Detalhe da pesquisa
1.
In vivo maintenance of human regulatory T cells during CD25 blockade.
J Immunol
; 194(1): 84-92, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25416807
2.
Population PK-PD analyses of CD25 occupancy, CD56bright NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis.
Br J Clin Pharmacol
; 82(5): 1333-1342, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27333593
3.
Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN.
J Immunol
; 183(10): 6545-53, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19864603
4.
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Clin Transl Immunology
; 10(6): e1295, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141433
5.
Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice.
Immunology
; 130(1): 103-13, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20059577
6.
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
J Med Chem
; 63(21): 12526-12541, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696648
7.
Well-developed ligand-binding assays demonstrate robust performance using singlet analysis.
Bioanalysis
; 11(22): 2075-2086, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31829740
8.
Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice.
Neurology
; 92(15): e1724-e1738, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30918100
9.
2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62).
Bioanalysis
; 11(24): 2207-2244, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820675
10.
Immune response to vaccines is maintained in patients treated with dimethyl fumarate.
Neurol Neuroimmunol Neuroinflamm
; 5(1): e409, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29159204
11.
2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays).
Bioanalysis
; 10(24): 1973-2001, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30488726
12.
2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays).
Bioanalysis
; 9(24): 1967-1996, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29205064
13.
Parallelism: the foundation of biomarker assay development and validation.
Bioanalysis
; 10(12): 897-899, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29923751
14.
Novel data analysis methods to overcome cut point challenges and enable comprehensive assessment of antidrug binding activity in confirmatory assays.
J Immunol Methods
; 392(1-2): 38-48, 2013 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541489
15.
The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts.
PLoS One
; 7(2): e31688, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22363706
16.
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.
Proc Natl Acad Sci U S A
; 102(6): 2016-21, 2005 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15684054
17.
Biology of IL-21 and the IL-21 receptor.
Immunol Rev
; 202: 84-95, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546387
18.
IL-21 induces the apoptosis of resting and activated primary B cells.
J Immunol
; 170(8): 4111-8, 2003 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12682241