Detalhe da pesquisa
1.
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.
Cell
; 146(1): 37-52, 2011 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21700325
2.
Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition.
J Neurosci
; 43(14): 2615-2629, 2023 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788031
3.
Acetylation targets mutant huntingtin to autophagosomes for degradation.
Cell
; 137(1): 60-72, 2009 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19345187
4.
Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo.
Proc Natl Acad Sci U S A
; 118(50)2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893541
5.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease.
N Engl J Med
; 381(17): 1644-1652, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31597037
6.
Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity.
J Neurosci
; 39(29): 5760-5772, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31097622
7.
Modeling neuronopathic storage diseases with patient-derived culture systems.
Neurobiol Dis
; 127: 147-162, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30790616
8.
Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease.
Neurobiol Dis
; 122: 72-82, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29550539
9.
Is Parkinson's disease a lysosomal disorder?
Brain
; 141(8): 2255-2262, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29860491
10.
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.
Proc Natl Acad Sci U S A
; 113(7): 1931-6, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26839413
11.
Characterization of the complex formed by ß-glucocerebrosidase and the lysosomal integral membrane protein type-2.
Proc Natl Acad Sci U S A
; 113(14): 3791-6, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27001828
12.
Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.
Cell Tissue Res
; 373(1): 51-60, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29064079
13.
Activation of ß-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
J Neurosci
; 36(29): 7693-706, 2016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27445146
14.
LIMP-2 expression is critical for ß-glucocerebrosidase activity and α-synuclein clearance.
Proc Natl Acad Sci U S A
; 111(43): 15573-8, 2014 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25316793
15.
Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence.
Anal Chem
; 88(4): 2399-405, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26813311
16.
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.
Hum Mol Genet
; 22(10): 2067-82, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23393156
17.
α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson's disease.
Neuroscientist
; : 10738584241232963, 2024 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38420922
18.
Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson's disease and dementia with Lewy bodies.
Neuron
; 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38761794
19.
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging.
Nat Commun
; 15(1): 264, 2024 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38238311
20.
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.
J Neurosci
; 32(12): 4240-6, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22442086