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1.
Vestn Ross Akad Med Nauk ; (9): 20-7, 2009.
Artigo em Russo | MEDLINE | ID: mdl-19830918

RESUMO

The paper reports a review and analysis of the literature on preparation of hemopoietic stem cells (HSC) for allogeneic and autologic transplantation to adult patients with malignant neoplasms. Original data on the collection of HSC from different sources are presented along with prognostic factors for preparing sufficient amounts of HSC. The cells were obtained from a total of 122 subjects (298 procedures). It is shown that the choice of a HSC source and mobilization procedure on an individual basis ensures relatively safe HSC transplantation to all the patients for whom this operation is the treatment of choice.


Assuntos
Transplante de Células-Tronco Hematopoéticas/métodos , Neoplasias/cirurgia , Coleta de Tecidos e Órgãos/métodos , Adulto , Humanos
2.
Gematol Transfuziol ; 41(1): 6-9, 1996.
Artigo em Russo | MEDLINE | ID: mdl-8641585

RESUMO

The success in acute myeloblastic leukemia (AML) treatment for the last 10 years has been referred to growing intensity of chemotherapy. The efficacy of treatment has been assessed in 56 patients under 60 years of age. Double induction of remission according to the scheme TAD-9 (2-day administration of cytosar) and consolidation by large-dose cytosar (1 g/m2) with rubomycin have increased the frequency of 2-year recurrence-free running from 13 to 35%. Resistance to treatment was absent. Maintenance prolonged total and recurrence-free survival. Mycosis and hepatitis were factors responsible for inadequate intensity of chemotherapy. These need more advanced prevention. The intensive double induction and consolidation did not raise general toxicity and immediate lethality compared to standard regimens which proved inferior to the proposed treatment.


Assuntos
Antineoplásicos/uso terapêutico , Leucemia Mieloide Aguda/tratamento farmacológico , Adulto , Feminino , Humanos , Masculino , Indução de Remissão/métodos
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