Detalhe da pesquisa
1.
Modifying the Basicity of the dNTP Leaving Group Modulates Precatalytic Conformational Changes of DNA Polymerase ß.
Biochemistry
; 63(11): 1412-1422, 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38780930
2.
Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies.
J Am Chem Soc
; 146(5): 3220-3229, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38271668
3.
Paradoxical androgen receptor regulation by small molecule enantiomers.
Proc Natl Acad Sci U S A
; 118(12)2021 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33741738
4.
Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration.
Bioorg Med Chem
; 92: 117425, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37544256
5.
Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates.
Int J Mol Sci
; 24(3)2023 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36768310
6.
Microwave-Accelerated McKenna Synthesis of Phosphonic Acids: An Investigation.
Molecules
; 28(8)2023 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37110732
7.
Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding.
J Comput Chem
; 43(32): 2121-2130, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36190786
8.
Kinetic Effects of ß,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA.
Biochemistry
; 60(1): 1-5, 2021 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356161
9.
Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model.
Bioconjug Chem
; 32(5): 916-927, 2021 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33956423
10.
Synthesis of 8-oxo-dGTP and its ß,γ-CH2-, ß, γ-CHF-, and ß, γ-CF2- analogues.
Tetrahedron Lett
; 672021 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33716328
11.
A pre-catalytic non-covalent step governs DNA polymerase ß fidelity.
Nucleic Acids Res
; 47(22): 11839-11849, 2019 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31732732
12.
Revealing an Internal Stabilization Deficiency in the DNA Polymerase ß K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry
; 59(8): 955-963, 2020 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31999437
13.
Completing the ß,γ-CXY-dNTP Stereochemical Probe Toolkit: Synthetic Access to the dCTP Diastereomers and 31P and 19F NMR Correlations with Absolute Configurations.
J Org Chem
; 85(22): 14592-14609, 2020 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33125847
14.
A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and ß.
Biochemistry
; 58(13): 1764-1773, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30839203
15.
Diketopyrrolopyrrole Bis-Phosphonate Conjugate: A New Fluorescent Probe for In Vitro Bone Imaging.
Chemistry
; 25(14): 3617-3626, 2019 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30600841
16.
Mapping Functional Substrate-Enzyme Interactions in the pol ß Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry
; 57(26): 3934-3944, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29874056
17.
Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.
Biochemistry
; 57(26): 3925-3933, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889506
18.
Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss.
Bioconjug Chem
; 29(4): 1240-1250, 2018 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485861
19.
Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution.
Nucleic Acids Res
; 44(8): 3820-8, 2016 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27060150
20.
DNA Polymerase ß Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the ß-γ Bridging Group of the Incoming dNTP.
Biochemistry
; 56(40): 5449-5456, 2017 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28862868