Detalhe da pesquisa
1.
Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry
; 62(14): 2182-2201, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37418678
2.
Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases.
Biochemistry
; 61(19): 2088-2105, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36193631
3.
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.
Bioorg Med Chem
; 74: 117038, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36209571
4.
Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid.
J Am Chem Soc
; 143(42): 17666-17676, 2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34664502
5.
Inhibiting Sialidase-Induced TGF-ß1 Activation Attenuates Pulmonary Fibrosis in Mice.
J Pharmacol Exp Ther
; 376(1): 106-117, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33144389
6.
Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 114(29): 7617-7622, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679637
7.
Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36.
Proc Natl Acad Sci U S A
; 113(5): 1197-201, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787850
8.
Catalytic Mechanism of Cruzain from Trypanosoma cruzi As Determined from Solvent Kinetic Isotope Effects of Steady-State and Pre-Steady-State Kinetics.
Biochemistry
; 57(22): 3176-3190, 2018 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29336553
9.
Enhanced Antibiotic Discovery by PROSPECTing.
Biochemistry
; 58(33): 3475-3476, 2019 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31397555
10.
On the catalytic mechanism of human ATP citrate lyase.
Biochemistry
; 51(25): 5198-211, 2012 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22657152
11.
The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.
Biochemistry
; 51(38): 7551-68, 2012 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22928782
12.
Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active.
PLoS Negl Trop Dis
; 16(2): e0009926, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104286
13.
Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents.
Front Chem
; 10: 867928, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35860632
14.
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
J Med Chem
; 65(4): 2956-2970, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34730959
15.
Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
Biochemistry
; 50(31): 6642-54, 2011 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21711014
16.
Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid.
ACS Chem Biol
; 16(3): 463-470, 2021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33688722
17.
Dinitrosyl iron complexes (DNICs) as inhibitors of the SARS-CoV-2 main protease.
Chem Commun (Camb)
; 57(67): 8352-8355, 2021 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34337637
18.
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
ACS Chem Biol
; 16(4): 642-650, 2021 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33787221
19.
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
J Med Chem
; 64(15): 11267-11287, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34288674
20.
Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.
Biochemistry
; 49(33): 7151-63, 2010 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20597513