Detalhe da pesquisa
1.
Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.
PLoS Biol
; 18(12): e3001008, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33315860
2.
Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration.
Brain
; 145(12): 4287-4307, 2022 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35776111
3.
Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter.
Acta Neuropathol
; 141(4): 585-604, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33569629
4.
Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration.
Acta Neuropathol
; 141(6): 881-899, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33779783
5.
Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder.
Brain
; 143(3): 811-832, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32125365
6.
PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-ß generation by reducing ß-secretase in an Alzheimer's disease model.
Proc Natl Acad Sci U S A
; 113(43): 12292-12297, 2016 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27791018
7.
IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention.
EMBO J
; 33(23): 2814-28, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361605
8.
Rabies virus envelope glycoprotein targets lentiviral vectors to the axonal retrograde pathway in motor neurons.
J Biol Chem
; 289(23): 16148-63, 2014 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24753246
9.
Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
Lancet
; 383(9923): 1138-46, 2014 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412048
10.
Enhanced central nervous system transduction with lentiviral vectors pseudotyped with RVG/HIV-1gp41 chimeric envelope glycoproteins.
J Virol
; 88(5): 2877-90, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24371049
11.
Dose-dependent neuroprotection of VEGF165 in Huntington's disease striatum.
Mol Ther
; 21(10): 1862-75, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23799534
12.
Anticancer gene transfer for cancer gene therapy.
Adv Exp Med Biol
; 818: 255-80, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25001541
13.
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
Proc Natl Acad Sci U S A
; 107(16): 7556-61, 2010 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20368421
14.
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.
Nat Med
; 11(4): 429-33, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15768029
15.
Not Just Loss-of-Function Variations: Identification of a Hypermorphic Variant in a Patient With a CDKL5 Missense Substitution.
Neurol Genet
; 8(2): e666, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35280940
16.
Viral Vector Delivery of DREADDs for CNS Therapy.
Curr Gene Ther
; 21(3): 191-206, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573551
17.
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.
Nature
; 429(6990): 413-7, 2004 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15164063
18.
Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cord.
Nat Neurosci
; 9(2): 243-50, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16388307
19.
Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration.
Acta Neuropathol Commun
; 8(1): 66, 2020 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32398070
20.
Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models.
Sci Transl Med
; 12(551)2020 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32641489