Detalhe da pesquisa
1.
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Proc Natl Acad Sci U S A
; 119(15): e2109617119, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35353605
2.
The promise of the TGF-ß superfamily as a therapeutic target for Parkinson's disease.
Neurobiol Dis
; 171: 105805, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764291
3.
Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.
Mov Disord
; 35(11): 2095-2100, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32652692
4.
Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
Biochem J
; 476(3): 559-579, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670570
5.
Endogenous Alpha-Synuclein is Essential for the Transfer of Pathology by Exosome-Enriched Extracellular Vesicles, Following Inoculation with Preformed Fibrils in vivo.
Aging Dis
; 15(2): 869-892, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37548944
6.
Assessment of Aggregated and Exosome-Associated α-Synuclein in Brain Tissue and Cerebrospinal Fluid Using Specific Immunoassays.
Diagnostics (Basel)
; 13(13)2023 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37443586
7.
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.
J Neurosci
; 30(20): 6838-51, 2010 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484626
8.
Intrastriatal Administration of Exosome-Associated Pathological Alpha-Synuclein Is Not Sufficient by Itself to Cause Pathology Transmission.
Front Neurosci
; 14: 246, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32372894
9.
A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.
Sci Rep
; 8(1): 3455, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29472595
10.
Clinical characterization of a novel calcium sensing receptor genetic alteration in a Greek patient with autosomal dominant hypocalcemia type 1.
Hormones (Athens)
; 16(2): 200-204, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28742508
11.
Identification and Functional Characterization of a Calcium-Sensing Receptor Mutation in an Infant with Familial Hypocalciuric Hypercalcemia.
J Clin Res Pediatr Endocrinol
; 8(3): 341-6, 2016 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27087013
12.
Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.
PLoS One
; 11(11): e0166053, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27832104
13.
Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.
Neurobiol Aging
; 34(12): 2853-65, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23891486