Detalhe da pesquisa
1.
A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans.
Hepatology
; 78(3): 709-726, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999529
2.
Impact of elobixibat on serum and fecal bile acid levels and constipation symptoms in patients with chronic constipation.
J Gastroenterol Hepatol
; 37(5): 883-890, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35168298
3.
Systematic Review and Meta-analysis: Partial External Biliary Diversion in Progressive Familial Intrahepatic Cholestasis.
J Pediatr Gastroenterol Nutr
; 71(2): 176-183, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32433433
4.
Efficacy and safety of odevixibat in patients with Alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial.
Lancet Gastroenterol Hepatol
; 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670135
5.
Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis.
JHEP Rep
; 5(8): 100782, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37456676
6.
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Lancet Gastroenterol Hepatol
; 7(9): 830-842, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35780807
7.
Effects of odevixibat on pruritus and bile acids in children with cholestatic liver disease: Phase 2 study.
Clin Res Hepatol Gastroenterol
; 45(5): 101751, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34182185
8.
(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
J Pharmacol Exp Ther
; 331(2): 504-12, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19648470
9.
Efficacy, long-term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan.
Neurogastroenterol Motil
; 31(5): e13571, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30793431
10.
Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial.
Lancet Gastroenterol Hepatol
; 3(8): 537-547, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29805116
11.
Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.
J Comp Neurol
; 503(1): 35-46, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17480026
12.
Effects of (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice.
Br J Pharmacol
; 146(1): 89-97, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15980875
13.
Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist.
Eur J Pharmacol
; 519(1-2): 154-7, 2005 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16102747
14.
Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice.
Br J Pharmacol
; 140(2): 315-22, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12970075
15.
Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.
Gene Expr Patterns
; 10(1): 65-74, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19850157
16.
Differential regulation of TRP channels in a rat model of neuropathic pain.
Pain
; 144(1-2): 187-99, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19446956
17.
Down regulation of TRPC1 by shRNA reduces mechanosensitivity in mouse dorsal root ganglion neurons in vitro.
Neurosci Lett
; 457(1): 3-7, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19429150
18.
Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.
J Med Chem
; 51(14): 4315-20, 2008 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18578471
19.
Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues.
Bioorg Med Chem Lett
; 16(5): 1142-5, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16380255
20.
Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
Bioorg Med Chem Lett
; 16(9): 2467-9, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16481165