RESUMO
This article describes a new synthetic method for obtaining three water soluble porphyrins. The more sophisticated porphyrin [5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide], also named C12 porphyrin, was obtained through a three step methodology. The improvements, compared to syntheses described in the literature, mostly concern the purification procedures. The photophysical properties of the three porphyrins are described and the C12 porphyrin presents a very good (1)O2 yield compared to its chemical intermediates. This porphyrin seems to be a very promising candidate for PDT applications.
Assuntos
Culicidae/efeitos dos fármacos , Culicidae/efeitos da radiação , Malária/prevenção & controle , Porfirinas/síntese química , Porfirinas/farmacologia , Compostos de Piridínio/síntese química , Compostos de Piridínio/farmacologia , Animais , Antimaláricos/síntese química , Antimaláricos/farmacologia , Larva/efeitos dos fármacos , Larva/efeitos da radiação , Estrutura Molecular , Controle de Mosquitos/métodos , Luz SolarRESUMO
A high-yielding sequence of [2+2] cycloaddition-retroelectrocyclization of ynamides with tetracyanoethylene (TCNE) is described. The reaction provided tetracyanobutadiene (TCBD) species, which were characterized by various techniques. DFT and TD-DFT calculations were also performed to complement experimental findings.