 77 years. Two hundred and two patients (74.3%) were aged 10 to 29 years. The injury was the result of impact by a fist/hand/elbow in 224 patients (82.3%). The fracture site was the mandible in 191 patients (70.2%), the midface in 78 (28.7%), and both sites in 3 (1.1%). One hundred and eight (39.6%) of 273 mandibular fractures were in the angle, 75 (27.5%) were in the symphysis, and 90 (33.0%) were at other sites. Forty-three (53.1%) of 81 fractures in the midface were in the zygoma, 19 (23.5%) were in the maxilla, and 19 (23.5%) were at other sites. Fractures were more common on the left side. Nine patients (3.3%) also had injuries at other body sites. Ninety-five patients (34.9%) were treated by maxillomandibular fixation, 84 (30.9%) by open reduction and internal fixation, 59 (21.7%) by observation, 14 (5.1%) by intramaxillary splinting, 14 (5.1%) by transcutaneous reduction, and 6 (2.2%) by other procedures. Interpersonal violence-related maxillofacial fractures have characteristic features, especially with regard to site and laterality.


Assuntos
Traumatismos Faciais/cirurgia , Fraturas Cranianas/cirurgia , Violência , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Fixação Interna de Fraturas/métodos , Humanos , Lactente , Técnicas de Fixação da Arcada Osseodentária , Masculino , Mandíbula/cirurgia , Fraturas Mandibulares/cirurgia , Fraturas Maxilares/cirurgia , Pessoa de Meia-Idade , Redução Aberta/efeitos adversos , Procedimentos de Cirurgia Plástica/efeitos adversos , Estudos Retrospectivos , Adulto Jovem
2.
Dent Traumatol ; 34(3): 151-157, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29526035

RESUMO

BACKGROUND/AIM: Sports activity increases the risk of maxillofacial fractures. The aim of this study was to analyze trends and characteristics of maxillofacial fractures sustained during sports activity to develop more effective treatments and possibly to prevent injury. MATERIALS AND METHODS: Data of 248 patients with maxillofacial fractures sustained during sports activity were retrospectively analyzed based on their clinical records and radiographs. RESULTS: The patients were 226 males (91.1%) and 22 females (8.9%). Their ages ranged from 6 to 70 years and the majority were in their second decade. The fractures were sustained in various sports which included baseball in 85 patients (34.3%), rugby in 40 (16.1%), soccer in 30 (12.1%), softball in 22 (8.9%), golf in 10 (4.0%), hockey in 8 (3.2%), combat sports in 28 (11.3%), and others in 29 (11.7%). The cause of injuries was collision with another player in 97 patients (39.1%), hit by a ball in 89 (35.9%), intended attack in 20 (8.1%), hit by equipment of another player in 15 (6.0%), a fall in 14 (5.6%), and collision with ground equipment in 13 (5.2%). The site of fractures was the mandible in 145 patients (58.5%), midface in 100 (40.3%), and both in 3 (1.2%). Among 210 fracture sites in the mandible, 77 (36.6%) were in the angle, 68 (32.4%) in the symphysis, and 65 (30.9%) in others. Among 103 fractures in the midface, 58 (56.3%) were in the zygoma, 26 (25.2%) in alveolar bone, and 19 (18.4%) in others. Treatment was observation in 67 patients (27.0%), maxillomandibular fixation in 64 (25.8%), open reduction and internal fixation in 63 (25.4%), intramaxillary splinting in 40 (16.1%), transcutaneous reduction in 10 (4.0%), and other procedures in 4 (1.6%). CONCLUSION: Maxillofacial fractures sustained during sports activity showed characteristic features dependent on the type of sport and cause of injury.


Assuntos
Traumatismos em Atletas/epidemiologia , Traumatismos em Atletas/terapia , Traumatismos Maxilofaciais/epidemiologia , Traumatismos Maxilofaciais/terapia , Fraturas Cranianas/epidemiologia , Fraturas Cranianas/terapia , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
3.
J Oral Maxillofac Surg ; 75(6): 1239.e1-1239.e11, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28325640

RESUMO

PURPOSE: This study was performed to evaluate stresses in various types of plates placed for a virtually reduced unilateral condylar fracture of the mandible using computed tomography-based 3-dimensional finite element (FE) models of a patient to select the optimal plate system. MATERIALS AND METHODS: A computed tomography-based FE model of the mandible of a patient with a unilateral condylar fracture was constructed. The fracture was virtually reduced and fixed with 1 straight titanium plate; 2 straight titanium plates; 2 straight poly-L-lactic acid plates; and 4-hole (box), 5-hole (strut), and 7-hole (lambda) condylar plates. Stresses developing in these plates were analyzed by applying 478.1 N of bite force at the first molar of the contralateral side of the mandible. RESULTS: The magnitudes of tensile stress were within the tensile strength in all types of plates. However, the magnitudes of compressive stress in 1 straight titanium plate and 2 straight poly-L-lactic acid plates were beyond the compressive strength. The tensile and compressive stresses of the 5-hole (strut) plate were the smallest among the 3 types of condylar plates. CONCLUSIONS: Fixation by 2 straight titanium plates or any type of condylar plate was biomechanically indicated for the condylar fracture of this patient. Among these plates, the 5-hole (strut) plate was considered optimal. FE analysis is useful in selecting the optimal fixation method in the individual patient.


Assuntos
Placas Ósseas , Imageamento Tridimensional/métodos , Côndilo Mandibular/lesões , Fraturas Mandibulares/cirurgia , Tomografia Computadorizada por Raios X/métodos , Implantes Absorvíveis , Força Compressiva , Feminino , Análise de Elementos Finitos , Humanos , Pessoa de Meia-Idade , Poliésteres , Cirurgia Assistida por Computador , Resistência à Tração , Titânio
4.
J Craniofac Surg ; 24(1): 153-7, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23348275

RESUMO

Maxillofacial fractures in Japanese children were retrospectively analyzed. The subjects were 287 patients aged 15 years and younger seeking treatment for maxillofacial fractures in the Department of Oral and Maxillofacial Surgery, Nara Medical University. The patients were 186 males and 101 females. Injuries most frequently occurred as a result of traffic accidents in 125 patients, 92 of which were bicycle-related accidents. Injuries by falling from one level to another were found in 49, primarily in younger children. One hundred seventy-nine fractures occurred in the mandible, 100 in the midface, and 8 in both. In the mandible, fractures most frequently occurred in condyle followed by symphysis. In the midface, alveolus was mostly involved. The facial injury severity scale ranged from 1 to 9 with an average of 1.83 and was higher in traffic accidents. Injury to other sites of the body was found in 33 patients, 28 of which occurred in traffic accidents. Observation was most frequently chosen in 84 patients. Intramaxillary fixation was chosen in 79, primarily for alveolar fractures and in younger children. Maxillomandibular fixation was chosen in 62 for mandibular fractures in older children. Open reduction and internal fixation was performed in 40, primarily in older children. The facial injury severity scale was higher in patients treated by open reduction and internal fixation and maxillomandibular fixation. Maxillofacial fractures in Japanese children showed characteristic features primarily depending on their age in terms of etiology, patterns, and treatment modalities.


Assuntos
Ossos Faciais/lesões , Fixação Interna de Fraturas/métodos , Fraturas Cranianas/cirurgia , Adolescente , Criança , Pré-Escolar , Feminino , Consolidação da Fratura , Humanos , Lactente , Recém-Nascido , Escala de Gravidade do Ferimento , Japão/epidemiologia , Masculino , Fatores de Risco , Fraturas Cranianas/epidemiologia , Fraturas Cranianas/etiologia , Resultado do Tratamento
5.
BMJ Open ; 13(8): e074279, 2023 08 16.
Artigo em Inglês | MEDLINE | ID: mdl-37586860

RESUMO

INTRODUCTION: Oral lichen planus (OLP) is a chronic, inflammatory oral condition leading to a range of symptoms from mild discomfort to severe pain, affecting patients' quality of life. Standard therapy involves the use of topical corticosteroids, although some patients respond insufficiently or develop resistance to therapy. We aim to explore if adding cepharanthine, an herbal extract from Stephania cepharantha Hayata, can enhance the efficacy of corticosteroid therapy in symptomatic OLP. METHODS AND ANALYSIS: This open-label, parallel-group, multi-centre, randomised controlled study will be conducted at three Japanese hospitals. It will compare safety and efficacy of integrated oral cepharanthine and corticosteroid therapy versus standard corticosteroid therapy. 50 symptomatic OLP patients will be randomised 1:1 to receive cepharanthine (30 mg/day) plus topical dexamethasone, or topical dexamethasone alone for 8 weeks. The primary outcome will be changed in pain intensity while drinking room-temperature water, measured on a visual analogue scale. The primary outcome is the change in pain intensity from baseline when drinking room-temperature water, evaluated using a visual analogue scale. Secondary outcomes are changes in the longest diameter of the target lesion from baseline to weeks 4 and 8, improvement and deterioration rates according to appearance and severity criteria at weeks 4 and 8, change in pain intensity when drinking room-temperature water from baseline to week 4, changes in pain intensity at rest from baseline to weeks 4 and 8, and the rates of adverse events. ETHICS AND DISSEMINATION: This protocol was approved by the Certified Review Board of Nara Medical University (CRB5200002). Participants will provide informed consent. Results will be disseminated in peer-reviewed journals and conferences. TRIAL REGISTRATION NUMBER: Japan Registry of Clinical Trials (jRCTs051220130).


Assuntos
Fármacos Dermatológicos , Líquen Plano Bucal , Humanos , Líquen Plano Bucal/tratamento farmacológico , Qualidade de Vida , Dexametasona , Água , Ensaios Clínicos Controlados Aleatórios como Assunto , Estudos Multicêntricos como Assunto
6.
J Oral Maxillofac Surg ; 69(6): e147-51, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21444138

RESUMO

PURPOSE: The purpose of this study was to analyze impalement injuries of the oral cavity in children. PATIENTS AND METHODS: Data on 144 children with impalement injuries in the oral cavity at the Department of Oral and Maxillofacial Surgery, Nara Medical University were analyzed retrospectively. RESULTS: The patients were 93 boys and 51 girls (age range, 7 months to 10 years). One hundred thirty-two patients (91.7%) were younger than 5 years. Injuries occurred frequently by falling onto an object held in the mouth in 77 patients (53.5%). The impaled objects were a toothbrush in 30 patients (20.8%), a cylindrical toy in 27 (18.8%), and chopsticks in 19 (13.2%). The soft palate was frequently involved in 64 patients (44.4%), followed by the hard palate in 26 (18.1%). Computed tomographic examination was performed in 16 patients (11.1%). Observation with or without medication was most frequently chosen in 98 patients (68.1%). Surgical intervention was performed in 46 patients (31.9%), 41 under local anesthesia and 5 under general anesthesia. Admission was required in 12 patients (8.3%). No complications, such as deep infection or neurologic sequelae, were observed. CONCLUSIONS: Most impalement injuries in the oral cavity in children heal spontaneously or with minimal intervention. These children can be followed on an outpatient basis with instructions to their parents about possible complications, except for a few selected cases.


Assuntos
Boca/lesões , Ferimentos Penetrantes/terapia , Acidentes , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Palato Duro/lesões , Palato Mole/lesões , Ferimentos Penetrantes/patologia
7.
J Oral Maxillofac Surg ; 69(8): 2204-10, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21683497

RESUMO

PURPOSE: The purpose of the present study was to analyze the trends and characteristic features of maxillofacial fractures in older patients. PATIENTS AND METHODS: The data from 247 patients aged 65 years old or older, who were treated for maxillofacial fractures at the Department of Oral and Maxillofacial Surgery, Nara Medical University, from October 1981 to March 2010, were retrospectively analyzed. RESULTS: Of the 247 patients, 127 were men and 120 were women; 50 patients had been treated in the first third of the period, 87 in the second, and 110 in the third. Injury had most frequently occurred because of falling on a level surface (n = 126), followed by a traffic accident (n = 84). Of the fractures, 140 were in the mandible, 90 in the midface, and 17 in both. In the mandible, the fracture lines were most frequently observed at the condyle, followed by the body, exclusively in edentulous patients. In the midface, the zygoma was mostly involved. The facial injury severity scale score ranged from 1 to 10 (average 1.81). Injury at other sites of the body was found in 45 patients. Observation was most frequently chosen (n = 127), primarily for those of older age, followed by open reduction and internal fixation in 46 and maxillomandibular fixation in 41 patients. The facial injury severity scale score was greatest in patients treated by open reduction and internal fixation, followed by those treated by maxillomandibular fixation. CONCLUSION: Maxillofacial fractures in older patients have been increasing and showed the characteristic features of etiology, patterns, and treatment modalities.


Assuntos
Traumatismos Maxilofaciais/epidemiologia , Fraturas Cranianas/epidemiologia , Acidentes por Quedas/estatística & dados numéricos , Acidentes de Trânsito/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Feminino , Fixação Interna de Fraturas/estatística & dados numéricos , Humanos , Escala de Gravidade do Ferimento , Japão/epidemiologia , Técnicas de Fixação da Arcada Osseodentária/estatística & dados numéricos , Arcada Edêntula/epidemiologia , Masculino , Côndilo Mandibular/lesões , Fraturas Mandibulares/epidemiologia , Fraturas Maxilares/epidemiologia , Estudos Retrospectivos , Conduta Expectante/estatística & dados numéricos , Fraturas Zigomáticas/epidemiologia
8.
J Oral Maxillofac Surg ; 69(6): e155-60, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21496994

RESUMO

PURPOSE: The purpose of this study was to analyze maxillofacial fractures sustained in bicycle accidents by demographics, cause of injury, site and severity of fractures, injuries to other sites of the body, and treatment modalities. PATIENTS AND METHODS: Data on 307 patients treated for maxillofacial fractures sustained in bicycle accidents in the Department of Oral and Maxillofacial Surgery, Nara Medical University from 1981 through 2009 were analyzed retrospectively. RESULTS: The patients were 166 males and 141 females (average age, 30.9 years). Causes of injury were a fall on a level surface in 169 patients, an automobile accident in 56, fall from 1 level to another in 28, and a motorcycle accident in 24. One hundred seventy-five fractures were observed in the mandible, 117 in the midface, and 15 in the mandible and midface. In the mandible, fracture lines were exclusively observed at the condyle. In the midface, the zygoma was most frequently involved. The Facial Injury Severity Scale ranged from 1 to 7 (average, 1.88). Injuries at other sites of the body were found in 47 patients and were frequently found in automobile and motorcycle accidents. Maxillomandibular fixation was most frequently chosen in 81 patients, followed by observation in 76 and open reduction and internal fixation in 71. The Facial Injury Severity Scale was highest in patients treated by open reduction and internal fixation, followed by those treated by maxillomandibular fixation. CONCLUSIONS: Maxillofacial fractures sustained in a bicycle accident frequently occurred by falling on a level surface and were not so serious in most cases; however, in accidents with motor vehicles, injuries to other sites of the body were observed at a higher rate.


Assuntos
Ciclismo/lesões , Fraturas Ósseas/terapia , Traumatismos Maxilofaciais/terapia , Acidentes por Quedas , Acidentes de Trânsito , Adolescente , Adulto , Idoso , Criança , Feminino , Fixação de Fratura/métodos , Fraturas Ósseas/patologia , Humanos , Masculino , Fraturas Mandibulares/patologia , Fraturas Mandibulares/terapia , Traumatismos Maxilofaciais/patologia , Pessoa de Meia-Idade , Adulto Jovem
9.
Dent Traumatol ; 27(4): 318-20, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21535403

RESUMO

A mandibular body fracture related to mouth-opening training in a dialysis patient is reported. A 61-year-old male patient had noticed pain in the right mandibular body and difficulty in mouth opening a week previously. The patient had been performing mouth-opening training for a couple of weeks. The right lower face was slightly swollen with tenderness at the right lower border of the mandible. Hypoesthesia of the right lower lip was also observed. A bone step was palpable on the alveolar ridge of the right mandible, but mobility was not marked. The mandible was atrophic in the body region with only four anterior teeth left. Panoramic X-ray examination revealed a moderately displaced fracture in the right molar region of the mandible. The patient had no severe pain or difficulty in eating using a partial denture. The patient had received dialysis for 17 years and had also been treated by warfarin and aspirin. The patient was followed up under restricted mouth opening. Osteosynthesis with bone remodeling was confirmed after 6 months by X-ray examination. No complication requiring further treatment occurred during the follow-up period. In this patient, a medically compromised condition under long-term dialysis is considered a predisposing factor, which made the atrophic mandible more susceptible to the stress related to mouth-opening training.


Assuntos
Fraturas Mandibulares/etiologia , Exercícios de Alongamento Muscular/efeitos adversos , Diálise Renal/efeitos adversos , Perda do Osso Alveolar/complicações , Humanos , Masculino , Fraturas Mandibulares/fisiopatologia , Pessoa de Meia-Idade , Amplitude de Movimento Articular , Transtornos da Articulação Temporomandibular/complicações , Transtornos da Articulação Temporomandibular/terapia
10.
Case Rep Dent ; 2021: 5927215, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34931148

RESUMO

Here, we report a case of synovial chondromatosis of the temporomandibular joint (TMJ) with numerous loose bodies. A 56-year-old woman was examined in the oral surgery department for trismus and pain in the left TMJ when opening the mouth. Imaging indicated TMJ synovial chondromatosis, and the patient was referred to our department for further examination. Her facial features were symmetrical, and no occlusal abnormalities were found. The maximum mouth opening was 30 mm, and movement of the left mandibular condyle was restricted and accompanied by pain and joint sounds. Panoramic radiography showed deformation of the left mandibular condyle and radiopaque lesions surrounding it. Computed tomography showed numerous small granules around the left mandibular condyle, some of which were calcified. Magnetic resonance imaging showed anterior disc displacement without reduction in the left TMJ and hypointense lesions on T2-weighted images. Bone scintigraphy showed an accumulation in the area of the left TMJ. Based on the diagnosis of the left TMJ synovial chondromatosis, the lesions were removed, and plastic surgery on the mandibular condyle was performed under general anesthesia. We removed 386 white loose bodies. Histopathologically, the loose bodies were consistent with synovial chondromatosis lesions. The postoperative course was uneventful, with no recurrence or TMJ dysfunction approximately 5 years after the surgery, indicating that open surgery is the best course of intervention in such cases.

11.
J Oral Maxillofac Surg ; 68(7): 1602-7, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20417013

RESUMO

PURPOSE: The purpose of this study was to analyze maxillofacial fractures resulting from falls in terms of the demographics, the circumstance of injury, the site and severity of fracture, and the treatment. PATIENTS AND METHODS: Data of 457 patients treated for fall-related maxillofacial fractures at the Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan, from 1981 to 2007 were retrospectively analyzed. RESULTS: Patients were 163 males and 116 females with an average age of 51.3 years who had fallen on a level surface (simple fall), and 110 males and 68 females with an average age of 31.9 years in falls from a greater height (fall from height), respectively. Fractures of the mandible were more frequently observed than those of the midface. In the mandible, fracture lines were exclusively observed at the condyle, especially in simple falls. In the midface, the zygoma was most frequently involved. Facial Injury Severity Scale ranged from 1 to 6, with an average of 1.78 in simple falls, and from 1 to 9, with an average of 2.04 in falls from height, respectively. These were dependent on the causes and height of the fall. Fractures at the other sites of the body were found in 14 patients (5.0%) with simple falls and 38 (21.3%) with falls from height. Maxillomandibular fixation was most frequently chosen for mandibular fractures and observation for midface fractures. Open reduction and fixation was more frequently chosen in patients with falls from height than those with simple falls and in patients with a higher Facial Injury Severity Scale score. CONCLUSIONS: Maxillofacial fractures resulting from falls showed characteristic features in the demographics, the circumstance of injury, and the site and severity of fracture. Treatment was chosen according to these features.


Assuntos
Acidentes por Quedas/estatística & dados numéricos , Traumatismos Maxilofaciais/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Japão/epidemiologia , Estudos Longitudinais , Masculino , Traumatismos Maxilofaciais/classificação , Pessoa de Meia-Idade , Estudos Retrospectivos , Índice de Gravidade de Doença , Distribuição por Sexo , Adulto Jovem
12.
Dent Traumatol ; 26(4): 353-6, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20406280

RESUMO

The fate of developing tooth buds located in relation to mandibular fractures was investigated in three infancy cases. Three infants, 2 girls and a boy, aged from 1 year and 5-months old to 2 years and 6-months old, were treated for dislocated mandibular fracture in the symphyseal region by manual reduction and fixation with a thermoforming splint and circumferential wiring under general anesthesia. Fracture healing was uneventful in all cases. A few years later, no obvious deformity of the jaw or malocclusion was observed; however, malformation of the crown was found in one of the permanent teeth on the fracture line in the first case. In the second case, no abnormality was observed in one of the permanent teeth on the fracture line, but the effect on the other tooth could not be evaluated due to abnormality of the tooth probably not related to the injury. In the third case, root formation was arrested in one of the permanent teeth on the fracture line and the tooth was lost early after eruption. The development of tooth buds on the fracture line is not predictable and therefore, should be monitored by regular follow up.


Assuntos
Fraturas Mandibulares/terapia , Odontogênese/fisiologia , Germe de Dente/crescimento & desenvolvimento , Fios Ortopédicos , Pré-Escolar , Dente Canino/anormalidades , Feminino , Seguimentos , Consolidação da Fratura/fisiologia , Dentes Fusionados/etiologia , Humanos , Incisivo/anormalidades , Lactente , Luxações Articulares/fisiopatologia , Luxações Articulares/terapia , Masculino , Fraturas Mandibulares/fisiopatologia , Contenções , Coroa do Dente/anormalidades , Raiz Dentária/anormalidades , Dente Decíduo/anormalidades
13.
Masui ; 59(5): 597-603, 2010 May.
Artigo em Japonês | MEDLINE | ID: mdl-20486571

RESUMO

BACKGROUND: It is generally recognized that dental injury during general anesthesia is an important problem. We retrospectively evaluated the profiles of dental injuries during general anesthesia and associated factors for the development of dental injury. METHODS: From January 1999 to December 2008, all medical records of the patients with dental injury during general anesthesia were reviewed. RESULTS: Of 30,845 patients who underwent general anesthesia in the period, the dental injury developed in 110 patients (0.36%) during general anesthesia. The incidence of dental injury was higher in patients above 60 years of age, The patients who had received mouth guards had significantly lower incidence of dental injury compared with those without mouth guards (0.06% vs. 0.37%, P < 0.05). The left upper incisors were involved most commonly in the development of dental injury, and the timing of dental injury was most frequent at the time of tracheal intubation.


Assuntos
Anestesia Geral/efeitos adversos , Traumatismos Dentários/etiologia , Traumatismos Dentários/prevenção & controle , Adulto , Fatores Etários , Feminino , Humanos , Intubação Intratraqueal/efeitos adversos , Masculino , Pessoa de Meia-Idade , Protetores Bucais , Estudos Retrospectivos , Traumatismos Dentários/epidemiologia
14.
J Dent (Shiraz) ; 19(2): 159-163, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29854891

RESUMO

Immune thrombocytopenic purpura (ITP) is an immune-mediated acquired disease found in both adults and children. It is characterized by transient or persistent decreases in the platelet count. We report a case of ITP detected based on oral hemorrhagic symptoms. The patient was a 79-year-old female with no significant past medical history. She presented with sudden onset of gingival bleeding and hemorrhagic bullae on the buccal mucosa. Gingival bleeding was difficult to control. Laboratory tests revealed severe thrombocytopenia with a platelet count as low as 2000/µL. Under a provisional diagnosis of a hematological disorder, she was referred to a hematologist. A peripheral smear showed normal-sized platelets. A bone marrow examination revealed increased numbers of megakaryocytes without morphologic abnormalities. The patient was diagnosed with ITP and treated with a combination of pulsed steroid therapy and high-dose immunoglobulin therapy. However, her severe thrombocytopenia was refractory to these treatments. Then, a thrombopoietin receptor agonist was begun as a second-line treatment. Her platelets rapidly increased, and no bleeding complications were reported. Because oral symptoms can be one of the initial manifestations of ITP, dentists should be familiar with the clinical appearance of ITP, and attention must be paid to detect and diagnose unidentified cases.

15.
Case Rep Dent ; 2017: 7902978, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28409038

RESUMO

A foreign body granuloma of the buccal mucosa induced by honeybee sting was reported. The patient was an 82-year-old female who presented with a submucous mass at the right buccal mucosa. The mass was 20 mm in diameter, elastically firm, partly mobile without pain or tenderness, and covered with almost normal mucosa. MR image did not delineate the lesion clearly. Under clinical diagnosis of a benign tumor, the lesion was excised under local anesthesia. The excised lesion was 14 × 11 × 9 mm in size and solid and yellowish in cut surface. Histologically, the lesion consisted of granulomatous tissue with a few narrow, curved, eosinophilic structures compatible with decomposed fragments of a honeybee sting and was diagnosed as a foreign body granuloma, although the patient did not recall being stung.

16.
BMJ Open ; 7(8): e015952, 2017 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-28827248

RESUMO

OBJECTIVE: The effect of direct oral anticoagulants (DOACs) on the risk of bleeding after tooth extraction remains unclear. This study aimed to evaluate the incidence of postextraction bleeding among patients who received DOAC and vitamin K antagonists (VKAs), such as warfarin. DESIGN: This study was a retrospective cohort analysis. Incidence rates and propensity score-matched regression models were used to compare the risks of bleeding after tooth extractions involving DOACs and VKAs. SETTING: The study took place in a single university hospital in Japan. PARTICIPANTS: Between April 2013 and April 2015, 543 patients underwent a total of 1196 simple tooth extractions. PRIMARY OUTCOME MEASURE: The primary outcome measure was the occurrence of postextraction bleeding, which was defined as bleeding that could not be stopped by biting down on gauze and required medical treatment between 30 min and 7 days after the extraction. RESULTS: A total of 1196 tooth extractions (634 procedures) in 541 patients fulfilled the study criteria, with 72 extractions (41 procedures) involving DOACs, 100 extractions (50 procedures) involving VKAs and 1024 extractions (543 procedures) involving no anticoagulants. The incidences of postextraction bleeding per tooth for the DOAC, VKA and no anticoagulant extractions were 10.4%, 12.0% and 0.9%, respectively. The incidences of postextraction bleeding per procedure for DOACs, VKAs and no anticoagulants were 9.7%, 10.0% and 1.1%, respectively. In comparison to the VKA extractions, the DOAC extractions did not significantly increase the risk of postextraction bleeding (OR 0.69, 95% CIs 0.24 to 1.97; p=0.49). CONCLUSIONS: The risk of postextraction bleeding was similar for DOAC and VKA extractions.


Assuntos
Anticoagulantes/uso terapêutico , Hemorragia Pós-Operatória/epidemiologia , Extração Dentária/efeitos adversos , Tromboembolia Venosa/tratamento farmacológico , Vitamina K/antagonistas & inibidores , Varfarina/uso terapêutico , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/efeitos adversos , Feminino , Hospitais Universitários , Humanos , Japão , Modelos Logísticos , Masculino , Análise Multivariada , Pontuação de Propensão , Curva ROC , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Varfarina/efeitos adversos
17.
Oral Oncol ; 68: 36-43, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28438290

RESUMO

OBJECTIVES: Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transformation of oral precancerous lesions. MATERIALS AND METHODS: Patients with oral precancerous lesions managed at the Nara Medical University Hospital, Japan, (n=120) were enrolled in this study. Epithelial dysplasias were graded by experienced pathologists, and subepithelial PD-L1-, CD163-, and CD8-positive cells were counted in the superficial lamina propria of oral mucosa. Epithelial PD-L1 expression was evaluated according to the staining intensity. The association of clinicopathological factors with epithelial dysplasia, malignant-free survival time, and significance of risk factors for malignant transformation were determined. RESULTS: Multivariate analysis showed that the subepithelial CD163-positive cell count was the only significant risk factor for high-grade epithelial dysplasia (P<0.001), while subepithelial CD163- and PD-L1-positive cell counts, and epithelial PD-L1 positivity were significantly associated with malignant-free survival (P=0.004, 0.04, and <0.001, respectively). Subepithelial PD-L1-positive cell count and epithelial PD-L1 positivity were significantly associated with malignant transformation (P=0.01 and 0.04, respectively). CONCLUSION: Our results indicate that PD-L1-expressing dysplastic epithelial and recruited subepithelial cells in oral precancerous legions may evade the host immune system, and that the inhibition of PD-1/PD-L1 pathway may potentially prevent malignant transformation of oral precancerous legions as well as can treat advanced cancers.


Assuntos
Antígeno B7-H1/metabolismo , Neoplasias Bucais/metabolismo , Lesões Pré-Cancerosas/metabolismo , Microambiente Tumoral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Antígenos CD/imunologia , Criança , Feminino , Humanos , Imunofenotipagem , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/imunologia , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/imunologia , Lesões Pré-Cancerosas/patologia , Estudos Retrospectivos , Análise de Sobrevida , Adulto Jovem
18.
Open Dent J ; 10: 261-7, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27386012

RESUMO

We report a case of chronic maxillary sinusitis caused by denture lining material entering through an oroantral fistula after tooth extraction. The patient was an 80-year-old female who visited us with a complaint of pus discharge from the right posterior maxilla. She had extraction of the upper right second molar and had her upper denture relined with silicone lining material. The patient noticed swelling of the right cheek and purulent rhinorrhea 20 days before her first visit to our clinic. Oral examination showed an oroantral fistula with a diameter of 3 mm in the posterior alveolar ridge of the right maxilla. Computed tomography revealed a hyperdense foreign body in the right maxillary sinus and thickening of the mucosal lining. Under diagnosis of maxillary sinusitis caused by a foreign body, endoscopic maxillary surgery was performed simultaneously with the removal of the foreign body. The foreign body removed was 12 × 6 mm in size, oval in shape, light pink in color, and compatible with silicone denture lining material. During the follow-up it was observed that the oroantral fistula closed spontaneously after the removal of the foreign body. The maxillary sinus was in a good shape without recurrence of sinusitis seven months after surgery.

19.
Craniomaxillofac Trauma Reconstr ; 8(4): 281-8, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26576232

RESUMO

Trend and characteristics of maxillofacial fractures in 2,636 patients over 32 years were analyzed retrospectively. Patients comprised 1,764 males and 872 females with ages ranging from 0 to 99 years. Patients younger than 30 years consisted of 60% maxillofacial fractures in the early period but decreased to 40% in the late period. In contrast, patients older than 60 years gradually increased to 30%. In terms of cause, traffic accidents consisted of more than 50%, predominantly motorcycle accidents, but gradually decreased to 40%. In contrast, falls markedly increased from less than 10 to 30%. Fractures occurred in the midface in 938 patients, in the mandible in 1,490, and in both in 208. In the midface, zygoma fractures consisted of 50% throughout the period. In the mandible, condyle fractures were observed in 40%, followed by fractures of the symphysis and angle. The ratio of condylar fractures slightly increased. Open reduction and internal fixation (ORIF) were performed in 782 patients, followed by observation in 716, maxillomandibular fixation (MMF) in 605, intramaxillary splinting (IMS) in 294, transcutaneous reduction (TCR) in 126, and others in 113. MMF markedly decreased from more than 30 to less than 5% and observation increased from 20 to 40%.

20.
Ann Maxillofac Surg ; 5(1): 77-81, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26389039

RESUMO

PURPOSE: The purpose was to analyze the clinical course of surgically treated mandibular angle fractures from the viewpoint of routine removal of the plate because these fractures are associated with high rates of complications and plate removal. SUBJECTS AND METHODS: The subjects were 40 patients with unilateral mandibular angle fracture, which was intraorally reduced and principally fixed with a single miniplate on the external oblique ridge. The third molar in relation to the fracture line was extracted in seven patients during the surgery. Clinical course was evaluated in terms of removal of the plate, preservation of the third molar and complications. RESULTS: One patient showed a wound infection postoperatively, and two patients developed pericoronitis during the follow-up. These were managed with medication and local irrigation. One patient with a preserved third molar did not make a required visit and was lost from the follow-up. Removal of the plates was performed in 39 patients after confirmation of good fracture healing, mostly within a year. Twenty-four of 32 preserved third molars were simultaneously extracted. These procedures were generally performed under local anesthesia on an outpatient basis, and they did not cause any complications. CONCLUSIONS: Routine removal of the plate after surgical treatment for mandibular angle fractures, simultaneously with extraction of the third molar if indicated, may be beneficial to avoid complications related to the plate and the third molar later in life.

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