Detalhe da pesquisa
1.
Difelikefalin in Black/African American Hemodialysis Patients with Moderate-to-Severe Pruritus: Post-hoc Analysis of KALM-1 and KALM-2.
Am J Nephrol
; 2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38253036
2.
A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus.
N Engl J Med
; 382(3): 222-232, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31702883
3.
Difelikefalin improves itch-related sleep disruption in patients undergoing haemodialysis.
Nephrol Dial Transplant
; 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37968132
4.
A phase 2 study of oral difelikefalin in subjects with chronic kidney disease and moderate-to-severe pruritus.
J Am Acad Dermatol
; 89(2): 261-268, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37059302
5.
Clinically meaningful change in itch intensity scores: An evaluation in patients with chronic kidney disease-associated pruritus.
J Am Acad Dermatol
; 84(4): 1132-1134, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32603719
6.
CKD-Associated Pruritus and Clinical Outcomes in Nondialysis CKD.
Kidney Med
; 6(1): 100754, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38225976
7.
Assessment of the physical dependence potential of difelikefalin: Randomized placebo-controlled study in patients receiving hemodialysis.
Clin Transl Sci
; 16(9): 1559-1568, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37128642
8.
The Burden of Pruritus Associated With CKD: A Mixed Methods Analysis Among Patients Undergoing Dialysis.
Kidney Med
; 5(9): 100696, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37637864
9.
Pharmacokinetics, Metabolism, and Excretion of Intravenous [14C]Difelikefalin in Healthy Subjects and Subjects on Hemodialysis.
Clin Pharmacokinet
; 62(9): 1231-1241, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37369955
10.
Safety and Tolerability of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis From the Phase 3 Clinical Trial Program.
Kidney Med
; 4(8): 100513, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36039153
11.
Evaluation of the abuse potential of difelikefalin, a selective kappa-opioid receptor agonist, in recreational polydrug users.
Clin Transl Sci
; 15(2): 535-547, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34708917
12.
Safety and Effectiveness of Difelikefalin in Patients With Moderate-to-Severe Pruritus Undergoing Hemodialysis: An Open-Label, Multicenter Study.
Kidney Med
; 4(10): 100542, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36185706
13.
Efficacy of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis of KALM-1 and KALM-2 Phase 3 Studies.
Kidney Med
; 4(8): 100512, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36016762
14.
Utility of a Single Itch-Related Question and the Skindex-10 Questionnaire for Assessing Pruritus and Predicting Health-Related Quality of Life in Patients Receiving Hemodialysis.
Kidney Med
; 4(6): 100476, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35651592
15.
Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus.
J Patient Rep Outcomes
; 5(1): 134, 2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34952964
16.
Self-reported Pruritus and Clinical, Dialysis-Related, and Patient-Reported Outcomes in Hemodialysis Patients.
Kidney Med
; 3(1): 42-53.e1, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33604539
17.
Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients.
Kidney Int Rep
; 5(5): 600-610, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32405581
18.
Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain.
Anesthesiology
; 111(3): 616-24, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19672186
19.
Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.
J Pharmacol Exp Ther
; 325(2): 577-87, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18252809
20.
Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
J Med Chem
; 51(2): 305-13, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18095642