Detalhe da pesquisa
1.
Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites.
Genome Res
; 34(3): 441-453, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38604731
2.
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei.
Proc Natl Acad Sci U S A
; 120(48): e2309306120, 2023 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37988471
3.
Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation.
Nucleic Acids Res
; 51(20): 11123-11141, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37843098
4.
Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication.
Trends Genet
; 37(1): 21-34, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32993968
5.
AAK1-like: A putative pseudokinase with potential roles in cargo uptake in bloodstream form Trypanosoma brucei parasites.
J Eukaryot Microbiol
; 70(6): e12994, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37548427
6.
The dynamic subcellular localisation of Rad1 is cell cycle dependent in Leishmania major.
Exp Parasitol
; 255: 108639, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37918502
7.
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes.
Nucleic Acids Res
; 49(3): 1436-1454, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450001
8.
Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication.
PLoS Genet
; 16(7): e1008828, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32609721
9.
Genome maintenance functions of a putative Trypanosoma brucei translesion DNA polymerase include telomere association and a role in antigenic variation.
Nucleic Acids Res
; 48(17): 9660-9680, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890403
10.
Application of single-cell transcriptomics to kinetoplastid research.
Parasitology
; 148(10): 1223-1236, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33678213
11.
Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation.
Nucleic Acids Res
; 47(17): 9180-9197, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31350892
12.
Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion.
PLoS Genet
; 14(12): e1007729, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30543624
13.
Replication origin location might contribute to genetic variability in Trypanosoma cruzi.
BMC Genomics
; 21(1): 414, 2020 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32571205
14.
Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.
PLoS Pathog
; 14(11): e1007321, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30440029
15.
Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome.
Nucleic Acids Res
; 46(22): 11789-11805, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30304482
16.
Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania.
Nucleic Acids Res
; 46(22): 11835-11846, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30380080
17.
Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.
PLoS Pathog
; 13(7): e1006477, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28742144
18.
Conservation and Variation in Strategies for DNA Replication of Kinetoplastid Nuclear Genomes.
Curr Genomics
; 19(2): 98-109, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29491738
19.
Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation.
Nucleic Acids Res
; 44(10): 4763-84, 2016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951375
20.
Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania.
Mol Microbiol
; 101(6): 1054-68, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27301589