Detalhe da pesquisa
1.
Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity.
Cell
; 168(5): 867-877.e13, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235198
2.
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia.
Nature
; 597(7877): 571-576, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34497422
3.
Structure of the adenosine-bound human adenosine A1 receptor-Gi complex.
Nature
; 558(7711): 559-563, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29925945
4.
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery.
Clin Sci (Lond)
; 136(23): 1731-1758, 2022 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459456
5.
Adenosine receptor signalling in Alzheimer's disease.
Purinergic Signal
; 18(3): 359-381, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35870032
6.
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 115(10): E2419-E2428, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453275
7.
A kinetic view of GPCR allostery and biased agonism.
Nat Chem Biol
; 13(9): 929-937, 2017 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28820879
8.
"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
Mol Pharmacol
; 93(5): 504-514, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29514854
9.
Biased agonism and allosteric modulation of metabotropic glutamate receptor 5.
Clin Sci (Lond)
; 132(21): 2323-2338, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389826
10.
Publisher Correction to: Adenosine receptor signalling in Alzheimer's disease.
Purinergic Signal
; 18(4): 407, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36383276
11.
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist.
Proc Natl Acad Sci U S A
; 111(12): 4614-9, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24619092
12.
Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.
Mol Pharmacol
; 90(1): 12-22, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27136943
13.
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.
Mol Pharmacol
; 90(6): 715-725, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27683013
14.
Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.
Mol Pharmacol
; 90(6): 703-714, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27683014
15.
Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation.
J Pharmacol Exp Ther
; 357(1): 36-44, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26791603
16.
Negative cooperativity across ß1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 ß1-adrenoceptor binding conformation.
FASEB J
; 29(7): 2859-71, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25837585
17.
VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model.
Clin Exp Pharmacol Physiol
; 43(10): 976-82, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377874
18.
A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model.
Mol Pharmacol
; 88(3): 460-8, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26104547
19.
The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.
Curr Opin Struct Biol
; 79: 102560, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848776
20.
Small molecule allosteric modulation of the adenosine A1 receptor.
Front Endocrinol (Lausanne)
; 14: 1184360, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37435481